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Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the internal representations of large language models (LLMs), revealing latent latent features with semantical meaning. This interpretability has also…

Other Quantitative Biology · Quantitative Biology 2025-07-11 Haoxiang Guan , Jiyan He , Jie Zhang

The rapid advancements in transformer-based language models have revolutionized natural language processing, yet understanding the internal mechanisms of these models remains a significant challenge. This paper explores the application of…

Machine Learning · Computer Science 2025-02-14 Edith Natalia Villegas Garcia , Alessio Ansuini

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from…

Quantitative Methods · Quantitative Biology 2026-01-21 Xiangyu Liu , Haodi Lei , Yi Liu , Yang Liu , Wei Hu

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster

Large Language Models (LLMs) have transformed natural language processing, yet their internal mechanisms remain largely opaque. Recently, mechanistic interpretability has attracted significant attention from the research community as a…

Machine Learning · Computer Science 2025-09-24 Dong Shu , Xuansheng Wu , Haiyan Zhao , Daking Rai , Ziyu Yao , Ninghao Liu , Mengnan Du

Sparse Autoencoders (SAEs) have emerged as a popular tool for interpreting the hidden states of large language models (LLMs). By learning to reconstruct activations from a sparse bottleneck layer, SAEs discover interpretable features from…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Matthew Lyle Olson , Musashi Hinck , Neale Ratzlaff , Changbai Li , Phillip Howard , Vasudev Lal , Shao-Yen Tseng

Pathology plays an important role in disease diagnosis, treatment decision-making and drug development. Previous works on interpretability for machine learning models on pathology images have revolved around methods such as attention value…

While the activations of neurons in deep neural networks usually do not have a simple human-understandable interpretation, sparse autoencoders (SAEs) can be used to transform these activations into a higher-dimensional latent space which…

Machine Learning · Computer Science 2025-08-07 Gonçalo Paulo , Alex Mallen , Caden Juang , Nora Belrose

Sparse Autoencoders (SAEs) provide potentials for uncovering structured, human-interpretable representations in Large Language Models (LLMs), making them a crucial tool for transparent and controllable AI systems. We systematically analyze…

Machine Learning · Computer Science 2026-02-03 Jack Gallifant , Shan Chen , Kuleen Sasse , Hugo Aerts , Thomas Hartvigsen , Danielle S. Bitterman

Protein language models have revolutionized structure prediction, but their nonlinear nature obscures how sequence representations inform structure prediction. While sparse autoencoders (SAEs) offer a path to interpretability here by…

Biomolecules · Quantitative Biology 2025-03-13 Nithin Parsan , David J. Yang , John J. Yang

Sparse autoencoders (SAEs) have shown promise in extracting interpretable features from complex neural networks. We present one of the first applications of SAEs to dense text embeddings from large language models, demonstrating their…

Machine Learning · Computer Science 2024-08-06 Charles O'Neill , Christine Ye , Kartheik Iyer , John F. Wu

Vision foundation models (FMs) achieve state-of-the-art performance in medical imaging. However, they encode information in abstract latent representations that clinicians cannot interrogate or verify. The goal of this study is to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Philipp Wesp , Robbie Holland , Vasiliki Sideri-Lampretsa , Sergios Gatidis

Recent LLMs like DeepSeek-R1 have demonstrated state-of-the-art performance by integrating deep thinking and complex reasoning during generation. However, the internal mechanisms behind these reasoning processes remain unexplored. We…

Computation and Language · Computer Science 2025-08-07 Andrey Galichin , Alexey Dontsov , Polina Druzhinina , Anton Razzhigaev , Oleg Y. Rogov , Elena Tutubalina , Ivan Oseledets

Mechanistic interpretability of large language models (LLMs) aims to uncover the internal processes of information propagation and reasoning. Sparse autoencoders (SAEs) have demonstrated promise in this domain by extracting interpretable…

Machine Learning · Computer Science 2025-05-26 Wei Shi , Sihang Li , Tao Liang , Mingyang Wan , Guojun Ma , Xiang Wang , Xiangnan He

Sparse autoencoders (SAEs) are a mechanistic interpretability technique that have been used to provide insight into learned concepts within large protein language models. Here, we employ TopK and Ordered SAEs to investigate autoregressive…

Large Language Models (LLMs) have achieved strong complex reasoning capabilities through Chain-of-Thought (CoT) reasoning. However, their reasoning patterns remain too complicated to analyze. While Sparse Autoencoders (SAEs) have emerged as…

Machine Learning · Computer Science 2026-03-04 Xuan Yang , Jiayu Liu , Yuhang Lai , Hao Xu , Zhenya Huang , Ning Miao

Sparse autoencoders (SAEs) provide a powerful mechanism for decomposing the dense representations produced by Large Language Models (LLMs) into interpretable latent features. We posit that SAEs constitute a natural foundation for Learned…

Machine Learning · Computer Science 2026-03-17 Thibault Formal , Maxime Louis , Hervé Dejean , Stéphane Clinchant

Understanding the multilingual mechanisms of large language models (LLMs) provides insight into how they process different languages, yet this remains challenging. Existing studies often focus on individual neurons, but their polysemantic…

Understanding the internal machinations of deep Transformer-based NLP models is more crucial than ever as these models see widespread use in various domains that affect the public at large, such as industry, academia, finance, health. While…

Computation and Language · Computer Science 2026-05-13 Dan Pluth , Zachary Nicholas Houghton , Yu Zhou , Vijay K. Gurbani

Radiological services are experiencing unprecedented demand, leading to increased interest in automating radiology report generation. Existing Vision-Language Models (VLMs) suffer from hallucinations, lack interpretability, and require…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Ahmed Abdulaal , Hugo Fry , Nina Montaña-Brown , Ayodeji Ijishakin , Jack Gao , Stephanie Hyland , Daniel C. Alexander , Daniel C. Castro
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