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Instrumental variable analysis is a widely used method to estimate causal effects in the presence of unmeasured confounding. When the instruments, exposure and outcome are not measured in the same sample, Angrist and Krueger (1992)…

Statistics Theory · Mathematics 2018-09-07 Qingyuan Zhao , Jingshu Wang , Jack Bowden , Dylan S. Small

With the violation of the assumption of homoskedasticity, least squares estimators of the variance become inefficient and statistical inference conducted with invalid standard errors leads to misleading rejection rates. Despite a vast…

Econometrics · Economics 2024-01-01 Annalivia Polselli

Epidemiologic and genetic studies in chronic obstructive pulmonary disease (COPD) and many complex diseases suggest subgroup disparities (e.g., by sex). We consider this problem from the standpoint of integrative analysis where we combine…

Methodology · Statistics 2023-09-26 J. Butts , C. Wendt , R. Bowler , C. P. Hersh , Q. Long , L. Eberly , S. E. Safo

We give analytic methods for nonparametric bias reduction that remove the need for computationally intensive methods like the bootstrap and the jackknife. We call an estimate {\it $p$th order} if its bias has magnitude $n_0^{-p}$ as $n_0…

Methodology · Statistics 2009-03-18 Christopher S. Withers , Saralees Nadarajah

Instrumental variable (IV) analyses are becoming common in health services research and epidemiology. Most IV analyses use naturally occurring instruments, such as distance to a hospital. In these analyses, investigators must assume the…

Methodology · Statistics 2019-07-04 Zach Branson , Luke Keele

In an instrumental variable model, the score statistic can be bounded for any alternative in parts of the parameter space. These regions involve a constraint on the first-stage regression coefficients and the reduced-form covariance matrix.…

Statistics Theory · Mathematics 2021-09-13 Marcelo J. Moreira , Geert Ridder

Knee osteoarthritis (OA) is one of the highest disability factors in the world. This musculoskeletal disorder is assessed from clinical symptoms, and typically confirmed via radiographic assessment. This visual assessment done by a…

Image and Video Processing · Electrical Eng. & Systems 2020-08-13 Huy Hoang Nguyen , Simo Saarakkala , Matthew Blaschko , Aleksei Tiulpin

In this work we propose a framework for constructing goodness of fit tests in both low and high-dimensional linear models. We advocate applying regression methods to the scaled residuals following either an ordinary least squares or Lasso…

Methodology · Statistics 2017-04-11 Rajen D. Shah , Peter Bühlmann

We develop new methods for constructing confidence sets and intervals in linear instrumental variables (IV) models based on tests that remain valid under weak identification and under heteroskedastic, autocorrelated, or clustered errors. In…

Econometrics · Economics 2026-04-07 Gustavo Schlemper , Marcelo J. Moreira

Meta-analysis combines pertinent information from existing studies to provide an overall estimate of population parameters/effect sizes, as well as to quantify and explain the differences between studies. However, testing the between-study…

Methodology · Statistics 2020-11-13 Han Du , Ge Jiang , Zijun Ke

The classical tests in the instrumental variable model can behave arbitrarily if the data is contaminated. For instance, one outlying observation can be enough to change the outcome of a test. We develop a framework to construct testing…

Econometrics · Economics 2024-03-26 Jens Klooster , Mikhail Zhelonkin

Cardiac muscle tissue exhibits highly non-linear hyperelastic and orthotropic material behavior during passive deformation. Traditional constitutive identification protocols therefore combine multiple loading modes and typically require…

Tissues and Organs · Quantitative Biology 2026-05-05 Rogier P. Krijnen , Akshay Joshi , Siddhant Kumar , Mathias Peirlinck

"Effective robustness" measures the extra out-of-distribution (OOD) robustness beyond what can be predicted from the in-distribution (ID) performance. Existing effective robustness evaluations typically use a single test set such as…

Machine Learning · Computer Science 2023-10-31 Zhouxing Shi , Nicholas Carlini , Ananth Balashankar , Ludwig Schmidt , Cho-Jui Hsieh , Alex Beutel , Yao Qin

Cryo-electron microscopy is a revolutionary technique that can provide 3D density maps at near-atomic resolution. However, map validation is still an open issue in the field. Despite several efforts from the community, it is possible to…

Biological Physics · Physics 2019-08-06 Sebastian Ortiz , Luka Stanisic , Boris A Rodriguez , Markus Rampp , Gerhard Hummer , Pilar Cossio

Interstitial lung diseases (ILD) present diagnostic challenges due to their varied manifestations and overlapping imaging features. To address this, we propose a machine learning approach that utilizes CLIP, a multimodal (image and text)…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Cara Van Uden , Christian Bluethgen , Maayane Attias , Malgorzata Polacin , Haiwei Henry Guo , Neha Simha , Rishi Raj , Curtis Langlotz

We address the problem of testing weak optimality of a given solution of a given interval linear program. The problem was recently wrongly stated to be polynomially solvable. We disprove it. We show that the problem is NP-hard in general.…

Optimization and Control · Mathematics 2025-10-08 Miroslav Rada , Milan Hladík , Elif Garajová

With the growing availability of machine-learned interatomic potential (MLIP) models for materials simulations, there is an increasing demand for robust, automated, and chemically insightful benchmarking methodologies. In response, we here…

Materials Science · Physics 2025-11-21 Natascia L. Fragapane , Volker L. Deringer

The doubly-robust (DR) estimator is popular for evaluating causal effects in observational studies and is often perceived as more desirable than inverse probability weighting (IPW) or outcome modeling alone because it provides extra…

Methodology · Statistics 2026-02-03 Chengxin Yang , Laine E. Thomas , Fan Li

In this paper, we study the strong consistency of a bias reduced kernel density estimator and derive a strongly con- sistent Kullback-Leibler divergence (KLD) estimator. As application, we formulate a goodness-of-fit test and an…

Methodology · Statistics 2018-05-21 Papa Ngom , Freedath Djibril Moussa , Jean de Dieu Nkurunziza

In big data analysis for detecting rare and weak signals among $n$ features, some grouping-test methods such as Higher Criticism test (HC), Berk-Jones test (B-J), and $\phi$-divergence test share the similar asymptotical optimality when $n…

Statistics Theory · Mathematics 2017-02-24 Hong Zhang , Jiashun Jin , Zheyang Wu