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Advancements in generative Artificial Intelligence (AI) hold great promise for automating radiology workflows, yet challenges in interpretability and reliability hinder clinical adoption. This paper presents an automated radiology report…

Machine learning accelerates molecular property prediction, yet state-of-the-art Large Language Models and Graph Neural Networks operate as black boxes. In drug discovery, where safety is critical, this opacity risks masking false…

Machine Learning · Computer Science 2026-03-03 Oscar Rivera , Ziqing Wang , Matthieu Dagommer , Abhishek Pandey , Kaize Ding

Concept Bottleneck Models (CBMs) are a prominent framework for interpretable AI that map learned visual features to a set of meaningful concepts for task-specific downstream predictions. Their sequential structure enhances transparency by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Mohamed Harmanani , Bining Long , Zhuoxin Guo , Paul F. R. Wilson , Amirhossein Sabour , Minh Nguyen Nhat To , Gabor Fichtinger , Purang Abolmaesumi , Parvin Mousavi

Advancements in foundation models (FMs) have led to a paradigm shift in machine learning. The rich, expressive feature representations from these pre-trained, large-scale FMs are leveraged for multiple downstream tasks, usually via…

Machine Learning · Computer Science 2024-12-19 Jihye Choi , Jayaram Raghuram , Yixuan Li , Somesh Jha

Concept Bottleneck Models (CBMs) provide interpretable prediction by introducing an intermediate Concept Bottleneck Layer (CBL), which encodes human-understandable concepts to explain models' decision. Recent works proposed to utilize Large…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Divyansh Srivastava , Ge Yan , Tsui-Wei Weng

We introduce Concept Bottleneck Reward Models (CB-RM), a reward modeling framework that enables interpretable preference learning through selective concept annotation. Unlike standard RLHF methods that rely on opaque reward functions, CB-RM…

Machine Learning · Computer Science 2025-07-22 Sonia Laguna , Katarzyna Kobalczyk , Julia E. Vogt , Mihaela Van der Schaar

Concept Bottleneck Models (CBMs) introduce interpretability to black-box deep learning models by predicting labels through human-understandable concepts. However, unlike humans, who identify objects at different levels of abstraction using…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Haodong Xie , Yujun Cai , Rahul Singh Maharjan , Yiwei Wang , Federico Tavella , Angelo Cangelosi

Models based on human-understandable concepts have received extensive attention to improve model interpretability for trustworthy artificial intelligence in the field of medical image analysis. These methods can provide convincing…

Computer Vision and Pattern Recognition · Computer Science 2024-12-25 Hongmei Wang , Junlin Hou , Hao Chen

Continual learning (CL) aims to enable learning systems to acquire new knowledge constantly without forgetting previously learned information. CL faces the challenge of mitigating catastrophic forgetting while maintaining interpretability…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Lu Yu , Haoyu Han , Zhe Tao , Hantao Yao , Changsheng Xu

We introduce Concept Bottleneck Protein Language Models (CB-pLM), a generative masked language model with a layer where each neuron corresponds to an interpretable concept. Our architecture offers three key benefits: i) Control: We can…

The lack of transparency in the decision-making processes of deep learning systems presents a significant challenge in modern artificial intelligence (AI), as it impairs users' ability to rely on and verify these systems. To address this…

Artificial Intelligence · Computer Science 2024-11-18 David Debot , Pietro Barbiero , Francesco Giannini , Gabriele Ciravegna , Michelangelo Diligenti , Giuseppe Marra

Deep learning has advanced medical image classification, but interpretability challenges hinder its clinical adoption. This study enhances interpretability in Chest X-ray (CXR) classification by using concept bottleneck models (CBMs) and a…

Information Retrieval · Computer Science 2025-04-30 Hasan Md Tusfiqur Alam , Devansh Srivastav , Md Abdul Kadir , Daniel Sonntag

There has been considerable recent interest in interpretable concept-based models such as Concept Bottleneck Models (CBMs), which first predict human-interpretable concepts and then map them to output classes. To reduce reliance on…

Machine Learning · Computer Science 2024-07-08 Simon Schrodi , Julian Schur , Max Argus , Thomas Brox

Concept Bottleneck Models (CBMs) offer interpretable alternatives to black-box predictors by introducing human-relatable concepts before the final output. However, existing CBMs struggle to verify whether predicted concepts correspond to…

Machine Learning · Computer Science 2026-05-15 Yingying Fang , Haijie Xu , Shuang Wu , Mariathasan Anish , Guang Yang

Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Winnie Pang , Xueyi Ke , Satoshi Tsutsui , Bihan Wen

We introduce Concept Bottleneck Large Language Models (CB-LLMs), a novel framework for building inherently interpretable Large Language Models (LLMs). In contrast to traditional black-box LLMs that rely on limited post-hoc interpretations,…

Computation and Language · Computer Science 2025-09-09 Chung-En Sun , Tuomas Oikarinen , Berk Ustun , Tsui-Wei Weng

Concept bottleneck models (CBMs) improve neural network interpretability by introducing an intermediate layer that maps human-understandable concepts to predictions. Recent work has explored the use of vision-language models (VLMs) to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Xingbo Du , Qiantong Dou , Lei Fan , Rui Zhang

Concept-bottleneck models (CBMs) are neural classifiers that compute predictions from high-level concepts extracted from the input. CBMs ensure stakeholders can understand the concepts -- and the predictions they entail -- by learning these…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Nicola Debole , Andrea Passerini , Stefano Teso , Andrea Pugnana , Emanuele Marconato

Concept bottleneck models (CBM) aim to produce inherently interpretable models that rely on human-understandable concepts for their predictions. However, existing approaches to design interpretable generative models based on CBMs are not…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Akshay Kulkarni , Ge Yan , Chung-En Sun , Tuomas Oikarinen , Tsui-Wei Weng

Deep learning approaches have recently been extensively explored for the prognostics of industrial assets. However, they still suffer from a lack of interpretability, which hinders their adoption in safety-critical applications. To improve…

Machine Learning · Computer Science 2024-05-29 Florent Forest , Katharina Rombach , Olga Fink
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