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This article discusses the opportunities, applications and future directions of large-scale pre-trained models, i.e., foundation models, for analyzing medical images. Medical foundation models have immense potential in solving a wide range…

Image and Video Processing · Electrical Eng. & Systems 2023-11-23 Shaoting Zhang , Dimitris Metaxas

In this study, we aim to initiate the development of Radiology Foundation Model, termed as RadFM. We consider the construction of foundational models from three perspectives, namely, dataset construction, model design, and thorough…

Computer Vision and Pattern Recognition · Computer Science 2023-11-17 Chaoyi Wu , Xiaoman Zhang , Ya Zhang , Yanfeng Wang , Weidi Xie

The electrocardiogram (ECG) is an essential and effective tool for diagnosing heart diseases. However, its effectiveness can be compromised by noise or unavailability of one or more leads of the standard 12-lead recordings, resulting in…

Machine Learning · Computer Science 2025-10-07 Huynh Dang Nguyen , Trong-Thang Pham , Ngan Le , Van Nguyen

Cardiovascular disease remains the leading cause of global mortality, yet scalable cardiac monitoring is hindered by the gap between diagnostic-rich ECG and ubiquitous wearable PPG. Bridging this gap requires representations that are…

Machine Learning · Computer Science 2026-05-12 Zhangdaihong Liu , Chang Liu , Fenglin Liu , Yixuan Chen , Yang Yang , David A. Clifton , Xiao Gu

In hematology, computational models offer significant potential to improve diagnostic accuracy, streamline workflows, and reduce the tedious work of analyzing single cells in peripheral blood or bone marrow smears. However, clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Valentin Koch , Sophia J. Wagner , Salome Kazeminia , Ece Sancar , Matthias Hehr , Julia Schnabel , Tingying Peng , Carsten Marr

Foundation models have demonstrated remarkable potential in medical domain. However, their application to complex cardiovascular diagnostics remains underexplored. In this paper, we present Cardiac-CLIP, a multi-modal foundation model…

Electrocardiogram (ECG) is a widely used tool for assessing cardiac function due to its low cost and accessibility. Emergent research shows that ECGs can help make predictions on key outcomes traditionally derived from more complex…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Chris McIntosh

Echocardiography (echo) is an ultrasound imaging modality that is widely used for various cardiovascular diagnosis tasks. Due to inter-observer variability in echo-based diagnosis, which arises from the variability in echo image acquisition…

Computer Vision and Pattern Recognition · Computer Science 2023-08-28 Masoud Mokhtari , Neda Ahmadi , Teresa S. M. Tsang , Purang Abolmaesumi , Renjie Liao

Echocardiography (ECHO) video is widely used for cardiac examination. In clinical, this procedure heavily relies on operator experience, which needs years of training and maybe the assistance of deep learning-based systems for enhanced…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Xinrui Zhou , Yuhao Huang , Wufeng Xue , Haoran Dou , Jun Cheng , Han Zhou , Dong Ni

Structural heart disease (SHD) is a prevalent condition with many undiagnosed cases, and early detection is often limited by the high cost and accessibility constraints of echocardiography (ECHO). Recent studies show that artificial…

Applications · Statistics 2026-03-04 Ya Zhou , Zhaohong Sun , Tianxiang Hao , Xiangjie Li

Foundation models have achieved remarkable success across various domains, yet their adoption in healthcare remains limited. While significant advances have been made in medical imaging, genetic biomarkers, and time series from electronic…

Specialized foundation models are beginning to emerge in various medical subdomains, but pretraining methodologies and parametric scaling with the size of the pretraining dataset are rarely assessed systematically and in a like-for-like…

Signal Processing · Electrical Eng. & Systems 2026-05-13 M A Al-Masud , Nils Strodthoff

Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features…

Echocardiogram video plays a crucial role in analysing cardiac function and diagnosing cardiac diseases. Current deep neural network methods primarily aim to enhance diagnosis accuracy by incorporating prior knowledge, such as segmenting…

Image and Video Processing · Electrical Eng. & Systems 2024-10-29 Jiewen Yang , Yiqun Lin , Bin Pu , Jiarong Guo , Xiaowei Xu , Xiaomeng Li

Electrocardiogram (ECG) is a widely used diagnostic tool for detecting heart conditions. Rare cardiac diseases may be underdiagnosed using traditional ECG analysis, considering that no training dataset can exhaust all possible cardiac…

Computer Vision and Pattern Recognition · Computer Science 2023-08-04 Aofan Jiang , Chaoqin Huang , Qing Cao , Shuang Wu , Zi Zeng , Kang Chen , Ya Zhang , Yanfeng Wang

Cardiac image segmentation is an important step in many cardiac image analysis and modeling tasks such as motion tracking or simulations of cardiac mechanics. While deep learning has greatly advanced segmentation in clinical settings, there…

Developing foundation models in medical imaging requires continuous monitoring of downstream performance. Researchers are burdened with tracking numerous experiments, design choices, and their effects on performance, often relying on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Jan Tagscherer , Sarah de Boer , Lena Philipp , Fennie van der Graaf , Dré Peeters , Joeran Bosma , Lars Leijten , Bogdan Obreja , Ewoud Smit , Alessa Hering

Healthcare data now span EHRs, medical imaging, genomics, and wearable sensors, but most diagnostic models still process these modalities in isolation. This limits their ability to capture early, cross-modal disease signatures. This paper…

Machine Learning · Computer Science 2025-12-18 Md Talha Mohsin , Ismail Abdulrashid

The electrocardiogram (ECG) is a key diagnostic tool in cardiovascular health. Single-lead ECG recording is integrated into both clinical-grade and consumer wearables. While self-supervised pretraining of foundation models on unlabeled ECGs…

Machine Learning · Computer Science 2025-12-03 Yuxuan Shu , Peter H. Charlton , Fahim Kawsar , Jussi Hernesniemi , Mohammad Malekzadeh

Foundation models (FMs) promise to generalize medical imaging, but their effectiveness varies. It remains unclear how pre-training domain (medical vs. general), paradigm (e.g., text-guided), and architecture influence embedding quality,…

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