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We present fastrerandomize, an R package for fast, scalable rerandomization in experimental design. Rerandomization improves precision by discarding treatment assignments that fail a prespecified covariate-balance criterion, but existing…

Computation · Statistics 2026-01-09 Rebecca Goldstein , Connor T. Jerzak , Aniket Kamat , Fucheng Warren Zhu

Causal analyses derived from observational data underpin high-stakes decisions in domains such as healthcare, public policy, and economics. Yet such conclusions can be surprisingly fragile: even minor data errors - duplicate records, or…

Databases · Computer Science 2025-12-18 Yarden Gabbay , Haoquan Guan , Shaull Almagor , El Kindi Rezig , Brit Youngmann , Babak Salimi

Pragmatic trials increasingly define outcomes using real-world data such as electronic health records, where assessments are collected during routine care rather than at fixed timepoints. Consequently, these uncontrolled assessments may be…

AI models are often evaluated based on their ability to predict the outcome of interest. However, in many AI for social impact applications, the presence of an intervention that affects the outcome can bias the evaluation. Randomized…

Machine Learning · Computer Science 2025-11-18 Winston Chen , Michael W. Sjoding , Jenna Wiens

Randomized benchmarking is a powerful technique to efficiently estimate the performance and reliability of quantum gates, circuits and devices. Here we propose to perform randomized benchmarking in a coherent way, where superpositions of…

Quantum Physics · Physics 2021-07-14 Jorge Miguel-Ramiro , Alexander Pirker , Wolfgang Dür

A benefit of randomized experiments is that covariate distributions of treatment and control groups are balanced on average, resulting in simple unbiased estimators for treatment effects. However, it is possible that a particular…

Methodology · Statistics 2019-02-01 Zach Branson , Luke Miratrix

Randomized controlled trials are not only the golden standard in medicine and vaccine trials but have spread to many other disciplines like behavioral economics, making it an important interdisciplinary tool for scientists. When designing…

Methodology · Statistics 2021-11-30 Tassilo Schwarz

Hybrid controlled trials (HCTs), which augment randomized controlled trials (RCTs) with external controls (ECs), are increasingly receiving attention as a way to address limited power, slow accrual, and ethical concerns in clinical…

Methodology · Statistics 2025-05-02 Jiajun Liu , Ke Zhu , Shu Yang , Xiaofei Wang

Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of…

Methodology · Statistics 2026-01-22 Xinyuan Chen , Fan Li

Missed and delayed diagnosis remains a major challenge in rare disease care. At the initial clinical encounters, physicians assess rare disease risk using only limited information under high uncertainty. When high-risk patients are not…

Artificial Intelligence · Computer Science 2026-01-27 Xi Chen , Hongru Zhou , Huahui Yi , Shiyu Feng , Hanyu Zhou , Tiancheng He , Mingke You , Li Wang , Qiankun Li , Kun Wang , Weili Fu , Kang Li , Jian Li

Randomized trials are viewed as the benchmark for assessing causal effects of treatments on outcomes of interest. Nonetheless, challenges such as measurement error can undermine the standard causal assumptions for randomized trials. In…

Methodology · Statistics 2025-08-27 Dane Isenberg , Nandita Mitra , Steven C. Marcus , Rinad S. Beidas , Kristin A. Linn

There are multiple cluster randomised trial designs that vary in when the clusters cross between control and intervention states, when observations are made within clusters, and how many observations are made at that time point. Identifying…

Methodology · Statistics 2023-07-20 Samuel I. Watson , Alan Girling , Karla Hemming

In its many variants, randomized benchmarking (RB) is a broadly used technique for assessing the quality of gate implementations on quantum computers. A detailed theoretical understanding and general guarantees exist for the functioning and…

Quantum Physics · Physics 2023-06-28 Markus Heinrich , Martin Kliesch , Ingo Roth

Parametric analysis is a powerful tool for designing modern embedded systems, because it permits to explore the space of design parameters, and to check the robustness of the system with respect to variations of some uncontrollable…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-02-07 Youcheng Sun , Romain Soulat , Giuseppe Lipari , Étienne André , Laurent Fribourg

Randomized controlled trials (RCTs) are the gold standard for evaluating the causal effect of a treatment; however, they often have limited sample sizes and sometimes poor generalizability. On the other hand, non-randomized, observational…

Methodology · Statistics 2021-09-23 Shuxiao Chen , Bo Zhang , Ting Ye

Randomized benchmarking is a useful scheme for evaluation the average fidelity of a noisy quantum circuit. However, it is insensitive to the unitary error. Here, we propose a method of randomized benchmarking in which a unitary t-design is…

Quantum Physics · Physics 2017-12-13 Linxi Zhang , Chuanghua Zhu , Changxing Pei

Randomized controlled trials are susceptible to imbalance on covariates predictive of the outcome. Rerandomization and deterministic treatment assignment are two proposed solutions. This paper explores the relationship between…

Methodology · Statistics 2023-10-03 Connor T. Jerzak , Rebecca Goldstein

Randomized controlled trials (RCT's) allow researchers to estimate causal effects in an experimental sample with minimal identifying assumptions. However, to generalize or transport a causal effect from an RCT to a target population,…

Methodology · Statistics 2022-02-08 Melody Huang

Randomized Controlled Trials (RCTs) are often considered the gold standard for estimating causal effect, but they may lack external validity when the population eligible to the RCT is substantially different from the target population.…

Methodology · Statistics 2023-01-11 Bénédicte Colnet , Julie Josse , Erwan Scornet , Gaël Varoquaux

Indirect experiments provide a valuable framework for estimating treatment effects in situations where conducting randomized control trials (RCTs) is impractical or unethical. Unlike RCTs, indirect experiments estimate treatment effects by…

Machine Learning · Computer Science 2023-12-06 Yash Chandak , Shiv Shankar , Vasilis Syrgkanis , Emma Brunskill