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Clinical studies often require understanding elements of a patient's narrative that exist only in free text clinical notes. To transform notes into structured data for downstream use, these elements are commonly extracted and normalized to…

Computation and Language · Computer Science 2020-08-03 Monica Agrawal , Chloe O'Connell , Yasmin Fatemi , Ariel Levy , David Sontag

We present a novel approach to uncertainty quantification in classification tasks based on label-wise decomposition of uncertainty measures. This label-wise perspective allows uncertainty to be quantified at the individual class level,…

Machine Learning · Computer Science 2024-06-05 Yusuf Sale , Paul Hofman , Timo Löhr , Lisa Wimmer , Thomas Nagler , Eyke Hüllermeier

Clinical decision requires reasoning in the presence of imperfect data. DTs are a well-known decision support tool, owing to their interpretability, fundamental in safety-critical contexts such as medical diagnosis. However, learning DTs…

Automated decision support can accelerate tedious tasks as users can focus their attention where it is needed most. However, a key concern is whether users overly trust or cede agency to automation. In this paper, we investigate the effects…

Human-Computer Interaction · Computer Science 2021-03-30 Ariel Levy , Monica Agrawal , Arvind Satyanarayan , David Sontag

Medical image segmentation is inherently uncertain. For a given image, there may be multiple plausible segmentation hypotheses, and physicians will often disagree on lesion and organ boundaries. To be suited to real-world application,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 João Lourenço Silva , Arlindo L. Oliveira

Deep neural networks are known to be data-driven and label noise can have a marked impact on model performance. Recent studies have shown great robustness to classic image recognition even under a high noisy rate. In medical applications,…

Computer Vision and Pattern Recognition · Computer Science 2021-03-23 Lie Ju , Xin Wang , Lin Wang , Dwarikanath Mahapatra , Xin Zhao , Mehrtash Harandi , Tom Drummond , Tongliang Liu , Zongyuan Ge

Safe artificial intelligence for perception tasks remains a major challenge, partly due to the lack of data with high-quality labels. Annotations themselves are subject to aleatoric and epistemic uncertainty, which is typically ignored…

Machine Learning · Computer Science 2026-02-05 Jonathan Klees , Tobias Riedlinger , Peter Stehr , Bennet Böddecker , Daniel Kondermann , Matthias Rottmann

Uncertainty quantification in automated image analysis is highly desired in many applications. Typically, machine learning models in classification or segmentation are only developed to provide binary answers; however, quantifying the…

In the early stages of drug discovery, decisions regarding which experiments to pursue can be influenced by computational models. These decisions are critical due to the time-consuming and expensive nature of the experiments. Therefore, it…

Machine Learning · Computer Science 2024-09-09 Emma Svensson , Hannah Rosa Friesacher , Susanne Winiwarter , Lewis Mervin , Adam Arany , Ola Engkvist

We introduce dataset multiplicity, a way to study how inaccuracies, uncertainty, and social bias in training datasets impact test-time predictions. The dataset multiplicity framework asks a counterfactual question of what the set of…

Machine Learning · Computer Science 2023-04-24 Anna P. Meyer , Aws Albarghouthi , Loris D'Antoni

While multiple studies have explored the relation between inter-rater variability and deep learning model uncertainty in medical segmentation tasks, little is known about the impact of individual rater style. This study quantifies rater…

Computer Vision and Pattern Recognition · Computer Science 2021-05-06 Olivier Vincent , Charley Gros , Julien Cohen-Adad

Named Entity Recognition (NER) encounters the challenge of unbalanced labels, where certain entity types are overrepresented while others are underrepresented in real-world datasets. This imbalance can lead to biased models that perform…

Computation and Language · Computer Science 2024-09-06 Abdul Rehman , Jian Jun Zhang , Xiaosong Yang

Classifiers are often tested on relatively small data sets, which should lead to uncertain performance metrics. Nevertheless, these metrics are usually taken at face value. We present an approach to quantify the uncertainty of…

Machine Learning · Statistics 2021-03-05 Niklas Tötsch , Daniel Hoffmann

The development of medical science greatly depends on the increased utilization of machine learning algorithms. By incorporating machine learning, the medical imaging field can significantly improve in terms of the speed and accuracy of the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-01 Angona Biswas , MD Abdullah Al Nasim , Md Shahin Ali , Ismail Hossain , Md Azim Ullah , Sajedul Talukder

We propose an evaluation framework for class probability estimates (CPEs) in the presence of label uncertainty, which is commonly observed as diagnosis disagreement between experts in the medical domain. We also formalize evaluation metrics…

Machine Learning · Statistics 2021-03-23 Takahiro Mimori , Keiko Sasada , Hirotaka Matsui , Issei Sato

The use of AI systems in healthcare for the early screening of diseases is of great clinical importance. Deep learning has shown great promise in medical imaging, but the reliability and trustworthiness of AI systems limit their deployment…

Image and Video Processing · Electrical Eng. & Systems 2023-05-17 Ke Zou , Zhihao Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

The importance of uncertainty quantification is increasingly recognized in the diverse field of machine learning. Accurately assessing model prediction uncertainty can help provide deeper understanding and confidence for researchers and…

Machine Learning · Computer Science 2024-12-03 Tianyi Chen , Yingzhou Lu , Nan Hao , Yuanyuan Zhang , Capucine Van Rechem , Jintai Chen , Tianfan Fu

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-making tasks. One proposed safeguard is selective prediction, where models can defer…

Machine Learning · Computer Science 2026-05-25 L. Julián Lechuga López , Farah E. Shamout , Tim G. J. Rudner

Assessing uncertainty is an important step towards ensuring the safety and reliability of machine learning systems. Existing uncertainty estimation techniques may fail when their modeling assumptions are not met, e.g. when the data…

Machine Learning · Computer Science 2017-01-24 Volodymyr Kuleshov , Stefano Ermon

Human-generated categorical annotations frequently produce empirical response distributions (soft labels) that reflect ambiguity rather than simple annotator error. We introduce an ambiguity measure that maps a discrete response…

Machine Learning · Computer Science 2025-10-07 Christopher Klugmann , Daniel Kondermann