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Automated protein function prediction is a challenging problem with distinctive features, such as the hierarchical organization of protein functions and the scarcity of annotated proteins for most biological functions. We propose a…

Machine Learning · Statistics 2019-04-09 Marco Frasca , Nicolò Cesa Bianchi

Multi-task learning (MTL) is to learn one single model that performs multiple tasks for achieving good performance on all tasks and lower cost on computation. Learning such a model requires to jointly optimize losses of a set of tasks with…

Computer Vision and Pattern Recognition · Computer Science 2020-09-25 Wei-Hong Li , Hakan Bilen

Annotation cost is a bottleneck for collecting massive data in mammography, especially for training deep neural networks. In this paper, we study the use of heterogeneous levels of annotation granularity to improve predictive performances.…

Image and Video Processing · Electrical Eng. & Systems 2019-09-13 Thi-Lam-Thuy Le , Nicolas Thome , Sylvain Bernard , Vincent Bismuth , Fanny Patoureaux

The accuracy of any machine learning potential can only be as good as the data used in the fitting process. The most efficient model therefore selects the training data that will yield the highest accuracy compared to the cost of obtaining…

Chemical Physics · Physics 2020-07-21 Anders S. Christensen , O. Anatole von Lilienfeld

Long-range electrostatics and polarization remain central obstacles to extending machine learning interatomic potentials (MLIPs) to ionic, polar, and interfacial systems. Here, we introduce a semi-local framework for learning electrostatics…

Materials Science · Physics 2026-05-08 Dongjin Kim , Daniel S. King , Yoonjae Park , Roya Savoj , Sebastien Hamel , Xiaoyu Wang , Bingqing Cheng

The predictive accuracy of Machine Learning (ML) models of molecular properties depends on the choice of the molecular representation. Based on the postulates of quantum mechanics, we introduce a hierarchy of representations which meet…

Chemical Physics · Physics 2016-11-23 Bing Huang , O. Anatole von Lilienfeld

Machine learning of scalar molecular properties such as potential energy has enabled widespread applications. However, there are relatively few machine learning models targeting directional properties, including permanent and transition…

Chemical Physics · Physics 2021-11-10 Yaolong Zhang , Jun Jiang , Bin Jiang

Multi-task learning promises better model generalization on a target task by jointly optimizing it with an auxiliary task. However, the current practice requires additional labeling efforts for the auxiliary task, while not guaranteeing…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Menelaos Kanakis , Thomas E. Huang , David Bruggemann , Fisher Yu , Luc Van Gool

Prediction for ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) plays a crucial role in drug discovery and development, accelerating the screening and optimization of new drugs. Existing methods primarily rely on…

Machine Learning · Computer Science 2025-09-08 Han Zhang , Fengji Ma , Jiamin Su , Xinyue Yang , Lei Wang , Wen-Cai Ye , Li Liu

A machine learning (ML) based equivariant neural network for constructing distributed charge models (DCMs) of arbitrary resolution, DCM-net, is presented. DCMs efficiently and accurately model the anisotropy of the molecular electrostatic…

Chemical Physics · Physics 2026-02-10 Eric D. Boittier , Markus Meuwly

The molecular electrostatic potential (MEP) is a key quantity for describing and predicting intermolecular and ion-molecule interactions. Here, we assess the ability of machine-learning (ML) models to infer the MEP, based on the equivariant…

Chemical Physics · Physics 2026-01-16 Kadri Muuga , Lisanne Knijff , Chao Zhang

Machine learning interatomic potentials (MLIPs) provide a computationally efficient alternative to quantum mechanical simulations for predicting material properties. Message-passing graph neural networks, commonly used in these MLIPs, rely…

Chemical Physics · Physics 2025-09-08 Moin Uddin Maruf , Sungmin Kim , Zeeshan Ahmad

Multi-task learning (MTL) is a subfield of machine learning in which multiple tasks are simultaneously learned by a shared model. Such approaches offer advantages like improved data efficiency, reduced overfitting through shared…

Machine Learning · Computer Science 2020-09-22 Michael Crawshaw

Accurate representation of the molecular electrostatic potential, which is often expanded in distributed multipole moments, is crucial for an efficient evaluation of intermolecular interactions. Here we introduce a machine learning model…

Chemical Physics · Physics 2017-10-09 Tristan Bereau , Denis Andrienko , O. Anatole von Lilienfeld

Multi-Task Learning (MTL) involves the concurrent training of multiple tasks, offering notable advantages for dense prediction tasks in computer vision. MTL not only reduces training and inference time as opposed to having multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 Maxime Fontana , Michael Spratling , Miaojing Shi

Multi-Task Learning (MTL) can enhance a classifier's generalization performance by learning multiple related tasks simultaneously. Conventional MTL works under the offline or batch setting, and suffers from expensive training cost and poor…

Machine Learning · Computer Science 2017-06-28 Peng Yang , Peilin Zhao , Xin Gao

Universal machine learned interatomic potentials (uMLIPs) embody a growing area of interest due to their transferability across the periodic table, displaying an error of about 0.6 kcal/mol against the Matbench Discovery test set. However,…

Materials Science · Physics 2026-03-12 Nicolas Wong , Julia H. Yang

Deep learning based models are used regularly in every applications nowadays. Generally we train a single model on a single task. However, we can train multiple tasks on a single model under multi-task learning settings. This provides us…

Machine Learning · Computer Science 2023-03-14 Aminul Huq , Mst Tasnim Pervin

Multitask Learning is a Machine Learning paradigm that aims to train a range of (usually related) tasks with the help of a shared model. While the goal is often to improve the joint performance of all training tasks, another approach is to…

Machine Learning · Computer Science 2024-05-14 Rafael Kourdis , Gabriel Gordon-Hall , Philip John Gorinski

This study extends the accurate and transferable molecular-orbital-based machine learning (MOB-ML) approach to modeling the contribution of electron correlation to dipole moments at the cost of Hartree-Fock computations. A…

Chemical Physics · Physics 2022-09-21 Jiace Sun , Lixue Cheng , Thomas F. Miller