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Messenger RNA (mRNA) plays a crucial role in protein synthesis, with its codon structure directly impacting biological properties. While Language Models (LMs) have shown promise in analyzing biological sequences, existing approaches fail to…

Machine Learning · Computer Science 2025-03-13 Mehdi Yazdani-Jahromi , Mangal Prakash , Tommaso Mansi , Artem Moskalev , Rui Liao

Large language models (LLMs) have shown great success in text modeling tasks across domains. However, natural language exhibits inherent semantic hierarchies and nuanced geometric structure, which current LLMs do not capture completely…

Machine Learning · Computer Science 2025-11-07 Neil He , Rishabh Anand , Hiren Madhu , Ali Maatouk , Smita Krishnaswamy , Leandros Tassiulas , Menglin Yang , Rex Ying

Large language models (LLMs) have achieved remarkable success and demonstrated superior performance across various tasks, including natural language processing (NLP), weather forecasting, biological protein folding, text generation, and…

Artificial Intelligence · Computer Science 2025-12-09 Sarang Patil , Zeyong Zhang , Yiran Huang , Tengfei Ma , Mengjia Xu

Large Language Models (LLMs) have attracted significant attention in recommender systems for their excellent world knowledge capabilities. However, existing methods that rely on Euclidean space struggle to capture the rich hierarchical…

Information Retrieval · Computer Science 2025-04-22 Wentao Cheng , Zhida Qin , Zexue Wu , Pengzhan Zhou , Tianyu Huang

Natural language text exhibits hierarchical structure in a variety of respects. Ideally, we could incorporate our prior knowledge of this hierarchical structure into unsupervised learning algorithms that work on text data. Recent work by…

Computation and Language · Computer Science 2018-06-13 Bhuwan Dhingra , Christopher J. Shallue , Mohammad Norouzi , Andrew M. Dai , George E. Dahl

Hyperbolic geometry is an effective geometry for embedding hierarchical data structures. Hyperbolic learning has therefore become increasingly prominent in machine learning applications where data is hierarchically organized or governed by…

Artificial Intelligence · Computer Science 2025-11-27 Melika Ayoughi , Pascal Mettes , Paul Groth

Retrieval-augmented generation (RAG) for biomedical knowledge faces a hierarchy-aware ontology grounding challenge: resources like HPO, DO, and MeSH use deep ``is-a" taxonomies, yet production stacks rely on Euclidean embeddings and ANN…

Information Retrieval · Computer Science 2026-04-14 Ou Deng , Shoji Nishimura , Atsushi Ogihara , Qun Jin

Understanding the intricate mappings between visual stimuli and neural responses is a fundamental challenge in cognitive neuroscience. While current approaches predominantly align images and functional magnetic resonance imaging (fMRI)…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Zihan Ma , Tian Xia , Kexin Wang , Xiao Li , Xiaowei He , Yudan Ren

Selective state-space models excel at long-sequence modeling, but their capacity for language representation -- in complex hierarchical reasoning -- remains underexplored. Most large language models rely on \textit{flat} Euclidean…

Computation and Language · Computer Science 2025-12-08 Sarang Patil , Ashish Parmanand Pandey , Ioannis Koutis , Mengjia Xu

This paper focuses on the problem of unsupervised alignment of hierarchical data such as ontologies or lexical databases. This is a problem that appears across areas, from natural language processing to bioinformatics, and is typically…

Machine Learning · Computer Science 2020-05-11 David Alvarez-Melis , Youssef Mroueh , Tommi S. Jaakkola

Taxonomic classification in biodiversity research involves organizing biological specimens into structured hierarchies based on evidence, which can come from multiple modalities such as images and genetic information. We investigate whether…

Foundation models pre-trained on massive datasets, including large language models (LLMs), vision-language models (VLMs), and large multimodal models, have demonstrated remarkable success in diverse downstream tasks. However, recent studies…

Machine Learning · Computer Science 2025-07-25 Neil He , Hiren Madhu , Ngoc Bui , Menglin Yang , Rex Ying

Current approaches to genomic sequence modeling often struggle to align the inductive biases of machine learning models with the evolutionarily-informed structure of biological systems. To this end, we formulate a novel application of…

Machine Learning · Computer Science 2025-07-30 Raiyan R. Khan , Philippe Chlenski , Itsik Pe'er

Various neuroimaging studies suffer from small sample size problem which often limit their reliability. Meta-analysis addresses this challenge by aggregating findings from different studies to identify consistent patterns of brain activity.…

Machine Learning · Computer Science 2025-11-27 Seunghun Baek , Jaejin Lee , Jaeyoon Sim , Minjae Jeong , Won Hwa Kim

Label inventories for fine-grained entity typing have grown in size and complexity. Nonetheless, they exhibit a hierarchical structure. Hyperbolic spaces offer a mathematically appealing approach for learning hierarchical representations of…

Computation and Language · Computer Science 2020-10-06 Federico López , Michael Strube

This paper investigates the notion of learning user and item representations in non-Euclidean space. Specifically, we study the connection between metric learning in hyperbolic space and collaborative filtering by exploring Mobius…

Information Retrieval · Computer Science 2019-12-02 Lucas Vinh Tran , Yi Tay , Shuai Zhang , Gao Cong , Xiaoli Li

Genomic sequence analysis plays a crucial role in various scientific and medical domains. Traditional machine-learning approaches often struggle to capture the complex relationships and hierarchical structures of sequence data when working…

Machine Learning · Computer Science 2025-10-02 Sarwan Ali , Haris Mansoor , Murray Patterson

Different from the traditional classification tasks which assume mutual exclusion of labels, hierarchical multi-label classification (HMLC) aims to assign multiple labels to every instance with the labels organized under hierarchical…

Machine Learning · Computer Science 2019-09-05 Boli Chen , Xin Huang , Lin Xiao , Zixin Cai , Liping Jing

Artificial intelligence (AI) is reshaping computational and network biology by enabling new approaches to decode cellular communication networks. We introduce Hierarchical Molecular Language Models (HMLMs), a novel framework that models…

Molecular Networks · Quantitative Biology 2025-12-16 Hasi Hays , Yue Yu , William J. Richardson

Interpreting hierarchical structures latent in language is a key limitation of current language models (LMs). While previous research has implicitly leveraged these hierarchies to enhance LMs, approaches for their explicit encoding are yet…

Computation and Language · Computer Science 2024-11-22 Yuan He , Zhangdie Yuan , Jiaoyan Chen , Ian Horrocks
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