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Whole-slide image (WSI) classification in computational pathology is commonly formulated as slide-level Multiple Instance Learning (MIL) with a single global bag representation. However, slide-level MIL is fundamentally underconstrained:…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Syed Fahim Ahmed , Gnanesh Rasineni , Florian Koehler , Abu Zahid Bin Aziz , Mei Wang , Attila Gyulassy , Brian Summa , J. Quincy Brown , Valerio Pascucci , Shireen Y. Elhabian

Processing giga-pixel whole slide histopathology images (WSI) is a computationally expensive task. Multiple instance learning (MIL) has become the conventional approach to process WSIs, in which these images are split into smaller patches…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Ramin Nakhli , Puria Azadi Moghadam , Haoyang Mi , Hossein Farahani , Alexander Baras , Blake Gilks , Ali Bashashati

Gastric cancer is one of the most commonly diagnosed cancers and has a high mortality rate. Due to limited medical resources, developing machine learning models for gastric cancer recognition provides an efficient solution for medical…

Machine Learning · Computer Science 2025-03-21 Yuxin Miao , Xinyuan Yang , Hongda Fan , Yichun Li , Yishu Hong , Xiechen Guo , Ali Braytee , Weidong Huang , Ali Anaissi

Multiple organ failure (MOF) is a life-threatening condition. Due to its urgency and high mortality rate, early detection is critical for clinicians to provide appropriate treatment. In this paper, we perform quantitative analysis on early…

Machine Learning · Computer Science 2021-04-26 Yuqing Wang , Yun Zhao , Rachael Callcut , Linda Petzold

Moving from animal models to human applications in preclinical research encompasses a broad spectrum of disciplines in medical science. A fundamental element in the development of new drugs, treatments, diagnostic methods, and in deepening…

Image and Video Processing · Electrical Eng. & Systems 2025-02-10 Lining Yu , Mengmeng Yin , Ruining Deng , Quan Liu , Tianyuan Yao , Can Cui , Yitian Long , Yu Wang , Yaohong Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Computational pathology involves the digitization of stained tissues into whole-slide images (WSIs) that contain billions of pixels arranged as contiguous patches. Statistical analysis of WSIs largely focuses on classification via multiple…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 So Won Jeong , Veronika Ročková

Though multiple instance learning (MIL) has been a foundational strategy in computational pathology for processing whole slide images (WSIs), current approaches are designed for traditional hematoxylin and eosin (H&E) slides rather than…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Marc Harary , Eliezer M. Van Allen , William Lotter

Face Attribute Recognition (FAR) plays a crucial role in applications such as person re-identification, face retrieval, and face editing. Conventional multi-task attribute recognition methods often process the entire feature map for feature…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Gong Gao , Zekai Wang , Jian Zhao , Ziqi Xie , Xianhui Liu , Weidong Zhao

In real-world applications of human pose estimation, low-resolution input images are frequently encountered when the performance of the image acquisition equipment is limited or the shooting distance is too far. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2024-05-22 Zejun Gu , Zhong-Qiu Zhao , Hao Shen , Zhao Zhang

Histopathologists establish cancer grade by assessing histological structures, such as glands in prostate cancer. Yet, digital pathology pipelines often rely on grid-based tiling that ignores tissue architecture. This introduces irrelevant…

The burgeoning discipline of computational pathology shows promise in harnessing whole slide images (WSIs) to quantify morphological heterogeneity and develop objective prognostic modes for human cancers. However, progress is impeded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Chao Tu , Kun Huang , Jie Zhang , Qianjin Feng , Yu Zhang , Zhenyuan Ning

Pathological image analysis is an important process for detecting abnormalities such as cancer from cell images. However, since the image size is generally very large, the cost of providing detailed annotations is high, which makes it…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Akihiko Yoshizawa , Tetsuo Ushiku , Masashi Fukayama , Masanobu Kitagawa , Masaru Kitsuregawa , Tatsuya Harada

Data scarcity hinders deep learning for medical imaging. We propose a framework for breast cancer classification in thermograms that addresses this using a Diffusion Probabilistic Model (DPM) for data augmentation. Our DPM-based…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Sepehr Salem , M. Moein Esfahani , Jingyu Liu , Vince Calhoun

Multimodal federated learning enables privacy-preserving collaborative model training across healthcare institutions. However, a fundamental challenge arises from modality heterogeneity: many clinical sites possess only a subset of…

Image and Video Processing · Electrical Eng. & Systems 2026-04-15 Nafis Fuad Shahid , Maroof Ahmed , Md Akib Haider , Saidur Rahman Sagor , Aashnan Rahman , Md Azam Hossain

The potential benefits of applying machine learning methods to -omics data are becoming increasingly apparent, especially in clinical settings. However, the unique characteristics of these data are not always well suited to machine learning…

Multiple instance learning (MIL) models have achieved remarkable success in analyzing whole slide images (WSIs) for disease classification problems. However, with regard to gigapixel WSI classification problems, current MIL models are often…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Ziyu Su , Mostafa Rezapour , Usama Sajjad , Metin Nafi Gurcan , Muhammad Khalid Khan Niazi

The advancement of generative AI, particularly in medical imaging, confronts the trilemma of ensuring high fidelity, diversity, and efficiency in synthetic data generation. While Generative Adversarial Networks (GANs) have shown promise…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Lorenzo Tronchin , Tommy Löfstedt , Paolo Soda , Valerio Guarrasi

Classical multiple instance learning (MIL) methods are often based on the identical and independent distributed assumption between instances, hence neglecting the potentially rich contextual information beyond individual entities. On the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Daniel Reisenbüchler , Sophia J. Wagner , Melanie Boxberg , Tingying Peng
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