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For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Multi-label classification (MLC) is the task of assigning a set of target labels for a given sample. Modeling the combinatorial label interactions in MLC has been a long-haul challenge. We propose Label Message Passing (LaMP) Neural…

Machine Learning · Computer Science 2019-04-18 Jack Lanchantin , Arshdeep Sekhon , Yanjun Qi

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

In multi-label classification, each training instance is associated with multiple class labels simultaneously. Unfortunately, collecting the fully precise class labels for each training instance is time- and labor-consuming for real-world…

Machine Learning · Computer Science 2024-03-26 Meng Wei , Zhongnian Li , Peng Ying , Yong Zhou , Xinzheng Xu

Attention-based deep networks have been successfully applied on textual data in the field of NLP. However, their application on protein sequences poses additional challenges due to the weak semantics of the protein words, unlike the plain…

Machine Learning · Computer Science 2022-08-29 Ashish Ranjan , Md Shah Fahad , Akshay Deepak

DNA-binding proteins (DBPs) are integral to gene regulation and cellular processes, making their accurate identification essential for understanding biological functions and disease mechanisms. Experimental methods for DBP identification…

Machine Learning · Computer Science 2025-07-29 Samiul Based Shuvo , Tasnia Binte Mamun , U Rajendra Acharya

Recent years have witnessed increasing interests in prompt-based learning in which models can be trained on only a few annotated instances, making them suitable in low-resource settings. When using prompt-based learning for text…

Computation and Language · Computer Science 2023-05-11 Hongjing Li , Hanqi Yan , Yanran Li , Li Qian , Yulan He , Lin Gui

Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…

Machine Learning · Computer Science 2026-02-23 Yujia Wang , Jihong Guan , Wengen Li , Shuigeng Zhou , Xuhong Wang

Bridging the exponentially growing gap between the numbers of unlabeled and labeled protein sequences, several studies adopted semi-supervised learning for protein sequence modeling. In these studies, models were pre-trained with a…

Biomolecules · Quantitative Biology 2021-09-20 Seonwoo Min , Seunghyun Park , Siwon Kim , Hyun-Soo Choi , Byunghan Lee , Sungroh Yoon

This paper addresses the challenges posed by the unstructured nature and high-dimensional semantic complexity of electronic health record texts. A deep learning method based on attention mechanisms is proposed to achieve unified modeling…

Computation and Language · Computer Science 2025-07-03 Ting Xu , Xiaoxiao Deng , Xiandong Meng , Haifeng Yang , Yan Wu

Recently, prompt-based learning has gained popularity across many natural language processing (NLP) tasks by reformulating them into a cloze-style format to better align pre-trained language models (PLMs) with downstream tasks. However,…

Computation and Language · Computer Science 2023-08-15 Wenjie Zhang , Xiaoning Song , Zhenhua Feng , Tianyang Xu , Xiaojun Wu

With the success of pre-trained visual-language (VL) models such as CLIP in visual representation tasks, transferring pre-trained models to downstream tasks has become a crucial paradigm. Recently, the prompt tuning paradigm, which draws…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Jingsheng Gao , Jiacheng Ruan , Suncheng Xiang , Zefang Yu , Ke Ji , Mingye Xie , Ting Liu , Yuzhuo Fu

Recently, prompt tuning \cite{lester2021power} has gradually become a new paradigm for NLP, which only depends on the representation of the words by freezing the parameters of pre-trained language models (PLMs) to obtain remarkable…

Computation and Language · Computer Science 2022-01-31 Pan He , Yuxi Chen , Yan Wang , Yanru Zhang

Recently, large-scale visual language pre-trained (VLP) models have demonstrated impressive performance across various downstream tasks. Motivated by these advancements, pioneering efforts have emerged in multi-label image recognition with…

Computer Vision and Pattern Recognition · Computer Science 2024-08-30 Leilei Ma , Hongxing Xie , Lei Wang , Yanping Fu , Dengdi Sun , Haifeng Zhao

The identification of DNA-binding proteins (DBPs) is essential due to their significant impact on various biological activities. Understanding the mechanisms underlying protein-DNA interactions is essential for elucidating various life…

Machine Learning · Computer Science 2026-01-27 A. Quadir , M. Sajid , M. Tanveer

Multi-label recognition with partial labels (MLR-PL), in which only some labels are known while others are unknown for each image, is a practical task in computer vision, since collecting large-scale and complete multi-label datasets is…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Haoxian Ruan , Zhihua Xu , Zhijing Yang , Yongyi Lu , Jinghui Qin , Tianshui Chen

Deciphering protein function remains a fundamental challenge in protein representation learning. The task presents significant difficulties for protein language models (PLMs) due to the sheer volume of functional annotation categories and…

Biomolecules · Quantitative Biology 2025-06-10 Zixuan Jiang , Renjing Xu

Multi-label learning is a challenging computer vision task that requires assigning multiple categories to each image. However, fully annotating large-scale datasets is often impractical due to high costs and effort, motivating the study of…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Luong Tran , Thieu Vo , Anh Nguyen , Sang Dinh , Van Nguyen

This paper proposes a novel framework for multi-label image recognition without any training data, called data-free framework, which uses knowledge of pre-trained Large Language Model (LLM) to learn prompts to adapt pretrained…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Shuo Yang , Zirui Shang , Yongqi Wang , Derong Deng , Hongwei Chen , Qiyuan Cheng , Xinxiao Wu

This paper focuses on three critical problems on protein classification. Firstly, Carbohydrate-active enzyme (CAZyme) classification can help people to understand the properties of enzymes. However, one CAZyme may belong to several classes.…

Biomolecules · Quantitative Biology 2023-02-23 Zhuangwei Shi , Bo Li
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