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Advancements in high-throughput technologies have led to a shift from traditional hypothesis-driven methodologies to data-driven approaches. Multi-omics refers to the integrative analysis of data derived from multiple 'omes', such as…

Genomics · Quantitative Biology 2024-10-17 Ahmad Hussein , Mukesh Prasad , Ali Braytee

Accurate cancer survival prediction requires integration of diverse data modalities that reflect the complex interplay between imaging, clinical parameters, and textual reports. However, existing multimodal approaches suffer from simplistic…

Machine Learning · Computer Science 2025-07-01 Aakash Tripathi , Asim Waqas , Matthew B. Schabath , Yasin Yilmaz , Ghulam Rasool

Model interpretability is crucial for establishing AI safety and clinician trust in medical applications for example, in survival modelling with competing risks. Recent deep learning models have attained very good predictive performance but…

Machine Learning · Computer Science 2026-01-26 Dhanesh Ramachandram , Anne Loefler , Surain Roberts , Amol Verma , Maia Norman , Fahad Razak , Conrad Pow , Charles de Mestral

Radiology is essential to modern healthcare, yet rising demand and staffing shortages continue to pose major challenges. Recent advances in artificial intelligence have the potential to support radiologists and help address these…

Image and Video Processing · Electrical Eng. & Systems 2025-11-14 Phillip Sloan , Edwin Simpson , Majid Mirmehdi

When drawing causal inferences about the effects of multiple treatments on clustered survival outcomes using observational data, we need to address implications of the multilevel data structure, multiple treatments, censoring and unmeasured…

Methodology · Statistics 2022-02-18 Liangyuan Hu , Jiayi Ji , Ronald D. Ennis , Joseph W. Hogan

Machine learning models are increasingly applied to biomedical data, yet their adoption in high stakes domains remains limited by poor robustness, limited interpretability, and instability of learned features under realistic data…

Machine Learning · Computer Science 2026-02-20 Justyna Andrys-Olek , Paulina Tworek , Luca Gherardini , Mark W. Ruddock , Mary Jo Kurt , Peter Fitzgerald , Jose Sousa

Cancer prognosis is a critical task that involves predicting patient outcomes and survival rates. To enhance prediction accuracy, previous studies have integrated diverse data modalities, such as clinical notes, medical images, and genomic…

Machine Learning · Computer Science 2025-02-04 Jie Peng , Shuang Zhou , Longwei Yang , Yiran Song , Mohan Zhang , Kaixiong Zhou , Feng Xie , Mingquan Lin , Rui Zhang , Tianlong Chen

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Integrating artificial intelligence (AI) with healthcare data is rapidly transforming medical diagnostics and driving progress toward precision medicine. However, effectively leveraging multimodal data, particularly digital pathology whole…

Image and Video Processing · Electrical Eng. & Systems 2025-12-15 Areej Alsaafin , Abubakr Shafique , Saghir Alfasly , Krishna R. Kalari , H. R. Tizhoosh

Lung cancer has the highest mortality rate of deadly cancers in the world. Early detection is essential to treatment of lung cancer. However, detection and accurate diagnosis of pulmonary nodules depend heavily on the experiences of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Chenglong Wang , Yun Liu , Fen Wang , Chengxiu Zhang , Yida Wang , Mei Yuan , Guang Yang

Cancer is one of the leading causes of death worldwide, making the development of rapid, minimally invasive, label-free and scalable diagnostic strategies a major challenge in modern oncology. In this context, spectroscopic liquid biopsy…

Accurate survival prediction is essential for personalized cancer treatment. However, genomic data - often a more powerful predictor than pathology data - is costly and inaccessible. We present the cross-modal genomic feature translation…

Image and Video Processing · Electrical Eng. & Systems 2024-11-04 Akhila Krishna , Nikhil Cherian Kurian , Abhijeet Patil , Amruta Parulekar , Amit Sethi

Survival analysis is essential for studying time-to-event outcomes and providing a dynamic understanding of the probability of an event occurring over time. Various survival analysis techniques, from traditional statistical models to…

Machine Learning · Computer Science 2024-03-13 Ziwen Wang , Jin Wee Lee , Tanujit Chakraborty , Yilin Ning , Mingxuan Liu , Feng Xie , Marcus Eng Hock Ong , Nan Liu

The proliferation of deepfake technologies poses urgent challenges and serious risks to digital integrity, particularly within critical sectors such as forensics, journalism, and the legal system. While existing detection systems have made…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Shahroz Tariq , Simon S. Woo , Priyanka Singh , Irena Irmalasari , Saakshi Gupta , Dev Gupta

Biofouling$\unicode{x2013}$communities of organisms that grow on hard surfaces immersed in water$\unicode{x2013}$provides a pathway for the spread of invasive marine species and diseases. To address this risk, international vessels are…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Evelyn J. Mannix , Bartholomew A. Woodham

Deriving interpretable prognostic features from deep-learning-based prognostic histopathology models remains a challenge. In this study, we developed a deep learning system (DLS) for predicting disease specific survival for stage II and III…

A new ensemble framework for interpretable model called Linear Iterative Feature Embedding (LIFE) has been developed to achieve high prediction accuracy, easy interpretation and efficient computation simultaneously. The LIFE algorithm is…

Machine Learning · Statistics 2021-03-19 Agus Sudjianto , Jinwen Qiu , Miaoqi Li , Jie Chen

Feature-based methods are commonly used to explain model predictions, but these methods often implicitly assume that interpretable features are readily available. However, this is often not the case for high-dimensional data, and it can be…

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Chenglong Wang , Yinqiao Yi , Yida Wang , Chengxiu Zhang , Yun Liu , Kensaku Mori , Mei Yuan , Guang Yang

Deep CNNs have been pushing the frontier of visual recognition over past years. Besides recognition accuracy, strong demands in understanding deep CNNs in the research community motivate developments of tools to dissect pre-trained models…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Bangjie Yin , Luan Tran , Haoxiang Li , Xiaohui Shen , Xiaoming Liu
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