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While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Quantitative Methods · Quantitative Biology 2025-07-10 Changchun Yang , Haoyang Li , Yushuai Wu , Yilan Zhang , Yifeng Jiao , Yu Zhang , Rihan Huang , Yuan Cheng , Yuan Qi , Xin Guo , Xin Gao

Knowledge distillation is an effective method for training small and efficient deep learning models. However, the efficacy of a single method can degenerate when transferring to other tasks, modalities, or even other architectures. To…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Roy Miles , Ismail Elezi , Jiankang Deng

Vision foundation models (FMs) are accelerating the development of digital pathology algorithms and transforming biomedical research. These models learn, in a self-supervised manner, to represent histological features in highly…

Knowledge distillation is one of the most popular and effective techniques for knowledge transfer, model compression and semi-supervised learning. Most existing distillation approaches require the access to original or augmented training…

Machine Learning · Computer Science 2020-12-11 Liangchen Luo , Mark Sandler , Zi Lin , Andrey Zhmoginov , Andrew Howard

Cross-Domain Few-Shot Semantic Segmentation (CD-FSS) seeks to segment unknown classes in unseen domains using only a few annotated examples. This setting is inherently challenging: source and target domains exhibit substantial distribution…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Pasquale De Marinis , Pieter M. Blok , Uzay Kaymak , Rogier Brussee , Gennaro Vessio , Giovanna Castellano

Cancer subtyping is one of the most challenging tasks in digital pathology, where Multiple Instance Learning (MIL) by processing gigapixel whole slide images (WSIs) has been in the spotlight of recent research. However, MIL approaches do…

Large Genomic Foundation Models have recently achieved remarkable results and in-vivo translation capabilities. However these models quickly grow to over a few Billion of parameters and are expensive to run when compute is limited. To…

Machine Learning · Computer Science 2026-04-13 Rasched Haidari , Sam Martin , Maxime Allard

With the rapid development of computational pathology, many AI-assisted diagnostic tasks have emerged. Cellular nuclei segmentation can segment various types of cells for downstream analysis, but it relies on predefined categories and lacks…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Chunlin Zhong , Shuang Hao , Junhua Wu , Xiaona Chang , Jiwei Jiang , Xiu Nie , He Tang , Xiang Bai

Diffusion models have recently shown great promise for generative modeling, outperforming GANs on perceptual quality and autoregressive models at density estimation. A remaining downside is their slow sampling time: generating high quality…

Machine Learning · Computer Science 2022-06-08 Tim Salimans , Jonathan Ho

Point cloud processing has gained significant attention due to its critical role in applications such as autonomous driving and 3D object recognition. However, deploying high-performance models like Point Transformer V3 in…

Computer Vision and Pattern Recognition · Computer Science 2025-05-14 Luu Tung Hai , Thinh D. Le , Zhicheng Ding , Qing Tian , Truong-Son Hy

Audio-visual representation learning is crucial for advancing multimodal speech processing tasks, such as lipreading and audio-visual speech recognition. Recently, speech foundation models (SFMs) have shown remarkable generalization…

Audio and Speech Processing · Electrical Eng. & Systems 2025-02-11 Jing-Xuan Zhang , Genshun Wan , Jianqing Gao , Zhen-Hua Ling

Masked image modeling (MIM) learns representations with remarkably good fine-tuning performances, overshadowing previous prevalent pre-training approaches such as image classification, instance contrastive learning, and image-text…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Yixuan Wei , Han Hu , Zhenda Xie , Zheng Zhang , Yue Cao , Jianmin Bao , Dong Chen , Baining Guo

Model merging offers an effective way to integrate the capabilities of multiple fine-tuned models. However, the performance degradation of the merged model remains a challenge, particularly when none or few data are available. This paper…

Machine Learning · Computer Science 2025-05-28 Jing Xu , Jiazheng Li , Jingzhao Zhang

Whole-slide image analysis via the means of computational pathology often relies on processing tessellated gigapixel images with only slide-level labels available. Applying multiple instance learning-based methods or transformer models is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Joshua Butke , Noriaki Hashimoto , Ichiro Takeuchi , Hiroaki Miyoshi , Koichi Ohshima , Jun Sakuma

Diffusion models produce high-quality text-to-image results, but their iterative denoising is computationally expensive.Distribution Matching Distillation (DMD) emerges as a promising path to few-step distillation, but suffers from…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Haoyu Li , Tingyan Wen , Lin Qi , Zhe Wu , Yihuang Chen , Xing Zhou , Lifei Zhu , Xueqian Wang , Kai Zhang

Medical image understanding requires meticulous examination of fine visual details, with particular regions requiring additional attention. While radiologists build such expertise over years of experience, it is challenging for AI models to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Ying Jin , Zhuoran Zhou , Haoquan Fang , Jenq-Neng Hwang

We present a novel approach to knowledge transfer in model-based reinforcement learning, addressing the critical challenge of deploying large world models in resource-constrained environments. Our method efficiently distills a high-capacity…

Machine Learning · Computer Science 2025-07-03 Dmytro Kuzmenko , Nadiya Shvai

Processing giga-pixel whole slide histopathology images (WSI) is a computationally expensive task. Multiple instance learning (MIL) has become the conventional approach to process WSIs, in which these images are split into smaller patches…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Ramin Nakhli , Puria Azadi Moghadam , Haoyang Mi , Hossein Farahani , Alexander Baras , Blake Gilks , Ali Bashashati

Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Foundation models pre-trained with self-supervised learning (SSL) on large-scale datasets have become powerful general-purpose feature extractors. However, their immense size and computational cost make them prohibitive for deployment on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Guillaume Letellier , Siddharth Srivastava , Frédéric Jurie , Gaurav Sharma
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