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\textit{Objective:} Gadolinium-based contrast agents (GBCAs) have been widely used to better visualize disease in brain magnetic resonance imaging (MRI). However, gadolinium deposition within the brain and body has raised safety concerns…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Chao Chen , Catalina Raymond , Bill Speier , Xinyu Jin , Timothy F. Cloughesy , Dieter Enzmann , Benjamin M. Ellingson , Corey W. Arnold

Recently, deep learning (DL)-based methods have been proposed for the computational reduction of gadolinium-based contrast agents (GBCAs) to mitigate adverse side effects while preserving diagnostic value. Currently, the two main challenges…

Today Gadolinium-based contrast agents (GBCA) are indispensable in Magnetic Resonance Imaging (MRI) for diagnosing various diseases. However, GBCAs are expensive and may accumulate in patients with potential side effects, thus…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Thomas Pinetz , Erich Kobler , Robert Haase , Katerina Deike-Hofmann , Alexander Radbruch , Alexander Effland

Cerebral blood volume (CBV) is a hemodynamic correlate of oxygen metabolism and reflects brain activity and function. High-resolution CBV maps can be generated using the steady-state gadolinium-enhanced MRI technique. Such a technique…

Deep learning (DL) based contrast dose reduction and elimination in MRI imaging is gaining traction, given the detrimental effects of Gadolinium-based Contrast Agents (GBCAs). These DL algorithms are however limited by the availability of…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Dayang Wang , Srivathsa Pasumarthi , Greg Zaharchuk , Ryan Chamberlain

Contrast enhancement by Gadolinium-based contrast agents (GBCAs) is a vital tool for tumor diagnosis in neuroradiology. Based on brain MRI scans of glioblastoma before and after Gadolinium administration, we address enhancement prediction…

Image and Video Processing · Electrical Eng. & Systems 2024-10-14 Moritz Piening , Fabian Altekrüger , Gabriele Steidl , Elke Hattingen , Eike Steidl

Magnetic resonance imaging (MRI) is the most sensitive technique for breast cancer detection among current clinical imaging modalities. Contrast-enhanced MRI (CE-MRI) provides superior differentiation between tumors and invaded healthy…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Tianyu Zhang , Luyi Han , Anna D'Angelo , Xin Wang , Yuan Gao , Chunyao Lu , Jonas Teuwen , Regina Beets-Tan , Tao Tan , Ritse Mann

Focused ultrasound (FUS) can be used to open the blood-brain barrier (BBB), and MRI with contrast agents can detect that opening. However, repeated use of gadolinium-based contrast agents (GBCAs) presents safety concerns to patients. This…

Quantitative Methods · Quantitative Biology 2023-01-19 P. Lee , H. Wei , A. N. Pouliopoulos , B. T. Forsyth , Y. Yang , C. Zhang , A. F. Laine , E. E. Konofagou , C. Wu , J. Guo

Objective: Gadolinium-based contrast agents (GBCAs) are commonly used in MRI scans of patients with gliomas to enhance brain tumor characterization using T1-weighted (T1W) MRI. However, there is growing concern about GBCA toxicity. This…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 Zach Eidex , Mojtaba Safari , Richard L. J. Qiu , David S. Yu , Hui-Kuo Shu , Hui Mao , Xiaofeng Yang

Gadolinium-based contrast agents (GBCAs) are central to glioma imaging but raise safety, cost, and accessibility concerns. Predicting contrast enhancement from non-contrast MRI using machine learning (ML) offers a safer alternative, as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Sajad Amiri , Shahram Taeb , Sara Gharibi , Setareh Dehghanfard , Somayeh Sadat Mehrnia , Mehrdad Oveisi , Ilker Hacihaliloglu , Arman Rahmim , Mohammad R. Salmanpour

Contrast-enhanced magnetic resonance imaging (MRI) is pivotal in the pipeline of brain tumor segmentation and analysis. Gadolinium-based contrast agents, as the most commonly used contrast agents, are expensive and may have potential side…

Image and Video Processing · Electrical Eng. & Systems 2024-06-25 Lujun Gui , Chuyang Ye , Tianyi Yan

Dynamic Contrast Enhanced Magnetic Resonance Imaging aids in the detection and assessment of tumor aggressiveness by using a Gadolinium-based contrast agent (GBCA). However, GBCA is known to have potential toxic effects. This risk can be…

Image and Video Processing · Electrical Eng. & Systems 2024-02-06 Sadhana S , Sriprabha Ramanarayanan , Arunima Sarkar , Matcha Naga Gayathri , Keerthi Ram , Mohanasankar Sivaprakasam

Deep learning has potential to automate screening, monitoring and grading of disease in medical images. Pretraining with contrastive learning enables models to extract robust and generalisable features from natural image datasets,…

The adoption of contrast agents in medical imaging protocols is crucial for accurate and timely diagnosis. While highly effective and characterized by an excellent safety profile, the use of contrast agents has its limitation, including…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Davide Bianchi , Sonia Colombo Serra , Davide Evangelista , Pengpeng Luo , Elena Morotti , Giovanni Valbusa

This paper presents a method for virtual contrast enhancement in breast MRI, offering a promising non-invasive alternative to traditional contrast agent-based DCE-MRI acquisition. Using a conditional generative adversarial network, we…

Image and Video Processing · Electrical Eng. & Systems 2025-05-15 Richard Osuala , Smriti Joshi , Apostolia Tsirikoglou , Lidia Garrucho , Walter H. L. Pinaya , Daniel M. Lang , Julia A. Schnabel , Oliver Diaz , Karim Lekadir

Objective: Gadolinium-based contrast agents (GBCAs) are commonly employed with T1w MRI to enhance lesion visualization but are restricted in patients at risk of nephrogenic systemic fibrosis and variations in GBCA administration can…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Zach Eidex , Mojtaba Safari , Jie Ding , Richard Qiu , Justin Roper , David Yu , Hui-Kuo Shu , Zhen Tian , Hui Mao , Xiaofeng Yang

Automated radiology report generation offers an effective solution to alleviate radiologists' workload. However, most existing methods focus primarily on single or fixed-view images to model current disease conditions, which limits…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Kang Liu , Zhuoqi Ma , Xiaolu Kang , Yunan Li , Kun Xie , Zhicheng Jiao , Qiguang Miao

Despite the astonishing performance of recent Large Vision-Language Models (LVLMs), these models often generate inaccurate responses. To address this issue, previous studies have focused on mitigating hallucinations by employing contrastive…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Sihyeon Kim , Boryeong Cho , Sangmin Bae , Sumyeong Ahn , Se-Young Yun

Longitudinal MRI is an important diagnostic imaging tool for evaluating the effects of treatment and monitoring disease progression. However, MRI, and particularly longitudinal MRI, is known to be time consuming. To accelerate imaging,…

Image and Video Processing · Electrical Eng. & Systems 2023-01-24 Jens Renders , Banafshe Shafieizargar , Marleen Verhoye , Jan De Beenhouwer , Arnold J. den Dekker , Jan Sijbers

Contrast-enhanced magnetic resonance imaging (CE-MRI) is crucial for tumor detection and diagnosis, but the use of gadolinium-based contrast agents (GBCAs) in clinical settings raises safety concerns due to potential health risks. To…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Linhao Li , Changhui Su , Yu Guo , Huimao Zhang , Dong Liang , Kun Shang
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