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Motivation. Cancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches to link organ- and tissue-level information from diagnostic images and…

Quantitative Methods · Quantitative Biology 2020-05-19 Nova F. Smedley , Suzie El-Saden , William Hsu

Network biology has been successfully used to help reveal complex mechanisms of disease, especially cancer. On the other hand, network biology requires in-depth knowledge to construct disease-specific networks, but our current knowledge is…

Computer Vision and Pattern Recognition · Computer Science 2018-06-18 Sungmin Rhee , Seokjun Seo , Sun Kim

Concept-based interpretability for Convolutional Neural Networks (CNNs) aims to align internal model representations with high-level semantic concepts, but existing approaches largely overlook the semantic roles of individual filters and…

Machine Learning · Computer Science 2025-09-24 Xinyu Mu , Hui Dou , Furao Shen , Jian Zhao

Fetal standard scan plane detection during 2-D mid-pregnancy examinations is a highly complex task, which requires extensive medical knowledge and years of training. Although deep neural networks (DNN) can assist inexperienced operators in…

Machine Learning · Computer Science 2026-03-09 Yingni Wanga , Yunxiao Liua , Licong Dongc , Xuzhou Wua , Huabin Zhangb , Qiongyu Yed , Desheng Sunc , Xiaobo Zhoue , Kehong Yuan

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

Genomics · Quantitative Biology 2019-06-04 Tianle Ma , Aidong Zhang

There is an increasing interest in the use of Deep Learning (DL) based methods as a supporting analytical framework in oncology. However, most direct applications of DL will deliver models with limited transparency and explainability, which…

Quantitative Methods · Quantitative Biology 2023-01-26 Magdalena Wysocka , Oskar Wysocki , Marie Zufferey , Dónal Landers , André Freitas

Whole slide image (WSI) analysis is gaining prominence within the medical imaging field. Recent advances in pathology foundation models have shown the potential to extract powerful feature representations from WSIs for downstream tasks.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-18 Yanyan Huang , Weiqin Zhao , Yihang Chen , Yu Fu , Lequan Yu

Early detection is crucial for successful cancer treatment and increasing survivability rates, particularly in the most common forms. Ten different cancers have been identified in most of these advances that effectively use CNNs…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Hossein Molaeian , Kaveh Karamjani , Sina Teimouri , Saeed Roshani , Sobhan Roshani

Ultrasound images are one of the most widely used techniques in clinical settings to analyze and detect different organs for study or diagnoses of diseases. The dependence on subjective opinions of experts such as radiologists calls for an…

Image and Video Processing · Electrical Eng. & Systems 2019-11-25 Ruturaj Gole , Haixia Wu , Subho Ghose

In this work we propose Pathfinder Discovery Networks (PDNs), a method for jointly learning a message passing graph over a multiplex network with a downstream semi-supervised model. PDNs inductively learn an aggregated weight for each edge,…

Machine Learning · Computer Science 2021-02-18 Benedek Rozemberczki , Peter Englert , Amol Kapoor , Martin Blais , Bryan Perozzi

Understanding the spatial architecture of the tumor microenvironment (TME) is critical to advance precision oncology. We present ProteinPNet, a novel framework based on prototypical part networks that discovers TME motifs from spatial…

Machine Learning · Computer Science 2025-12-03 Louis McConnell , Jieran Sun , Theo Maffei , Raphael Gottardo , Marianna Rapsomaniki

Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of…

Image and Video Processing · Electrical Eng. & Systems 2021-04-14 Adalberto Claudio Quiros , Roderick Murray-Smith , Ke Yuan

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

In this paper, we examine the strength of deep learning technique for diagnosing lung cancer on medical image analysis problem. Convolutional neural networks (CNNs) models become popular among the pattern recognition and computer vision…

Computer Vision and Pattern Recognition · Computer Science 2018-04-24 Mehdi Fatan Serj , Bahram Lavi , Gabriela Hoff , Domenec Puig Valls

The advancement of computer-aided detection systems had a significant impact on clinical analysis and decision-making on human disease. Lung cancer requires more attention among the numerous diseases being examined because it affects both…

Image and Video Processing · Electrical Eng. & Systems 2023-05-24 Jafar Abdollahi

Foundation models are widely employed in medical image analysis, due to their high adaptability and generalizability for downstream tasks. With the increasing number of foundation models being released, model selection has become an…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Fuping Wu , Bartlomiej W. Papiez

Recent breakthroughs in self-supervised learning have enabled the use of large unlabeled datasets to train visual foundation models that can generalize to a variety of downstream tasks. While this training paradigm is well suited for the…

Ontological commitment, i.e., used concepts, relations, and assumptions, are a corner stone of qualitative reasoning (QR) models. The state-of-the-art for processing raw inputs, though, are deep neural networks (DNNs), nowadays often based…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Mert Keser , Gesina Schwalbe , Niki Amini-Naieni , Matthias Rottmann , Alois Knoll

Deep learning shows promise for medical image analysis but lacks interpretability, hindering adoption in healthcare. Attribution techniques that explain model reasoning may increase trust in deep learning among clinical stakeholders. This…

Machine Learning · Computer Science 2023-08-08 Yusuf Brima , Marcellin Atemkeng

Three-dimensional (3D) kidney parsing on computed tomography angiography (CTA) images is of great clinical significance. Automatic segmentation of kidney, renal tumor, renal vein and renal artery benefits a lot on surgery-based renal cancer…

Image and Video Processing · Electrical Eng. & Systems 2022-07-20 Yusheng Liu , Zhongchen Zhao , Lisheng Wang