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Data-driven decision making frequently relies on predicting counterfactual outcomes. In practice, researchers commonly train counterfactual prediction models on a source dataset to inform decisions on a possibly separate target population.…

Machine Learning · Statistics 2026-04-07 Keith Barnatchez , Kevin P. Josey , Rachel C. Nethery , Giovanni Parmigiani

Conditional Average Treatment Effects (CATE) estimation is one of the main challenges in causal inference with observational data. In addition to Machine Learning based-models, nonparametric estimators called meta-learners have been…

Machine Learning · Statistics 2023-06-06 Naoufal Acharki , Ramiro Lugo , Antoine Bertoncello , Josselin Garnier

Artificial intelligence (AI) is moving increasingly beyond prediction to support decisions in complex, uncertain, and dynamic environments. This shift creates a natural intersection with operations research and management sciences (OR/MS),…

Optimization and Control · Mathematics 2026-04-14 I. Esra Buyuktahtakin

Estimating the conditional average treatment effect (CATE) from observational data is relevant for many applications such as personalized medicine. Here, we focus on the widespread setting where the observational data come from multiple…

Machine Learning · Computer Science 2024-06-05 Jonas Schweisthal , Dennis Frauen , Mihaela van der Schaar , Stefan Feuerriegel

Risk-averse total-reward Markov Decision Processes (MDPs) offer a promising framework for modeling and solving undiscounted infinite-horizon objectives. Existing model-based algorithms for risk measures like the entropic risk measure (ERM)…

Machine Learning · Computer Science 2025-10-27 Xihong Su , Jia Lin Hau , Gersi Doko , Kishan Panaganti , Marek Petrik

Sequential recommenders have made great strides in capturing a user's preferences. Nevertheless, the cold-start recommendation remains a fundamental challenge as they typically involve limited user-item interactions for personalization.…

Information Retrieval · Computer Science 2023-08-22 Minchang Kim , Yongjin Yang , Jung Hyun Ryu , Taesup Kim

Recent work has shown a variety of ways in which machine learning can be used to accelerate the solution of constrained optimization problems. Increasing demand for real-time decision-making capabilities in applications such as artificial…

Machine Learning · Computer Science 2024-04-02 Ethan King , James Kotary , Ferdinando Fioretto , Jan Drgona

Reinforcement Learning (RL) has achieved tremendous success in recent years. However, the classical foundations of RL do not account for the risk sensitivity of the objective function, which is critical in various fields, including…

Machine Learning · Computer Science 2025-11-14 Mohammad Alipour-Vaezi , Huaiyang Zhong , Kwok-Leung Tsui , Sajad Khodadadian

Decision-focused learning is a promising development for contextual optimisation. It enables us to train prediction models that reflect the contextual sensitivity structure of the problem. However, there have been limited attempts to extend…

Optimization and Control · Mathematics 2023-12-21 Egon Peršak , Miguel F. Anjos

A fundamental feature of human intelligence is the ability to infer high-level abstractions from low-level sensory data. An essential component of such inference is the ability to discover modularized generative mechanisms. Despite many…

Machine Learning · Computer Science 2023-06-08 Peyman Sheikholharam Mashhadi , Slawomir Nowaczyk

Distractors-incorrect yet plausible answer choices in multiple-choice questions (MCQs)-are vital in educational assessments, as they help identify student misconceptions by presenting potential reasoning errors. Current distractor…

Computation and Language · Computer Science 2026-04-21 Tao Wu , Jingyuan Chen , Wang Lin , Jian Zhan , Mengze Li , Fangzhou Jin , Min Zhang , Kun Kuang , Fei Wu

Estimating heterogeneous treatment effects (HTEs) is crucial for precision medicine. While multiple studies can improve the generalizability of results, leveraging them for estimation is statistically challenging. Existing approaches often…

Methodology · Statistics 2025-12-22 Cathy Shyr , Boyu Ren , Prasad Patil , Giovanni Parmigiani

The framework of decision-making, modeled as a Markov Decision Process (MDP), typically assumes a single objective. However, practical scenarios often involve tradeoffs between multiple objectives. We address this in the Linear Quadratic…

Optimization and Control · Mathematics 2025-01-16 Ali Jadbabaie , Devavrat Shah , Sean R. Sinclair

Long-form chain-of-thought reasoning has become a cornerstone of advanced reasoning in large language models. While recent verification-refinement frameworks have enabled proprietary models to solve Olympiad-level problems, their…

Computation and Language · Computer Science 2025-10-21 Zihan Liu , Shun Zheng , Xumeng Wen , Yang Wang , Jiang Bian , Mao Yang

Deep Q-Learning is an important reinforcement learning algorithm, which involves training a deep neural network, called Deep Q-Network (DQN), to approximate the well-known Q-function. Although wildly successful under laboratory conditions,…

Machine Learning · Computer Science 2021-04-13 Arunselvan Ramaswamy , Eyke Hüllermeier

The longitudinal analysis of patient response time course following doses of therapeutics is currently performed using Pharmacokinetic/Pharmacodynamic (PK/PD) methodologies, which requires significant human experience and expertise in the…

Machine Learning · Computer Science 2021-06-24 James Lu , Brendan Bender , Jin Y. Jin , Yuanfang Guan

Machine learning has shown much promise in helping improve the quality of medical, legal, and financial decision-making. In these applications, machine learning models must satisfy two important criteria: (i) they must be causal, since the…

Machine Learning · Computer Science 2021-10-12 Carolyn Kim , Osbert Bastani

This paper introduces Meta-Q-Learning (MQL), a new off-policy algorithm for meta-Reinforcement Learning (meta-RL). MQL builds upon three simple ideas. First, we show that Q-learning is competitive with state-of-the-art meta-RL algorithms if…

Machine Learning · Computer Science 2020-04-07 Rasool Fakoor , Pratik Chaudhari , Stefano Soatto , Alexander J. Smola

Randomized trials are typically designed to detect average treatment effects but often lack the statistical power to uncover individual-level treatment effect heterogeneity, limiting their value for personalized decision-making. To address…

Machine Learning · Statistics 2026-03-19 Rickard Karlsson , Piersilvio De Bartolomeis , Issa J. Dahabreh , Jesse H. Krijthe

Multi-view stacking is a framework for combining information from different views (i.e. different feature sets) describing the same set of objects. In this framework, a base-learner algorithm is trained on each view separately, and their…

Machine Learning · Statistics 2024-04-16 Wouter van Loon , Marjolein Fokkema , Botond Szabo , Mark de Rooij