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Digital twins promise to revolutionize engineering by offering new avenues for optimization, control, and predictive maintenance. We propose a novel framework for simultaneously training the digital twin of an engineering system and an…

Systems and Control · Electrical Eng. & Systems 2024-07-12 Lorenzo Schena , Pedro Marques , Romain Poletti , Samuel Ahizi , Jan Van den Berghe , Miguel A. Mendez

The convergence of modeling & simulation (M&S) and artificial intelligence (AI) is leaving its marks on advanced digital technology. Pertinent examples are digital twins (DTs) - high-fidelity, live representations of physical assets, and…

Artificial Intelligence · Computer Science 2026-02-24 Philipp Zech , Istvan David

Neural ordinary differential equations (Neural ODEs) propose the idea that a sequence of layers in a neural network is just a discretisation of an ODE, and thus can instead be directly modelled by a parameterised ODE. This idea has had…

Machine Learning · Computer Science 2024-05-07 Christina Runkel , Ander Biguri , Carola-Bibiane Schönlieb

Numerical solutions of partial differential equations (PDEs) require expensive simulations, limiting their application in design optimization, model-based control, and large-scale inverse problems. Surrogate modeling techniques seek to…

Computational Physics · Physics 2022-05-18 James Duvall , Karthik Duraisamy , Shaowu Pan

Predicting the evolution of systems that exhibit spatio-temporal dynamics in response to external stimuli is a key enabling technology fostering scientific innovation. Traditional equations-based approaches leverage first principles to…

Machine Learning · Computer Science 2023-05-02 Francesco Regazzoni , Stefano Pagani , Matteo Salvador , Luca Dede' , Alfio Quarteroni

This paper presents a proof-of-concept digital twin framework for simulation-driven diabetes modeling using benchmark clinical data, synthetic temporal augmentation, and illustrative continuous glucose monitoring (CGM) analysis. Unlike…

Machine Learning · Computer Science 2026-05-13 Zarrin Monirzadeh

We articulate the design imperatives for machine-learning based digital twins for nonlinear dynamical systems subject to external driving, which can be used to monitor the ``health'' of the target system and anticipate its future collapse.…

Adaptation and Self-Organizing Systems · Physics 2022-10-13 Ling-Wei Kong , Yang Weng , Bryan Glaz , Mulugeta Haile , Ying-Cheng Lai

Human digital twins (HDTs) are dynamic, data-driven virtual representations of individuals, continuously updated with multimodal data to simulate, monitor, and predict health trajectories. By integrating clinical, physiological, behavioral,…

Human-Computer Interaction · Computer Science 2025-08-19 Rong Pan , Hongyue Sun , Xiaoyu Chen , Giulia Pedrielli , Jiapeng Huang

The integration of accurate and reproducible wireless network simulations is a key enabler for research on open, virtualized, and intelligent communication systems. Network Digital Twins (NDTs) provide a scalable alternative to costly and…

Networking and Internet Architecture · Computer Science 2026-04-15 Oscar Stenhammar , Sundeep Rangan , Gábor Fodor , Carlo Fischione

The concept of Hybrid Twin (HT) has recently received a growing interest thanks to the availability of powerful machine learning techniques. This twin concept combines physics-based models within a model-order reduction framework-to obtain…

Very recently, a variety of vision transformer architectures for dense prediction tasks have been proposed and they show that the design of spatial attention is critical to their success in these tasks. In this work, we revisit the design…

Computer Vision and Pattern Recognition · Computer Science 2021-10-01 Xiangxiang Chu , Zhi Tian , Yuqing Wang , Bo Zhang , Haibing Ren , Xiaolin Wei , Huaxia Xia , Chunhua Shen

Cardiac digital twins provide a physics and physiology informed framework to deliver predictive and personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to adoption due to their extensive computational…

Numerical Analysis · Mathematics 2023-06-09 Matteo Salvador , Marina Strocchi , Francesco Regazzoni , Luca Dede' , Steven Niederer , Alfio Quarteroni

As an emerging technology in the era of Industry 4.0, digital twin is gaining unprecedented attention because of its promise to further optimize process design, quality control, health monitoring, decision and policy making, and more, by…

Computational Engineering, Finance, and Science · Computer Science 2022-10-03 Adam Thelen , Xiaoge Zhang , Olga Fink , Yan Lu , Sayan Ghosh , Byeng D. Youn , Michael D. Todd , Sankaran Mahadevan , Chao Hu , Zhen Hu

Digital Twins (DTs) offer powerful tools for managing complex infrastructure systems, but their effectiveness is often limited by challenges in integrating unstructured knowledge. Recent advances in Large Language Models (LLMs) bring new…

Emerging Technologies · Computer Science 2026-05-19 Naiyi Li , Zihui Ma , Runlong Yu , Lingyao Li

This work presents a probabilistic digital twin framework for response prediction in dynamical systems governed by misspecified physics. The approach integrates Gaussian Process Latent Force Models (GPLFM) and Bayesian Neural Networks…

Machine Learning · Computer Science 2025-12-01 Sahil Kashyap , Rajdip Nayek

Operator regression provides a powerful means of constructing discretization-invariant emulators for partial-differential equations (PDEs) describing physical systems. Neural operators specifically employ deep neural networks to approximate…

Machine Learning · Computer Science 2023-04-18 Katiana Kontolati , Somdatta Goswami , George Em Karniadakis , Michael D. Shields

Robotic surgery imposes a significant cognitive burden on the surgeon. This cognitive burden increases in the case of remote robotic surgeries due to latency between entities and thus might affect the quality of surgery. Here, the patient…

Neural networks are one tool for approximating non-linear differential equations used in scientific computing tasks such as surrogate modeling, real-time predictions, and optimal control. PDE foundation models utilize neural networks to…

Machine Learning · Computer Science 2025-02-11 Elisa Negrini , Yuxuan Liu , Liu Yang , Stanley J. Osher , Hayden Schaeffer

The concept of creating a virtual copy of a complete Cyber-Physical System opens up numerous possibilities, including real-time assessments of the physical environment and continuous learning from the system to provide reliable and precise…

Artificial Intelligence · Computer Science 2023-11-22 Carine Menezes Rebello , Johannes Jäschkea , Idelfonso B. R. Nogueira

Digital twin technology has a huge potential for widespread applications in different industrial sectors such as infrastructure, aerospace, and automotive. However, practical adoptions of this technology have been slower, mainly due to a…

Machine Learning · Statistics 2020-06-16 Souvik Chakraborty , Sondipon Adhikari
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