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Related papers: QUBOLite: A lightweigth Python toolkit for QUBO

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This paper introduces CUQIpy, a versatile open-source Python package for computational uncertainty quantification (UQ) in inverse problems, presented as Part I of a two-part series. CUQIpy employs a Bayesian framework, integrating prior…

Qubit-efficient optimization studies how large combinatorial problems can be addressed with quantum circuits whose width is far smaller than the number of logical variables. In quadratic unconstrained binary optimization (QUBO), objective…

Quantum Physics · Physics 2026-01-13 Gordon Ma , Dimitris G. Angelakis

Understanding the best known parameters, performance, and systematic behavior of the Quantum Approximate Optimization Algorithm (QAOA) remain open research questions, even as the algorithm gains popularity. We introduce QAOAKit, a Python…

Quantum Physics · Physics 2022-04-19 Ruslan Shaydulin , Kunal Marwaha , Jonathan Wurtz , Phillip C. Lotshaw

The peptide-protein docking problem is an important problem in structural biology that facilitates rational and efficient drug design. In this work, we explore modeling and solving this problem with the quantum-amenable quadratic…

Combinatorial optimization problems are typically formulated using Quadratic Unconstrained Binary Optimization (QUBO), where constraints are enforced through penalty terms that introduce auxiliary variables and rapidly increase Hamiltonian…

Quantum Physics · Physics 2026-02-10 Shashank Sanjay Bhat , Peiyong Wang , Joseph West , Udaya Parampalli

Combinatorial optimization problems are pivotal across many fields. Among these, Quadratic Unconstrained Binary Optimization (QUBO) problems, central to fields like portfolio optimization, network design, and computational biology, are…

Optimization and Control · Mathematics 2024-06-07 Yuhan Huang , Siyuan Jin , Yichi Zhang , Ling Pan , Qiming Shao

In the recent years, numerous research advancements have extended the limit of classical simulation of quantum algorithms. Although, most of the state-of-the-art classical simulators are only limited to binary quantum systems, which…

Quantum annealing is a promising approach for solving combinatorial optimization problems. However, its performance is often limited by the overhead of additional qubits required for embedding logical QUBO models onto quantum annealers.…

Quantum Physics · Physics 2026-01-27 Kohei Suda , Soshun Naito , Yoshihiko Hasegawa

Today, hardware constraints are an important limitation on quantum adiabatic optimization algorithms. Firstly, computational problems must be formulated as quadratic unconstrained binary optimization (QUBO) in the presence of noisy coupling…

Quantum Physics · Physics 2018-12-06 Andrew Lucas

Quantum Approximate Optimization Algorithm (QAOA) can be used to solve quadratic unconstrained binary optimization (QUBO) problems. However, the size of the solvable problem is limited by the number of qubits. To leverage noisy…

Quantum Physics · Physics 2025-06-10 Wending Zhao , Gaoxiang Tang

Modular quantum computing architectures are a promising alternative to monolithic QPU (Quantum Processing Unit) designs for scaling up quantum devices. They refer to a set of interconnected QPUs or cores consisting of tightly coupled…

Programming-by-Example (PBE) systems synthesize an intended program in some (relatively constrained) domain-specific language from a small number of input-output examples provided by the user. In this paper, we motivate and define the…

Programming Languages · Computer Science 2019-09-16 Sumit Gulwani , Kunal Pathak , Arjun Radhakrishna , Ashish Tiwari , Abhishek Udupa

Many of the envisioned use-cases for quantum computers involve optimisation processes. While there are many algorithmic primitives to perform the required calculations, all eventually lead to quantum gates operating on quantum bits, with an…

Quantum Physics · Physics 2026-03-26 Lukas Schmidbauer , Elisabeth Lobe , Ina Schaefer , Wolfgang Mauerer

Quantified Integer Programming (QIP) bridges multiple domains by extending Quantified Boolean Formulas (QBF) to incorporate general integer variables and linear constraints while also generalizing Integer Programming through variable…

Discrete Mathematics · Computer Science 2025-06-06 Michael Hartisch , Leroy Chew

We introduce a novel approach to translate arbitrary 3-SAT instances to Quadratic Unconstrained Binary Optimization (QUBO) as they are used by quantum annealing (QA) or the quantum approximate optimization algorithm (QAOA). Our approach…

Variational Quantum Algorithms (VQAs) provide a promising framework for tackling complex optimization problems on near-term quantum hardware. Here, we demonstrate that hybrid qubit--qumode quantum devices offer an efficient route to solving…

Quantum Approximate Optimization Algorithm (QAOA) and Quantum Annealing are prominent approaches for solving combinatorial optimization problems, such as those formulated as Quadratic Unconstrained Binary Optimization (QUBO). These…

Due to the expected disparity in quantum vs. classical clock speeds, quantum advantage for branch and bound algorithms is more likely achievable in settings involving large search trees and low operator evaluation costs. Therefore, in this…

Optimization and Control · Mathematics 2024-07-30 Thomas Häner , Kyle E. C. Booth , Sima E. Borujeni , Elton Yechao Zhu

Quadratic unconstrained binary optimization (QUBO) is a field of operations research that is attracting growing interest due to the recent availability of quantum hardware targeted at solving QUBO problems. However, practical adoption is…

Software Engineering · Computer Science 2026-01-22 Lodovica Marchesi , Amal Nasharti , Michele Marchesi

We present an object-oriented open-source framework for solving the dynamics of open quantum systems written in Python. Arbitrary Hamiltonians, including time-dependent systems, may be built up from operators and states defined by a quantum…

Quantum Physics · Physics 2012-04-27 J. R. Johansson , P. D. Nation , Franco Nori
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