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Related papers: Shoot from the HIP: Hessian Interatomic Potentials…

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The Hessian matrix (second derivatives) encodes far richer local curvature of the potential energy surface than energies and forces alone. However, training machine-learning interatomic potentials (MLIPs) with full Hessians is often…

Local curvature of potential energy surfaces is critical for predicting certain experimental observables of molecules and materials from first principles, yet it remains far beyond reach for complex systems. In this work, we introduce a…

Machine Learning · Computer Science 2026-03-27 Bangchen Yin , Jian Ouyang , Zhen Fan , Kailai Lin , Hanshi Hu , Dingshun Lv , Weiluo Ren , Hai Xiao , Ji Chen , Changsu Cao

Integrating machine learning into reactive chemistry, materials discovery, and drug design is revolutionizing the development of novel molecules and materials. Machine Learning Interatomic Potentials (MLIPs) accurately predict energies and…

Chemical Physics · Physics 2025-07-04 Austin Rodriguez , Justin S. Smith , Jose L. Mendoza-Cortes

Predicting user influence in social networks is a critical problem, and hypergraphs, as a prevalent higher-order modeling approach, provide new perspectives for this task. However, the absence of explicit cascade or infection probability…

Social and Information Networks · Computer Science 2025-08-22 Su-Su Zhang , JinFeng Xie , Yang Chen , Min Gao , Cong Li , Chuang Liu , Xiu-Xiu Zhan

Differentiable programming is revolutionizing computational science by enabling automatic differentiation (AD) of numerical simulations. While first-order gradients are well-established, second-order derivatives (Hessians) for implicit…

Computational Engineering, Finance, and Science · Computer Science 2025-05-20 Tianju Xue

When training large models, such as neural networks, the full derivatives of order 2 and beyond are usually inaccessible, due to their computational cost. Therefore, among the second-order optimization methods, it is common to bypass the…

Machine Learning · Computer Science 2025-10-01 Pierre Wolinski

We present an equivariant neural network for predicting vibrational and phonon modes of molecules and periodic crystals, respectively. These predictions are made by evaluating the second derivative Hessian matrices of the learned energy…

Disordered Systems and Neural Networks · Physics 2024-03-19 Shiang Fang , Mario Geiger , Joseph G. Checkelsky , Tess Smidt

In this article we present a machine learning model to obtain fast and accurate estimates of the molecular Hessian matrix. In this model, based on a random forest, the second derivatives of the energy with respect to redundant internal…

Chemical Physics · Physics 2024-01-10 Giorgio Domenichini , Christoph Dellago

In this work we develop a Hessian-based sampling method for the construction of goal-oriented reduced order models with high-dimensional parameter inputs. Model reduction is known very challenging for high-dimensional parametric problems…

Numerical Analysis · Mathematics 2018-09-28 Peng Chen , Omar Ghattas

Access to the potential energy Hessian enables determination of the Gibbs free energy, and certain approaches to transition state search and optimization. Here, we demonstrate that off-the-shelf pretrained Open Catalyst Project (OCP)…

Materials Science · Physics 2024-10-08 Brook Wander , Joseph Musielewicz , Raffaele Cheula , John R. Kitchin

In this work we develop Curvature Propagation (CP), a general technique for efficiently computing unbiased approximations of the Hessian of any function that is computed using a computational graph. At the cost of roughly two gradient…

Machine Learning · Computer Science 2012-09-05 James Martens , Ilya Sutskever , Kevin Swersky

A computational procedure is developed for the efficient calculation of derivatives of integrals over non-separable Gaussian-type basis functions, used for the evaluation of gradients of the total energy in quantum-mechanical simulations.…

Materials Science · Physics 2023-05-03 Jacques K. Desmarais , Alessandro De Frenza , Alessandro Erba

We introduce the Hierarchically Interacting Particle Neural Network (HIP-NN) to model molecular properties from datasets of quantum calculations. Inspired by a many-body expansion, HIP-NN decomposes properties, such as energy, as a sum over…

Machine Learning · Statistics 2018-04-04 Nicholas Lubbers , Justin S. Smith , Kipton Barros

Hessian-free training has become a popular parallel second or- der optimization technique for Deep Neural Network training. This study aims at speeding up Hessian-free training, both by means of decreasing the amount of data used for…

Machine Learning · Computer Science 2013-12-11 Tara N. Sainath , Lior Horesh , Brian Kingsbury , Aleksandr Y. Aravkin , Bhuvana Ramabhadran

A significant challenge in computational chemistry is developing approximations that accelerate \emph{ab initio} methods while preserving accuracy. Machine learning interatomic potentials (MLIPs) have emerged as a promising solution for…

Crystal structures can be predicted from first-principles using ab initio random structure searching AIRSS and density functional theory (DFT). AIRSS provides a method to sample the potential energy landscape and DFT provides a robust and…

Materials Science · Physics 2025-09-30 Lewis J. Conway , Chris J. Pickard

Second derivatives of mathematical models for real-world phenomena are fundamental ingredients of a wide range of numerical simulation methods including parameter sensitivity analysis, uncertainty quantification, nonlinear optimization and…

Mathematical Software · Computer Science 2021-10-27 Uwe Naumann , Shubhaditya Burela

Deep Gaussian processes have recently been proposed as natural objects to fit, similarly to deep neural networks, possibly complex features present in modern data samples, such as compositional structures. Adopting a Bayesian nonparametric…

Statistics Theory · Mathematics 2025-02-04 Ismaël Castillo , Thibault Randrianarisoa

We propose an algorithm for inexpensive gradient-based hyperparameter optimization that combines the implicit function theorem (IFT) with efficient inverse Hessian approximations. We present results about the relationship between the IFT…

Machine Learning · Computer Science 2019-11-11 Jonathan Lorraine , Paul Vicol , David Duvenaud

In this paper, we propose a second order optimization method to learn models where both the dimensionality of the parameter space and the number of training samples is high. In our method, we construct on each iteration a Krylov subspace…

Machine Learning · Statistics 2011-11-21 Oriol Vinyals , Daniel Povey
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