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Clinical decisions are high-stakes and require explicit justification, making model interpretability essential for auditing deep clinical models prior to deployment. As the ecosystem of model architectures and explainability methods…

Machine Learning · Computer Science 2026-03-27 Yongda Fan , John Wu , Andrea Fitzpatrick , Naveen Baskaran , Jimeng Sun , Adam Cross

For reliability, it is important that the predictions made by machine learning methods are interpretable by human. In general, deep neural networks (DNNs) can provide accurate predictions, although it is difficult to interpret why such…

Machine Learning · Computer Science 2021-12-16 Yuya Yoshikawa , Tomoharu Iwata

Learning-based signal processing systems increasingly support high-stakes medical decisions using heterogeneous biomedical signals, including medical images, physiological time series, and clinical records. Despite strong predictive…

Signal Processing · Electrical Eng. & Systems 2026-03-02 Surajit Das , Maxine Tan

Large language models (LLMs) excel at handling human queries, but they can occasionally generate flawed or unexpected responses. Understanding their internal states is crucial for understanding their successes, diagnosing their failures,…

Computation and Language · Computer Science 2025-02-24 Xuansheng Wu , Jiayi Yuan , Wenlin Yao , Xiaoming Zhai , Ninghao Liu

Machine/deep learning models have been widely adopted for predicting the configuration performance of software systems. However, a crucial yet unaddressed challenge is how to cater for the sparsity inherited from the configuration…

Software Engineering · Computer Science 2024-11-21 Jingzhi Gong , Tao Chen , Rami Bahsoon

Interpretability allows the domain-expert to directly evaluate the model's relevance and reliability, a practice that offers assurance and builds trust. In the healthcare setting, interpretable models should implicate relevant biological…

Machine Learning · Computer Science 2020-06-18 Thomas P. Quinn , Dang Nguyen , Santu Rana , Sunil Gupta , Svetha Venkatesh

Internal activations of diffusion models encode rich semantic information, but interpreting such representations remains challenging. While Sparse Autoencoders (SAEs) have shown promise in disentangling latent representations, existing…

Machine Learning · Computer Science 2026-01-23 Zhenghao He , Guangzhi Xiong , Boyang Wang , Sanchit Sinha , Aidong Zhang

The Lasso has become a benchmark data analysis procedure, and numerous variants have been proposed in the literature. Although the Lasso formulations are stated so that overall prediction error is optimized, no full control over the…

As machine learning models are increasingly deployed in high-stakes domains, the need for interpretability has grown to meet strict regulatory and accountability constraints. Despite this interest, systematic evaluations of inherently…

Machine Learning · Computer Science 2026-03-27 Mattia Billa , Giovanni Orlandi , Veronica Guidetti , Federica Mandreoli

Building generalizable AI models is one of the primary challenges in the healthcare domain. While radiologists rely on generalizable descriptive rules of abnormality, Neural Network (NN) models suffer even with a slight shift in input…

Computer Vision and Pattern Recognition · Computer Science 2023-07-12 Shantanu Ghosh , Ke Yu , Kayhan Batmanghelich

As large language models (LLMs) become increasingly embedded in everyday applications, ensuring their alignment with the diverse preferences of individual users has become a critical challenge. Currently deployed approaches typically assume…

Machine Learning · Computer Science 2024-12-19 Katarzyna Kobalczyk , Claudio Fanconi , Hao Sun , Mihaela van der Schaar

Sleep quality is influenced by a complex interplay of behavioral, environmental, and psychosocial factors, yet most computational studies focus mainly on predictive risk identification rather than actionable intervention design. Although…

Machine Learning · Computer Science 2026-03-19 Mahfuz Ahmed Anik , Mohsin Mahmud Topu , Azmine Toushik Wasi , Md Isfar Khan , MD Manjurul Ahsan

Foundation large language models (LLMs) have shown an impressive ability to solve tasks across a wide range of fields including health. To effectively solve personalized health tasks, LLMs need the ability to ingest a diversity of data…

Stress is widely recognized as a major contributor to a variety of health issues. Stress prediction using biosignal data recorded by wearables is a key area of study in mobile sensing research because real-time stress prediction can enable…

Machine Learning · Computer Science 2023-08-14 Tanvir Islam , Peter Washington

Supervised Machine Learning (SML) algorithms such as Gradient Boosting, Random Forest, and Neural Networks have become popular in recent years due to their increased predictive performance over traditional statistical methods. This is…

Machine Learning · Statistics 2018-06-05 Linwei Hu , Jie Chen , Vijayan N. Nair , Agus Sudjianto

The incorporation of generative artificial intelligence into personal health applications presents a transformative opportunity for personalized, data-driven health and fitness guidance, yet also poses challenges related to user safety,…

Sparse autoencoders (SAEs) are a popular method for interpreting concepts represented in large language model (LLM) activations. However, there is a lack of evidence regarding the validity of their interpretations due to the lack of a…

Machine Learning · Computer Science 2025-02-25 Subhash Kantamneni , Joshua Engels , Senthooran Rajamanoharan , Max Tegmark , Neel Nanda

Respiratory diseases remain major global health challenges, and traditional auscultation is often limited by subjectivity, environmental noise, and inter-clinician variability. This study presents an explainable multimodal deep learning…

Sound · Computer Science 2025-12-02 S M Asiful Islam Saky , Md Rashidul Islam , Md Saiful Arefin , Shahaba Alam

The effectiveness of self-supervised learning (SSL) for physiological time series depends on the ability of a pretraining objective to preserve information about the underlying physiological state while filtering out unrelated noise.…

Machine Learning · Computer Science 2025-12-02 Yenho Chen , Maxwell A. Xu , James M. Rehg , Christopher J. Rozell

Large language models possess strong chemical reasoning capabilities, making them effective molecular editors. However, property-relevant information is implicitly entangled across their dense hidden states, providing no explicit handle for…

Machine Learning · Computer Science 2026-05-12 Mingxu Zhang , Yuhan Li , Lujundong Li , Dazhong Shen , Hui Xiong , Ying Sun
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