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We take up the challenge of designing realistic computational models of large interacting cell populations. The goal is essentially to bring Gillespie's celebrated stochastic methodology to the level of an interacting population of cells.…

Computational Engineering, Finance, and Science · Computer Science 2018-10-26 Stefan Engblom

Neural circuits are able to perform computations under very diverse conditions and requirements. The required computations impose clear constraints on their fine-tuning: a rapid and maximally informative response to stimuli in general…

Neurons and Cognition · Quantitative Biology 2019-10-22 Jens Wilting , Jonas Dehning , Joao Pinheiro Neto , Lucas Rudelt , Michael Wibral , Johannes Zierenberg , Viola Priesemann

Serotonergic, noradrenergic and dopaminergic brainstem (including midbrain) neurons, often exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz, though dopaminergic and noradrenergic neurons only exhibit such…

Neurons and Cognition · Quantitative Biology 2017-04-18 Henry C. Tuckwell , Ying Zhou , Nicholas J. Penington

Information coding by precise timing of spikes can be faster and more energy-efficient than traditional rate coding. However, spike-timing codes are often brittle, which has limited their use in theoretical neuroscience and computing…

Neural and Evolutionary Computing · Computer Science 2019-01-24 E. Paxon Frady , Friedrich T. Sommer

With the goal of building a model of the HVC nucleus in the avian song system, we discuss in detail a model of HVC$_{\text{RA}}$ projection neurons comprised of a somatic compartment with fast Na$^+$ and K$^+$ currents and a dendritic…

Neurons and Cognition · Quantitative Biology 2016-09-30 Nirag Kadakia , Eve Armstrong , Daniel Breen , Uriel Morone , Arij Daou , Daniel Margoliash , Henry DI Abarbanel

Environmental signals sensed by nervous systems are often represented in spike trains carried from sensory neurons to higher neural functions where decisions and functional actions occur. Information about the environmental stimulus is…

Biological Physics · Physics 2007-05-23 Henry D. I. Abarbanel , Evren C. Tumer

Integrating and processing information from various sources or modalities are critical for obtaining a comprehensive and accurate perception of the real world. Drawing inspiration from neuroscience, we develop the Information-Theoretic…

Machine Learning · Computer Science 2024-04-24 Xiongye Xiao , Gengshuo Liu , Gaurav Gupta , Defu Cao , Shixuan Li , Yaxing Li , Tianqing Fang , Mingxi Cheng , Paul Bogdan

An electronic circuit device, inspired on the FitzHugh-Nagumo model of neuronal excitability, was constructed and shown to operate with characteristics compatible with those of biological sensory neurons. The nonlinear dynamical model of…

In recent years, Spiking Neural Networks (SNNs) have gathered significant interest due to their temporal understanding capabilities. This work introduces, to the best of our knowledge, the first Cortical Column like hybrid architecture for…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Aaron Bateni

In this work, a spiking neural network (SNN) is proposed for approximating differential sensorimotor maps of robotic systems. The computed model is used as a local Jacobian-like projection that relates changes in sensor space to changes in…

Robotics · Computer Science 2021-10-12 Omar Zahra , Silvia Tolu , David Navarro-Alarcon

We consider a new class of non Markovian processes with a countable number of interacting components, both in discrete and continuous time. Each component is represented by a point process indicating if it has a spike or not at a given…

Neurons and Cognition · Quantitative Biology 2015-02-24 A. Galves , E. Löcherbach

Living systems continuously sense, integrate, and act on chemical information using multiscale biochemical networks whose dynamics are inherently nonlinear, adaptive, and energy-efficient. Yet, most attempts to harness such "wetware" for…

Emerging Technologies · Computer Science 2026-02-03 Ceylin Savas , Maryam Javed , Murat Kuscu

Modeling brain dynamics to better understand and control complex behaviors underlying various cognitive brain functions are of interests to engineers, mathematicians, and physicists from the last several decades. With a motivation of…

Neurons and Cognition · Quantitative Biology 2019-08-21 Benjamin Plaster , Gautam Kumar

Our knowledge of the sensory world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant…

Neurons and Cognition · Quantitative Biology 2007-05-23 Ilya Nemenman , Geoffrey D. Lewen , William Bialek , Rob R. de Ruyter van Steveninck

A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a…

Biological Physics · Physics 2007-05-23 Roberto Chignola , Edoardo Milotti

Spiking Neural Networks (SNNs) offer a biologically plausible and energy-efficient framework for temporal information processing. However, existing studies overlook a fundamental property widely observed in biological neurons-synaptic…

Neurons and Cognition · Quantitative Biology 2025-08-19 Zhichao Deng , Zhikun Liu , Junxue Wang , Shengqian Chen , Xiang Wei , Qiang Yu

To understand possible strategies of temporal spike coding in the central nervous system, we study functional neuromimetic models of visual processing for static images. We will first present the retinal model which was introduced by Van…

Neurons and Cognition · Quantitative Biology 2007-05-23 Laurent Perrinet , Manuel Samuelides , Simon Thorpe

The final version of this paper has been published in IEEEXplore available at http://ieeexplore.ieee.org/document/7727213. Please cite this paper as: Amirhossein Tavanaei, Timothee Masquelier, and Anthony Maida, Acquisition of visual…

Neural and Evolutionary Computing · Computer Science 2016-11-10 Amirhossein Tavanaei , Timothee Masquelier , Anthony S Maida

Neurostimulation technologies have seen a recent surge in interest from the neuroscience and controls communities alike due to their proven potential to treat conditions such as Parkinson's Disease, and depression. The provided stimulation…

Systems and Control · Electrical Eng. & Systems 2023-01-03 Gagan Acharya , Sebastian F. Ruf , Erfan Nozari

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…

Molecular Networks · Quantitative Biology 2017-04-12 Thomas E. Ouldridge , Christopher C. Govern , Pieter Rein ten Wolde