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Designing functional protein sequences that satisfy multiple desired properties is a core research focus of protein engineering. Prior methods struggle with inability or inefficiency when dealing with numerous, often conflicting,…

Biomolecules · Quantitative Biology 2026-05-08 Zitai Kong , Yifan Dong , Yixuan Wu , Zhaokang Liang , Jian Wu , Hongxia Xu

AllReduce is a technique in distributed computing which saw use in many critical applications of deep learning. Existing methods of AllReduce scheduling oftentimes lack flexibility due to being topology-specific or relying on extensive…

Networking and Internet Architecture · Computer Science 2025-03-28 Yufan Wei , Mickel Liu , Wenfei Wu

Generative models, including diffusion and flow-based models, often exhibit systematic biases that degrade sample quality, particularly in high-dimensional settings. We revisit refinement methods and show that effective bias correction can…

Machine Learning · Computer Science 2026-01-30 Xin Peng , Ang Gao

Fined-grained anomalous cell detection from affected tissues is critical for clinical diagnosis and pathological research. Single-cell sequencing data provide unprecedented opportunities for this task. However, current anomaly detection…

Machine Learning · Computer Science 2024-05-01 Kaichen Xu , Yueyang Ding , Suyang Hou , Weiqiang Zhan , Nisang Chen , Jun Wang , Xiaobo Sun

Element-wise activation functions play a critical role in deep neural networks via affecting the expressivity power and the learning dynamics. Learning-based activation functions have recently gained increasing attention and success. We…

Machine Learning · Computer Science 2020-10-05 Dengsheng Chen , Jun Li , Kai Xu

Complex single-objective bounded problems are often difficult to solve. In evolutionary computation methods, since the proposal of differential evolution algorithm in 1997, it has been widely studied and developed due to its simplicity and…

Neural and Evolutionary Computing · Computer Science 2024-04-26 Sichen Tao , Ruihan Zhao , Kaiyu Wang , Shangce Gao

Discrete normalizing flows are promising generative models with advantages such as analytical log-likelihood computation and end-to-end training. However, the architectural constraints to ensure invertibility and tractable Jacobian…

Machine Learning · Computer Science 2026-05-06 Jiaru Zhang , Juanwu Lu , Xiaoyu Wu , Ziran Wang , Ruqi Zhang

Linear recurrent neural networks enable powerful long-range sequence modeling with constant memory usage and time-per-token during inference. These architectures hold promise for streaming applications at the edge, but deployment in…

Machine Learning · Computer Science 2025-08-14 Alessandro Pierro , Steven Abreu , Jonathan Timcheck , Philipp Stratmann , Andreas Wild , Sumit Bam Shrestha

In diffusion models, samples are generated through an iterative refinement process, requiring hundreds of sequential model evaluations. Several recent methods have introduced approximations (fewer discretization steps or distillation) to…

Machine Learning · Computer Science 2024-12-12 Nikil Roashan Selvam , Amil Merchant , Stefano Ermon

We introduce a generative learning framework to model high-dimensional parametric systems using gradient guidance and virtual observations. We consider systems described by Partial Differential Equations (PDEs) discretized with structured…

Machine Learning · Computer Science 2024-08-02 Han Gao , Sebastian Kaltenbach , Petros Koumoutsakos

We introduce the Equilibrated Averaging Residual Method (EARM), a unified equilibrated flux-recovery framework for elliptic interface problems that applies to a broad class of finite element discretizations. The method is applicable in both…

Numerical Analysis · Mathematics 2026-01-06 Cuiyu He

An adaptive refinement strategy, based on an equilibrated flux a posteriori error estimator, is proposed in the context of defeaturing problems. Defeaturing consists of removing features from complex domains to simplify mesh generation and…

Numerical Analysis · Mathematics 2026-03-04 Annalisa Buffa , Denise Grappein , Rafael Vázquez

Neural networks have achieved remarkable performance across a wide range of tasks, yet they remain susceptible to adversarial perturbations, which pose significant risks in safety-critical applications. With the rise of multimodality,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Xinxin Liu , Zhongliang Guo , Siyuan Huang , Chun Pong Lau

Person re-identification (ReID) aims to re-identify a person from non-overlapping camera views. Since person ReID data contains sensitive personal information, researchers have adopted federated learning, an emerging distributed training…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-08-17 Weiming Zhuang , Yonggang Wen , Shuai Zhang

As deep neural networks are increasingly being deployed in practice, their efficiency has become an important issue. While there are compression techniques for reducing the network's size, energy consumption and computational requirement,…

Machine Learning · Computer Science 2020-01-31 Brandon Paulsen , Jingbo Wang , Chao Wang

In recent years, Diffusion Models have become the new state-of-the-art in deep generative modeling, ending the long-time dominance of Generative Adversarial Networks. Inspired by the Regularization by Denoising principle, we introduce an…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Pasquale Cascarano , Lorenzo Stacchio , Andrea Sebastiani , Alessandro Benfenati , Ulugbek S. Kamilov , Gustavo Marfia

This paper presents DetailFlow, a coarse-to-fine 1D autoregressive (AR) image generation method that models images through a novel next-detail prediction strategy. By learning a resolution-aware token sequence supervised with progressively…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Yiheng Liu , Liao Qu , Huichao Zhang , Xu Wang , Yi Jiang , Yiming Gao , Hu Ye , Xian Li , Shuai Wang , Daniel K. Du , Fangmin Chen , Zehuan Yuan , Xinglong Wu

Deep ensemble methods often improve predictive performance, yet they suffer from three practical limitations: redundancy among base models that inflates computational cost and degrades conditioning, unstable weighting under…

Machine Learning · Computer Science 2026-04-27 Noor Islam S. Mohammad , Md Muntaqim Meherab

New technologies such as Rectified Flow and Flow Matching have significantly improved the performance of generative models in the past two years, especially in terms of control accuracy, generation quality, and generation efficiency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Sen Fang , Hongbin Zhong , Yalin Feng , Yanxin Zhang , Dimitris N. Metaxas

In additive manufacturing (AM), particularly for laser-based metal AM, process optimization is crucial to the quality of products and the efficiency of production. The identification of optimal process parameters out of a vast parameter…

Materials Science · Physics 2024-07-25 Xiao Shang , Evelyn Li , Ajay Talbot , Haitao Wen , Tianyi Lyu , Jiahui Zhang , Yu Zou