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Recombination is an important event in the evolution of HIV. It affects the global spread of the pandemic as well as evolutionary escape from host immune response and from drug therapy within single patients. Comprehensive computational…

Genomics · Quantitative Biology 2007-05-23 Niko Beerenwinkel , Colin N. Dewey , Kevin M. Woods

The growth in Remote Patient Monitoring (RPM) services using wearable and non-wearable Internet of Medical Things (IoMT) promises to improve the quality of diagnosis and facilitate timely treatment for a gamut of medical conditions. At the…

Machine Learning · Computer Science 2021-06-23 Deepti Gupta , Maanak Gupta , Smriti Bhatt , Ali Saman Tosun

Actigraphy is widely used in sleep studies but lacks a universal unsupervised algorithm for sleep/wake identification. In this study, we proposed a Hidden Markov Model (HMM) based unsupervised algorithm that can automatically and…

Applications · Statistics 2020-04-10 Xinyue Li , Yunting Zhang , Fan Jiang , Hongyu Zhao

The proliferation of malware variants poses a significant challenges to traditional malware detection approaches, such as signature-based methods, necessitating the development of advanced machine learning techniques. In this research, we…

Machine Learning · Computer Science 2024-12-30 Ritik Mehta , Olha Jureckova , Mark Stamp

We introduce PyHHMM, an object-oriented open-source Python implementation of Heterogeneous-Hidden Markov Models (HHMMs). In addition to HMM's basic core functionalities, such as different initialization algorithms and classical observations…

Mathematical Software · Computer Science 2022-01-19 Fernando Moreno-Pino , Emese Sükei , Pablo M. Olmos , Antonio Artés-Rodríguez

New types of high-resolution animal movement data allow for increasingly comprehensive biological inference, but method development to meet the statistical challenges associated with such data is lagging behind. In this contribution, we…

Methodology · Statistics 2025-07-08 Ferdinand V. Stoye , Annika Hoyer , Roland Langrock

We study the frontier between learnable and unlearnable hidden Markov models (HMMs). HMMs are flexible tools for clustering dependent data coming from unknown populations. The model parameters are known to be fully identifiable (up to…

Machine Learning · Statistics 2022-10-25 Kweku Abraham , Zacharie Naulet , Elisabeth Gassiat

$\textbf{Objective}$: To develop a multi-channel device event segmentation and feature extraction algorithm that is robust to changes in data distribution. $\textbf{Methods}$: We introduce an adaptive transfer learning algorithm to classify…

Signal Processing · Electrical Eng. & Systems 2020-11-24 Xichen She , Yaya Zhai , Ricardo Henao , Christopher W. Woods , Christopher Chiu , Geoffrey S. Ginsburg , Peter X. K. Song , Alfred O. Hero

Movement drives the spread of infectious disease, gene flow, and other critical ecological processes. To study these processes we need models for movement that capture complex behavior that changes over time and space in response to biotic…

Applications · Statistics 2016-06-28 Ephraim M. Hanks , David A. Hughes

The main focus of this work is on developing models for the activity profile of a terrorist group, detecting sudden spurts and downfalls in this profile, and, in general, tracking it over a period of time. Toward this goal, a $d$-state…

Applications · Statistics 2014-01-16 Vasanthan Raghavan , Aram Galstyan , Alexander G. Tartakovsky

Asset health monitoring continues to be of increasing importance on productivity, reliability, and cost reduction. Early Fault detection is a keystone of health management as part of the emerging Prognostics and Health Management (PHM)…

Machine Learning · Computer Science 2021-04-22 Akthem Rehab , Islam Ali , Walid Gomaa , M. Nashat Fors

Hidden Markov models (HMMs) and partially observable Markov decision processes (POMDPs) form a useful tool for modeling dynamical systems. They are particularly useful for representing environments such as road networks and office…

Artificial Intelligence · Computer Science 2013-01-30 Hagit Shatkay

We demonstrate the application of pattern recognition algorithms via hidden Markov models (HMM) for qubit readout. This scheme provides a state-path trajectory approach capable of detecting qubit state transitions and makes for a robust…

Quantum Physics · Physics 2021-01-04 Luis A. Martinez , Yaniv J. Rosen , Jonathan L. DuBois

Surface electromyography (sEMG) has gained significant importance during recent advancements in consumer electronics for healthcare systems, gesture analysis and recognition and sign language communication. For such a system, it is…

Signal Processing · Electrical Eng. & Systems 2020-05-04 Rinki Gupta , Karush Suri

Gait analysis is critical in the early detection and intervention of motor neurological disorders in infants. Despite its importance, traditional methods often struggle to model the high variability and rapid developmental changes inherent…

1. Hidden Markov models (HMMs) are powerful tools for modelling time-series data with underlying state structure. However, selecting appropriate parametric forms for the state-dependent distributions is often challenging and can lead to…

Human mobility forms the backbone of contact patterns through which infectious diseases propagate, fundamentally shaping the spatio-temporal dynamics of epidemics and pandemics. While traditional models are often based on the assumption…

The use of accelerometers in wildlife tracking provides a fine-scale data source for understanding animal behavior and decision-making. Current methods in movement ecology focus on behavior as a driver of movement mechanisms. Our Markov…

Behaviors of several laboratory animals can be modeled as sequences of stereotyped behaviors, or behavioral motifs. However, identifying such motifs is a challenging problem. Behaviors have a multi-scale structure: the animal can be…

Quantitative Methods · Quantitative Biology 2021-05-12 Haozhe Shan , Peggy Mason

We address the problem of analyzing sets of noisy time-varying signals that all report on the same process but confound straightforward analyses due to complex inter-signal heterogeneities and measurement artifacts. In particular we…

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