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Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

Knowledge graphs and large language models (LLMs) are key tools for biomedical knowledge integration and reasoning, facilitating structured organization of scientific articles and discovery of complex semantic relationships. However,…

Computation and Language · Computer Science 2025-04-01 Yichun Feng , Jiawei Wang , Ruikun He , Lu Zhou , Yixue Li

Large language models (LLMs) have achieved remarkable success across a wide range of applications especially when augmented by external knowledge through retrieval-augmented generation (RAG). Despite their widespread adoption, recent…

Computation and Language · Computer Science 2026-04-14 Tianzhe Zhao , Jiaoyan Chen , Shuxiu Zhang , Haiping Zhu , Qika Lin , Jun Liu

Understanding complex biomolecular mechanisms requires multi-step reasoning across molecular interactions, signaling cascades, and metabolic pathways. While large language models(LLMs) show promise in such tasks, their application to…

Artificial Intelligence · Computer Science 2025-11-12 Tianwen Lyu , Xiang Zhuang , Keyan Ding , Xinzhe Cao , Lei Liang , Wei Zhao , Qiang Zhang , Huajun Chen

Large Language Models (LLMs) have shown impressive potential in clinical question answering (QA), with Retrieval Augmented Generation (RAG) emerging as a leading approach for ensuring the factual accuracy of model responses. However,…

Computation and Language · Computer Science 2025-07-21 Mohita Chowdhury , Yajie Vera He , Jared Joselowitz , Aisling Higham , Ernest Lim

We present LinkQ, a system that leverages a large language model (LLM) to facilitate knowledge graph (KG) query construction through natural language question-answering. Traditional approaches often require detailed knowledge of a graph…

Computation and Language · Computer Science 2025-02-11 Harry Li , Gabriel Appleby , Ashley Suh

Integrating structured knowledge from Knowledge Graphs (KGs) into Large Language Models (LLMs) enhances factual grounding and reasoning capabilities. This survey paper systematically examines the synergy between KGs and LLMs, categorizing…

Computation and Language · Computer Science 2025-06-12 Blaž Škrlj , Boshko Koloski , Senja Pollak , Nada Lavrač

Large Language Models (LLMs) and Knowledge Graphs (KGs) offer a promising approach to robust and explainable Question Answering (QA). While LLMs excel at natural language understanding, they suffer from knowledge gaps and hallucinations.…

Machine Learning · Computer Science 2025-04-15 Jasper Linders , Jakub M. Tomczak

The advent of large language models (LLMs) has significantly advanced natural language processing tasks like text summarization. However, their large size and computational demands, coupled with privacy concerns in data transmission, limit…

Computation and Language · Computer Science 2024-03-18 Pengcheng Jiang , Cao Xiao , Zifeng Wang , Parminder Bhatia , Jimeng Sun , Jiawei Han

Although large language models (LLMs) often produce impressive outputs, it remains unclear how they perform in real-world scenarios requiring strong reasoning skills and expert domain knowledge. We set out to investigate whether close- and…

Computation and Language · Computer Science 2023-12-27 Valentin Liévin , Christoffer Egeberg Hother , Andreas Geert Motzfeldt , Ole Winther

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Large Language Models (LLMs) have demonstrated impressive performance in natural language processing tasks by leveraging chain of thought (CoT) that enables step-by-step thinking. Extending LLMs with multimodal capabilities is the recent…

Computation and Language · Computer Science 2024-01-24 Debjyoti Mondal , Suraj Modi , Subhadarshi Panda , Rituraj Singh , Godawari Sudhakar Rao

While Large Language Models (LLMs) achieve expert-level performance on standard medical benchmarks through single-hop factual recall, they severely struggle with the complex, multi-hop diagnostic reasoning required in real-world clinical…

Computation and Language · Computer Science 2026-03-16 Xing Zi , Xinying Zhou , Jinghao Xiao , Catarina Moreira , Mukesh Prasad

Large Language Models (LLMs) often exhibit factual inconsistencies and logical decay in extended, multi-turn dialogues, a challenge stemming from their reliance on static, pre-trained knowledge and an inability to reason adaptively over the…

Computation and Language · Computer Science 2025-10-16 Xiang Lei , Qin Li , Min Zhang , Min Zhang

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

While large language models (LLMs) have demonstrated impressive capabilities across various natural language processing tasks by acquiring rich factual knowledge from their broad training data, their ability to synthesize and logically…

Computation and Language · Computer Science 2024-07-31 Tianshi Zheng , Jiaxin Bai , Yicheng Wang , Tianqing Fang , Yue Guo , Yauwai Yim , Yangqiu Song

Large language models (LLMs) have recently showcased remarkable capabilities, spanning a wide range of tasks and applications, including those in the medical domain. Models like GPT-4 excel in medical question answering but may face…

Computation and Language · Computer Science 2025-07-02 Bowen Wang , Jiuyang Chang , Yiming Qian , Guoxin Chen , Junhao Chen , Zhouqiang Jiang , Jiahao Zhang , Yuta Nakashima , Hajime Nagahara

The integration of Large Language Models (LLMs) into biomedical research offers new opportunities for domainspecific reasoning and knowledge representation. However, their performance depends heavily on the semantic quality of training…

This study investigates the effectiveness of Large Language Models (LLMs) for the extraction of structured knowledge in the form of Subject-Predicate-Object triples. We apply the setup for the domain of Economics application. The findings…

Computation and Language · Computer Science 2025-10-08 Durgesh Nandini , Rebekka Koch , Mirco Schoenfeld
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