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Free energy landscapes encode the kinetics, intermediates, and transition states that govern molecular processes and are thus a key target of single biomolecule research. Typical approaches to deriving optimal, error-minimizing,…

Biological Physics · Physics 2025-11-25 Oliver Cheng , Zosia Adamska , Michael P. Brenner , Megan C. Engel

Understanding quantum phase transitions in physical systems is fundamental to characterize their behavior at low temperatures. Achieving this requires both accessing good approximations to the ground state and identifying order parameters…

Quantum Physics · Physics 2025-06-06 Chenfeng Cao , Filippo Maria Gambetta , Ashley Montanaro , Raul A. Santos

State-space models (SSM) are central to describe time-varying complex systems in countless signal processing applications such as remote sensing, networks, biomedicine, and finance to name a few. Inference and prediction in SSMs are…

Computation · Statistics 2022-10-26 Víctor Elvira , Émilie Chouzenoux

We present a Bayesian approach to identify optimal transformations that map model input points to low dimensional latent variables. The "projection" mapping consists of an orthonormal matrix that is considered a priori unknown and needs to…

Machine Learning · Statistics 2021-09-22 Panagiotis Tsilifis , Piyush Pandita , Sayan Ghosh , Valeria Andreoli , Thomas Vandeputte , Liping Wang

A method for locating first order saddle points on the energy surface of a magnetic system is described and several applications presented where the mechanism of various magnetic transitions is identified. The starting point for the…

Computational Physics · Physics 2025-01-17 Hendrik Schrautzer , Moritz Sallermann , Pavel F. Bessarab , Hannes Jónsson

In this paper we first identify a basic limitation in gradient descent-based optimization methods when used in conjunctions with smooth kernels. An analysis based on the spectral properties of the kernel demonstrates that only a vanishingly…

Machine Learning · Statistics 2017-06-20 Siyuan Ma , Mikhail Belkin

Optimizing k-space sampling trajectories is a promising yet challenging topic for fast magnetic resonance imaging (MRI). This work proposes to optimize a reconstruction method and sampling trajectories jointly concerning image…

Signal Processing · Electrical Eng. & Systems 2022-04-15 Guanhua Wang , Tianrui Luo , Jon-Fredrik Nielsen , Douglas C. Noll , Jeffrey A. Fessler

A feature-mapping framework for inverse reconstruction of density-based topology optimization results is proposed. Unlike SIMP, whose voxelized outputs are hard to interpret or reuse, the method represents designs with high-level geometric…

Optimization and Control · Mathematics 2026-02-16 Patrick Jung

To maximize the economic benefits of geothermal energy production, it is essential to optimize geothermal reservoir management strategies, in which geologic uncertainty should be considered. In this work, we propose a closed-loop…

Machine Learning · Computer Science 2022-04-20 Nanzhe Wang , Haibin Chang , Xiangzhao Kong , Martin O. Saar , Dongxiao Zhang

We introduce a simultaneous and meshfree topology optimization (TO) framework based on physics-informed Gaussian processes (GPs). Our framework endows all design and state variables via GP priors which have a shared, multi-output mean…

Machine Learning · Computer Science 2025-03-21 Amin Yousefpour , Shirin Hosseinmardi , Xiangyu Sun , Ramin Bostanabad

We implemented a gradient-based algorithm for transition state search which uses Gaussian process regression. Besides a description of the algorithm, we provide a method to find the starting point for the optimization if only the reactant…

Chemical Physics · Physics 2020-09-15 Alexander Denzel , Johannes Kästner

Accurate learning of system dynamics is becoming increasingly crucial for advanced control and decision-making in engineering. However, real-world systems often exhibit multiple channels and highly nonlinear transition dynamics, challenging…

Machine Learning · Statistics 2025-10-20 Tengjie Zheng , Jilan Mei , Di Wu , Lin Cheng , Shengping Gong

Neural network quantum states are a promising tool to analyze complex quantum systems given their representative power. It can however be difficult to optimize efficiently and effectively the parameters of this type of ansatz. Here we…

Quantum Physics · Physics 2023-05-10 Wenxuan Zhang , Xiansong Xu , Zheyu Wu , Vinitha Balachandran , Dario Poletti

Associative memory Hamiltonian structure prediction potentials are not overly rugged, thereby suggesting their landscapes are like those of actual proteins. In the present contribution we show how basin-hopping global optimization can…

Biomolecules · Quantitative Biology 2009-11-13 Michael C. Prentiss , David J. Wales , Peter G. Wolynes

Determining the ground state of a many-body Hamiltonian is a central problem across physics, chemistry, and combinatorial optimization, yet it is often classically intractable due to the exponential growth of Hilbert space with system size.…

Quantum Physics · Physics 2026-02-24 Jungyun Lee , Daniel K. Park

This paper introduces a convex optimization framework for identifying switched network systems, in which both the node dynamics and the underlying graph topology switch between a finite number of configurations. Building on our recent…

Optimization and Control · Mathematics 2025-10-29 Kaito Iwasaki , Anthony Bloch , Maani Ghaffari

In this investigation, we propose several algorithms to recover the location and intensity of a radiation source located in a simulated 250 m x 180 m block in an urban center based on synthetic measurements. Radioactive decay and detection…

Applications · Statistics 2016-07-05 Razvan Stefanescu , Kathleen Schmidt , Jason Hite , Ralph Smith , John Mattingly

Simulation of surface processes is a key part of computational chemistry that offers atomic-scale insights into mechanisms of heterogeneous catalysis, diffusion dynamics, as well as quantum tunneling phenomena. The most common theoretical…

Chemical Physics · Physics 2023-05-01 Wei Fang , Yu-Cheng Zhu , Yi-Han Cheng , Yi-Ping Hao , Jeremy O. Richardson

This study presents a computational framework for global local structural analysis of ship hull girders that integrates an equivalent single layer (ESL) model with a graph neural network (GNN). A coarse mesh homogenized ESL model…

Computational Engineering, Finance, and Science · Computer Science 2025-12-24 Yuecheng Cai , Jasmin Jelovica

We study the non-convex optimization landscape for maximum likelihood estimation in the discrete orbit recovery model with Gaussian noise. This model is motivated by applications in molecular microscopy and image processing, where each…

Statistics Theory · Mathematics 2021-03-02 Zhou Fan , Yi Sun , Tianhao Wang , Yihong Wu