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Ultrasound computed tomography (USCT) is an emerging imaging modality for breast imaging that can produce quantitative images that depict the acoustic properties of tissues. Computer-simulation studies, also known as virtual imaging trials,…

Medical Physics · Physics 2022-06-24 Fu Li , Umberto Villa , Seonyeong Park , Mark A. Anastasio

Quantitative photoacoustic computed tomography (qPACT) is a promising imaging modality for estimating physiological parameters such as blood oxygen saturation. However, developing robust qPACT reconstruction methods remains challenging due…

Medical Physics · Physics 2025-10-07 Refik Mert Cam , Seonyeong Park , Umberto Villa , Mark A. Anastasio

Transcranial photoacoustic computed tomography (PACT) is an emerging neuroimaging modality, but skull-induced aberrations can result in severe image artifacts if not compensated for during image reconstruction. The development of advanced…

Purpose: Digital phantoms are one of the key components of virtual imaging trials (VITs) that aim to assess and optimize new medical imaging systems and algorithms. However, these phantoms vary in their voxel resolution, appearance, and…

Medical Physics · Physics 2024-02-02 Amar Kavuri , Mini Das

Purpose: Optoacoustic tomography (OAT) is inherently a three-dimensional (3D) inverse problem. However, most studies of OAT image reconstruction still employ two-dimensional (2D) imaging models. One important reason is because 3D image…

Medical Physics · Physics 2013-04-09 Kun Wang , Chao Huang , Yu-Jiun Kao , Cheng-Ying Chou , Alexander A. Oraevsky , Mark A. Anastasio

Virtual Imaging Trials (VIT) offer a cost-effective and scalable approach for evaluating medical imaging technologies. Computational phantoms, which mimic real patient anatomy and physiology, play a central role in VITs. However, the…

Fluorescence molecular tomography (FMT) has potential of providing high contrast images for breast tumor detection. Computational phantom provides a convenient way to a wide variety of fluorophore distribution configurations in patients and…

Medical Physics · Physics 2018-04-02 Yansong Zhu , Abhinav K. Jha , Arman Rahmim

Photoacoustic tomography is a contrast agent-free imaging technique capable of visualizing blood vessels and tumor-associated vascularization in breast tissue. While sophisticated breast imaging systems have been recently developed, there…

Breast cancer remains the leading cause of cancer-related mortality among women worldwide, necessitating the meticulous examination of mammograms by radiologists to characterize abnormal lesions. This manual process demands high accuracy…

Image and Video Processing · Electrical Eng. & Systems 2024-11-25 Laia Domingo , Mahdi Chehimi

Optoacoustic (OA) imaging is based on excitation of biological tissues with nanosecond-duration laser pulses followed by subsequent detection of ultrasound waves generated via light-absorption-mediated thermoelastic expansion. OA imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Firat Ozdemir , Berkan Lafci , Xosé Luís Deán-Ben , Daniel Razansky , Fernando Perez-Cruz

Photoacoustic tomography (PAT) is a newly developed medical imaging modality, which combines the advantages of pure optical imaging and ultrasound imaging, owning both high optical contrast and deep penetration depth. Very recently, PAT is…

Medical Physics · Physics 2021-09-21 Tengbo Lyu , Jiadong Zhang , Zijian Gao , Changchun Yang , Feng Gao , Fei Gao

Conventional breast cancer imaging techniques are nowadays based on the use of ionising radiations or ultrasound waves for the inspection of breast areas. Nevertheless, these conventional techniques present some drawbacks related to patient…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Michele Ambrosanio , Stefano Franceschini , Vito Pascazio , Fabio Baselice

Photoacoustic computed tomography (PACT) is a hybrid imaging modality, which combines the high optical contrast of pure optical imaging and the high penetration depth of ultrasound imaging. However, photoacoustic image dataset with good…

Medical Physics · Physics 2022-05-24 Tengbo Lyu , Changchun Yang , Jiadong Zhang , Shanshan Guo , Feng Gao , Fei Gao

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is an emerging computed biomedical imaging modality that exploits optical contrast and ultrasonic detection principles. Iterative image reconstruction algorithms that…

Medical Physics · Physics 2016-11-17 Kun Wang , Robert W Schoonover , Richard Su , Alexander Oraevsky , Mark A Anastasio

Quantum imaging is emerging as a transformative approach for biomedical applications, applying nonclassical properties of light, such as entanglement, squeezing, and quantum correlations, to overcome fundamental limits of conventional…

Purpose: Photoacoustic tomography (PAT) is a novel imaging technique that can spatially resolve both morphological and functional tissue properties, such as the vessel topology and tissue oxygenation. While this capacity makes PAT a…

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to…

Medical Physics · Physics 2016-12-21 Yang Lou , Kun Wang , Alexander. A. Oraevsky , Mark. A. Anastasio

Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely…

Medical Physics · Physics 2019-12-17 Marcel Gehrung , Sarah Bohndiek , Joanna Brunker

Objective: Despite recent advancements in quantum computing, the limited number of available qubits has hindered progress in CT reconstruction. This study investigates the feasibility of utilizing quantum annealing-based computed tomography…

Quantum Physics · Physics 2024-02-12 Akihiro Haga

We present a novel approach for benchmarking and validating quantitative phase tomography (QPT) systems using three-dimensional microphantoms. These microphantoms, crafted from biological and imaging data, replicate the optical and…

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