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While a multi-agent approach based on large language models (LLMs) represents a promising strategy to surpass the capabilities of single models, its success is critically dependent on synergistic team composition. However, forming optimal…

Computation and Language · Computer Science 2026-03-20 Kotaro Furuya , Yuichi Kitagawa

The performance of finetuned large language models (LLMs) hinges critically on the composition of the training mixture. However, selecting an optimal blend of task datasets remains a largely manual, heuristic driven process, with…

In recent years, Large Language Models (LLMs) have achieved significant success in natural language processing (NLP) and various interdisciplinary areas. However, applying LLMs to chemistry is a complex task that requires specialized domain…

Machine Learning · Computer Science 2024-02-05 Chang Liao , Yemin Yu , Yu Mei , Ying Wei

This work presents an analytical framework for the design and analysis of LLM-based algorithms, i.e., algorithms that contain one or multiple calls of large language models (LLMs) as sub-routines and critically rely on the capabilities of…

Machine Learning · Computer Science 2025-10-14 Yanxi Chen , Yaliang Li , Bolin Ding , Jingren Zhou

Building effective clinical decision support systems requires the synthesis of complex heterogeneous multimodal data. Such modalities include temporal electronic health records data, medical images, radiology reports, and clinical notes.…

Artificial Intelligence · Computer Science 2026-05-12 Baraa Al Jorf , Farah E. Shamout

Large language models (LLMs) are beginning to reshape how chemists plan and run reactions in organic synthesis. Trained on millions of reported transformations, these text-based models can propose synthetic routes, forecast reaction…

Artificial Intelligence · Computer Science 2025-08-08 Kartar Kumar Lohana Tharwani , Rajesh Kumar , Sumita , Numan Ahmed , Yong Tang

LLM Ensemble -- which involves the comprehensive use of multiple large language models (LLMs), each aimed at handling user queries during downstream inference, to benefit from their individual strengths -- has gained substantial attention…

Uncertainty estimation is a significant issue for current large language models (LLMs) that are generally poorly calibrated and over-confident, especially with reinforcement learning from human feedback (RLHF). Unlike humans, whose…

Computation and Language · Computer Science 2024-05-13 Ruixin Yang , Dheeraj Rajagopal , Shirley Anugrah Hayati , Bin Hu , Dongyeop Kang

While automated chemical tools excel at specific tasks, they have struggled to capture the strategic thinking that characterizes expert chemical reasoning. Here we demonstrate that large language models (LLMs) can serve as powerful tools…

Artificial Intelligence · Computer Science 2025-07-25 Andres M Bran , Theo A Neukomm , Daniel P Armstrong , Zlatko Jončev , Philippe Schwaller

Large language models (LLMs) are often ensembled together to improve overall reliability and robustness, but in practice models are strongly correlated. This raises a fundamental question: which models should be selected when forming an LLM…

Machine Learning · Computer Science 2026-02-10 Yigit Turkmen , Baturalp Buyukates , Melih Bastopcu

The analysis and mining of user heterogeneous behavior are of paramount importance in recommendation systems. However, the conventional approach of incorporating various types of heterogeneous behavior into recommendation models leads to…

Information Retrieval · Computer Science 2023-08-21 Bin Yin , Junjie Xie , Yu Qin , Zixiang Ding , Zhichao Feng , Xiang Li , Wei Lin

As Natural Language Processing (NLP) systems are increasingly employed in intricate social environments, a pressing query emerges: Can these NLP systems mirror human-esque collaborative intelligence, in a multi-agent society consisting of…

Computation and Language · Computer Science 2024-05-28 Jintian Zhang , Xin Xu , Ningyu Zhang , Ruibo Liu , Bryan Hooi , Shumin Deng

Large Language Models (LLMs) are increasingly being integrated into software development processes, with the potential to transform team workflows and productivity. This paper investigates how LLMs affect team collaboration throughout the…

Software Engineering · Computer Science 2025-10-13 Devang Dhanuka

Identifying reaction conditions that are broadly applicable across diverse substrates is a longstanding challenge in chemical and pharmaceutical research. While many methods are available to generate conditions with acceptable performance,…

Artificial Intelligence · Computer Science 2025-09-26 Yu Zhang , Ruijie Yu , Kaipeng Zeng , Ding Li , Feng Zhu , Xiaokang Yang , Yaohui Jin , Yanyan Xu

MixRx uses Large Language Models (LLMs) to classify drug combination interactions as Additive, Synergistic, or Antagonistic, given a multi-drug patient history. We evaluate the performance of 4 models, GPT-2, Mistral Instruct 2.0, and the…

Other Quantitative Biology · Quantitative Biology 2026-01-08 Risha Surana , Cameron Saidock , Hugo Chacon

Recent progress in large language models (LLMs) has focused on producing responses that meet human expectations and align with shared values - a process coined alignment. However, aligning LLMs remains challenging due to the inherent…

The growing diversity of large language models (LLMs) means users often need to compare and combine outputs from different models to obtain higher-quality or more comprehensive responses. However, switching between separate interfaces and…

Human-Computer Interaction · Computer Science 2025-10-23 Yingtian Shi , Jinda Yang , Yuhan Wang , Yiwen Yin , Haoyu Li , Kunyu Gao , Chun Yu

Large language models (LLMs) offer strong capabilities but raise cost and privacy concerns, whereas small language models (SLMs) facilitate efficient and private local inference yet suffer from limited capacity. To synergize the…

Computation and Language · Computer Science 2026-04-21 Hang Zeng , Xiangyu Liu , Yong Hu , Chaoyue Niu , Jiarui Zhang , Shaojie Tang , Fan Wu , Guihai Chen

Large Language Models (LLMs) have drawn widespread attention and research due to their astounding performance in text generation and reasoning tasks. Derivative products, like ChatGPT, have been extensively deployed and highly sought after.…

Software Engineering · Computer Science 2024-12-11 Zibin Zheng , Kaiwen Ning , Qingyuan Zhong , Jiachi Chen , Wenqing Chen , Lianghong Guo , Weicheng Wang , Yanlin Wang

Large language models (LLMs) can support scientific literature synthesis, but remain prone to hallucinated references, uneven coverage, and weakly grounded thematic organization. We evaluate whether bibliometric structure improves…

Computation and Language · Computer Science 2026-05-26 Abraham Camelo-Guerrero , Jairo Diaz-Rodriguez