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Large language models (LLMs) have achieved strong empirical performance in various fields, benefiting from their huge amount of parameters that store knowledge. However, LLMs still suffer from several key issues, such as hallucination…

Computation and Language · Computer Science 2026-05-20 Shangyu Wu , Ying Xiong , Yufei Cui , Haolun Wu , Can Chen , Ye Yuan , Lianming Huang , Xue Liu , Tei-Wei Kuo , Nan Guan , Chun Jason Xue

Large Language Models (LLMs) are transforming scientific hypothesis generation and validation by enabling information synthesis, latent relationship discovery, and reasoning augmentation. This survey provides a structured overview of…

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

We present RAM-EHR, a Retrieval AugMentation pipeline to improve clinical predictions on Electronic Health Records (EHRs). RAM-EHR first collects multiple knowledge sources, converts them into text format, and uses dense retrieval to obtain…

Computation and Language · Computer Science 2024-07-30 Ran Xu , Wenqi Shi , Yue Yu , Yuchen Zhuang , Bowen Jin , May D. Wang , Joyce C. Ho , Carl Yang

Despite the significant progress of large language models (LLMs) in various tasks, they often produce factual errors due to their limited internal knowledge. Retrieval-Augmented Generation (RAG), which enhances LLMs with external knowledge…

Computation and Language · Computer Science 2024-10-10 Yuanjie Lyu , Zihan Niu , Zheyong Xie , Chao Zhang , Tong Xu , Yang Wang , Enhong Chen

Large language models (LLMs) have demonstrated remarkable capabilities in a wide range of tasks, yet their application to specialized domains remains challenging due to the need for deep expertise. Retrieval-Augmented generation (RAG) has…

Computation and Language · Computer Science 2025-09-30 Qinggang Zhang , Shengyuan Chen , Yuanchen Bei , Zheng Yuan , Huachi Zhou , Zijin Hong , Hao Chen , Yilin Xiao , Chuang Zhou , Junnan Dong , Yi Chang , Xiao Huang

Large Language Models (LLMs) are prone to generating factually incorrect information when responding to queries that involve numerical and statistical data or other timely facts. In this paper, we present an approach for enhancing the…

Computation and Language · Computer Science 2024-09-24 Prashanth Radhakrishnan , Jennifer Chen , Bo Xu , Prem Ramaswami , Hannah Pho , Adriana Olmos , James Manyika , R. V. Guha

Generating high-quality answers consistently by providing contextual information embedded in the prompt passed to the Large Language Model (LLM) is dependent on the quality of information retrieval. As the corpus of contextual information…

Information Retrieval · Computer Science 2024-08-01 Sai Ganesh , Anupam Purwar , Gautam B

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

Machine Learning · Computer Science 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

Large Language Models (LLMs) excel at reasoning and generation but are inherently limited by static pretraining data, resulting in factual inaccuracies and weak adaptability to new information. Retrieval-Augmented Generation (RAG) addresses…

Computation and Language · Computer Science 2025-11-03 Qi Luo , Xiaonan Li , Yuxin Wang , Tingshuo Fan , Yuan Li , Xinchi Chen , Xipeng Qiu

Although the rise of large language models (LLMs) has introduced new opportunities for time series forecasting, existing LLM-based solutions require excessive training and exhibit limited transferability. In view of these challenges, we…

Artificial Intelligence · Computer Science 2024-12-24 Silin Yang , Dong Wang , Haoqi Zheng , Ruochun Jin

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

The emergence of advanced reasoning capabilities in Large Language Models (LLMs) marks a transformative development in healthcare applications. Beyond merely expanding functional capabilities, these reasoning mechanisms enhance decision…

Artificial Intelligence · Computer Science 2025-08-27 Armin Berger , Sarthak Khanna , David Berghaus , Rafet Sifa

This study presents a method for implementing generative AI services by utilizing the Large Language Models (LLM) application architecture. With recent advancements in generative AI technology, LLMs have gained prominence across various…

Artificial Intelligence · Computer Science 2024-01-03 Cheonsu Jeong

Screening patients for clinical trial eligibility remains a manual, time-consuming, and resource-intensive process. We present a secure, scalable proof-of-concept system for Artificial Intelligence (AI)-augmented patient-trial matching that…

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Large Language Models(LLMs) hold promise for improving healthcare access in low-resource settings, but their effectiveness in African primary care remains underexplored. We present a methodology for creating a benchmark dataset and…

Retrieval Augmented Generation (RAG) has emerged as a powerful application of Large Language Models (LLMs), revolutionizing information search and consumption. RAG systems combine traditional search capabilities with LLMs to generate…

Information Retrieval · Computer Science 2025-06-12 Harsh Maheshwari , Srikanth Tenneti , Alwarappan Nakkiran

Developing the capacity to effectively search for requisite datasets is an urgent requirement to assist data users in identifying relevant datasets considering the very limited available metadata. For this challenge, the utilization of…

Information Retrieval · Computer Science 2024-10-08 Teruaki Hayashi , Hiroki Sakaji , Jiayi Dai , Randy Goebel

Large language models (LLMs) encode vast world knowledge in their parameters, yet they remain fundamentally limited by static knowledge, finite context windows, and weakly structured causal reasoning. This survey provides a unified account…

Computation and Language · Computer Science 2026-04-06 Prakhar Bansal , Shivangi Agarwal
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