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Related papers: BioinfoMCP: A Unified Platform Enabling MCP Interf…

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Bioinformatics web servers are critical resources in modern biomedical research, facilitating interactive exploration of datasets through custom-built interfaces with rich visualization capabilities. However, this human-centric design…

Other Quantitative Biology · Quantitative Biology 2026-02-25 Matthias Flotho , Ian Ferenc Diks , Philipp Flotho , Leidy-Alejandra G. Molano , Pascal Hirsch , Andreas Keller

Current AI agents create significant barriers for users by requiring extensive processing to understand web pages, making AI-assisted web interaction slow and expensive. This paper introduces webMCP (Web Machine Context & Procedure), a…

Networking and Internet Architecture · Computer Science 2025-08-14 D. Perera

Tool calling has emerged as a critical capability for AI agents. In contrast to conventional tool calling frameworks that rely on static, provider-specific tool definitions, the Model Context Protocol (MCP) offers a unified interface to…

This paper introduces Agentic-AI Healthcare, a privacy-aware, multilingual, and explainable research prototype developed as a single-investigator project. The system leverages the emerging Model Context Protocol (MCP) to orchestrate…

Cryptography and Security · Computer Science 2025-10-06 Mohammed A. Shehab

The Model Context Protocol (MCP) is rapidly emerging as a pivotal open standard, designed to enhance agent-tool integration and interoperability, and is positioned to unlock a new era of powerful, interconnected, and genuinely utilitarian…

Computation and Language · Computer Science 2025-09-15 Zikang Guo , Benfeng Xu , Chiwei Zhu , Wentao Hong , Xiaorui Wang , Zhendong Mao

The Model Context Protocol (MCP) enables large language models to invoke external tools through natural-language descriptions, forming the foundation of many AI agent applications. However, MCP does not enforce consistency between…

Cryptography and Security · Computer Science 2026-02-04 Zhihao Li , Boyang Ma , Xuelong Dai , Minghui Xu , Yue Zhang , Biwei Yan , Kun Li

The Model Context Protocol (MCP) is emerging as a standard interface through which large language model (LLM) agents discover and invoke external tools. However, existing MCP evaluations fall short along three key axes: realistic multi-step…

Model Context Protocol (MCP) has become a key infrastructure for connecting LLMs with external tools, scaling to 10,000+ MCP servers with diverse tools. Unfortunately, there is still a large gap between real-world MCP usage and current…

Artificial Intelligence · Computer Science 2026-02-27 Guozhao Mo , Wenliang Zhong , Jiawei Chen , Qianhao Yuan , Xuanang Chen , Yaojie Lu , Hongyu Lin , Ben He , Xianpei Han , Le Sun

Large language model (LLM)-powered agents are increasingly used to plan and execute scientific workflows, yet most research cyberinfrastructure (CI) exposes heterogeneous APIs and implements security models that present barriers for use by…

The Model Context Protocol (MCP), introduced by Anthropic in November 2024 and now governed by the Linux Foundation's Agentic AI Foundation, has rapidly become the de facto standard for connecting large language model (LLM)-based agents to…

Cryptography and Security · Computer Science 2026-04-08 Nirajan Acharya , Gaurav Kumar Gupta

The Model Context Protocol (MCP) standardizes how AI agents discover and invoke external tools, with over 10,000 active servers and 97 million monthly SDK downloads as of early 2026. Yet MCP does not yet standardize how agents safely…

Software Engineering · Computer Science 2026-04-16 Vasundra Srinivasan

Agentic AI systems built around large language models (LLMs) are moving away from closed, single-model frameworks and toward open ecosystems that connect a variety of agents, external tools, and resources. The Model Context Protocol (MCP)…

Cryptography and Security · Computer Science 2026-02-03 Xinyi Hou , Shenao Wang , Yifan Zhang , Ziluo Xue , Yanjie Zhao , Cai Fu , Haoyu Wang

Backgrounds: Artificial intelligence (AI) is transforming healthcare, yet translating AI models from theoretical frameworks to real-world clinical applications remains challenging. The Mayo Clinic Platform (MCP) was established to address…

The Model Context Protocol (MCP) has recently emerged as a standardized interface for connecting language models with external tools and data. As the ecosystem rapidly expands, the lack of a structured, comprehensive view of existing MCP…

Cryptography and Security · Computer Science 2025-07-01 Zhiwei Lin , Bonan Ruan , Jiahao Liu , Weibo Zhao

We introduce MCP-Bench, a benchmark for evaluating large language models (LLMs) on realistic, multi-step tasks that demand tool use, cross-tool coordination, precise parameter control, and planning/reasoning for solving tasks. Built on the…

Computation and Language · Computer Science 2025-08-29 Zhenting Wang , Qi Chang , Hemani Patel , Shashank Biju , Cheng-En Wu , Quan Liu , Aolin Ding , Alireza Rezazadeh , Ankit Shah , Yujia Bao , Eugene Siow

Large Language Models (LLMs) increasingly rely on external tools to perform complex, realistic tasks, yet their ability to utilize the rapidly expanding Model Contextual Protocol (MCP) ecosystem remains limited. Existing MCP research covers…

Artificial Intelligence · Computer Science 2026-04-17 Wenhao Wang , Peizhi Niu , Zhao Xu , Zhaoyu Chen , Jian Du , Yaxin Du , Xianghe Pang , Keduan Huang , Yanfeng Wang , Qiang Yan , Siheng Chen

The Model Context Protocol (MCP) is a recently proposed interoperability standard that unifies how AI agents connect with external tools and data sources. By defining a set of common client-server message exchange clauses, MCP replaces…

Cryptography and Security · Computer Science 2026-03-12 Nanzi Yang , Weiheng Bai , Kangjie Lu

Current LLM agents are proficient at calling isolated APIs but struggle with the "last mile" of commercial software automation. In real-world scenarios, tools are not independent; they are atomic, interdependent, and prone to environmental…

Artificial Intelligence · Computer Science 2026-05-21 Yuanyang Li , Xue Yang , Longyue Wang , Weihua Luo , Hongyang Chen

LLMs' capabilities are enhanced by using function calls to integrate various data sources or API results into the context window. Typical tools include search, web crawlers, maps, financial data, file systems, and browser usage, etc.…

Artificial Intelligence · Computer Science 2025-08-12 Shiqing Fan , Xichen Ding , Liang Zhang , Linjian Mo

Large language model powered autonomous agents demand robust, standardized protocols to integrate tools, share contextual data, and coordinate tasks across heterogeneous systems. Ad-hoc integrations are difficult to scale, secure, and…

Artificial Intelligence · Computer Science 2025-05-26 Abul Ehtesham , Aditi Singh , Gaurav Kumar Gupta , Saket Kumar
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