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Recent technological advances have expanded the availability of high-throughput biological datasets, enabling the reliable design of digital twins of biomedical systems or patients. Such computational tools represent key reaction networks…

Quantitative Methods · Quantitative Biology 2025-09-03 Clémence Métayer , Annabelle Ballesta , Julien Martinelli

Digital Twins, virtual replicas of physical systems that enable real-time monitoring, model updates, predictions, and decision-making, present novel avenues for proactive control strategies for autonomous systems. However, achieving…

Systems and Control · Electrical Eng. & Systems 2025-05-08 Yi-Ping Chen , Ying-Kuan Tsai , Vispi Karkaria , Wei Chen

We present a goal-oriented framework for constructing digital twins with the following properties: (1) they employ discretizations of high-fidelity PDE models governed by autonomous dynamical systems, leading to large-scale forward…

Numerical Analysis · Mathematics 2026-01-22 Stefan Henneking , Sreeram Venkat , Omar Ghattas

Simulating the time evolution of Partial Differential Equations (PDEs) of large-scale systems is crucial in many scientific and engineering domains such as fluid dynamics, weather forecasting and their inverse optimization problems.…

Machine Learning · Computer Science 2022-10-13 Tailin Wu , Takashi Maruyama , Jure Leskovec

Ordinary and partial differential equations (ODEs/PDEs) play a paramount role in analyzing and simulating complex dynamic processes across all corners of science and engineering. In recent years machine learning tools are aspiring to…

Machine Learning · Computer Science 2021-06-11 Sifan Wang , Paris Perdikaris

Digital twin technology has significant promise, relevance and potential of widespread applicability in various industrial sectors such as aerospace, infrastructure and automotive. However, the adoption of this technology has been slower…

Machine Learning · Statistics 2020-06-16 Souvik Chakraborty , Sondipon Adhikari , Ranjan Ganguli

We live in a world of exploding complexity driven by technical evolution as well as highly volatile socio-economic environments. Managing complexity is a key issue in everyday decision making such as providing safe, sustainable, and…

Computers and Society · Computer Science 2023-11-28 Dirk Hartmann

With the accelerating availability of multimodal surgical data and real-time computation, Surgical Digital Twins (SDTs) have emerged as virtual counterparts that mirror, predict, and inform decisions across pre-, intra-, and postoperative…

Neural surrogates have shown great potential in simulating dynamical systems, while offering real-time capabilities. We envision Neural Twins as a progression of neural surrogates, aiming to create digital replicas of real systems. A neural…

Artificial Intelligence · Computer Science 2026-02-04 Andreas Radler , Vincent Seyfried , Johannes Brandstetter , Thomas Lichtenegger

Fully harvesting the gain of multiple-input and multiple-output (MIMO) requires accurate channel information. However, conventional channel acquisition methods mainly rely on pilot training signals, resulting in significant training…

Information Theory · Computer Science 2024-09-26 Shuaifeng Jiang , Qi Qu , Xiaqing Pan , Abhishek Agrawal , Richard Newcombe , Ahmed Alkhateeb

Digital Twins (DTs) are increasingly used as autonomous decision-makers in complex socio-technical systems. However, their mathematically optimal decisions often diverge from human expectations, revealing a persistent mismatch between…

Machine Learning · Computer Science 2025-12-10 Daniele Masti , Francesco Basciani , Arianna Fedeli , Girgio Gnecco , Francesco Smarra

Digital Twin technology creates virtual replicas of physical objects, processes, or systems by replicating their properties, data, and behaviors. This advanced technology offers a range of intelligent functionalities, such as modeling,…

Machine Learning · Computer Science 2024-08-26 Sagar Srinivas Sakhinana , Krishna Sai Sudhir Aripirala , Shivam Gupta , Venkataramana Runkana

Effective real-time monitoring is a foundation of digital twin technology, crucial for detecting material degradation and maintaining the structural integrity of nuclear systems to ensure both safety and operational efficiency. Traditional…

Machine Learning · Computer Science 2024-12-02 Raisa Bentay Hossain , Farid Ahmed , Kazuma Kobayashi , Seid Koric , Diab Abueidda , Syed Bahauddin Alam

Scientific Machine Learning (ML) is gaining momentum as a cost-effective alternative to physics-based numerical solvers in many engineering applications. In fact, scientific ML is currently being used to build accurate and efficient…

Machine Learning · Computer Science 2024-08-20 Matteo Salvador , Alison L. Marsden

A framework for creating and updating digital twins for dynamical systems from a library of physics-based functions is proposed. The sparse Bayesian machine learning is used to update and derive an interpretable expression for the digital…

Machine Learning · Statistics 2022-12-20 Tapas Tripura , Aarya Sheetal Desai , Sondipon Adhikari , Souvik Chakraborty

Surrogate models provide compact relations between user-defined input parameters and output quantities of interest, enabling the efficient evaluation of complex parametric systems in many-query settings. Such capabilities are essential in a…

Numerical Analysis · Mathematics 2026-03-16 Matteo Giacomini , Pedro Díez

Digital twins have emerged as a powerful technology for modeling and simulating complex systems across various domains (Fuller et al., 2020; Tao et al., 2019). As virtual representations of physical assets, processes, or systems, digital…

Software Engineering · Computer Science 2025-07-08 Gabriella Waters

Digital Twins (DTs) represent digital counterparts of physical systems, assets, or processes, referred to as the actual twin (AT). DTs integrate heterogeneous data, models, and semantic technologies to support monitoring, simulation,…

Software Engineering · Computer Science 2026-05-21 Faima Abbasi , Jean-Sébastien Sottet , Cedric Pruski

The Digital Twins (DT) has quickly become a hot topic since it was proposed. It not only appears in all kinds of commercial propaganda, but also is widely quoted by academic circles. However, there are misstatements and misuse of the term…

Computational Engineering, Finance, and Science · Computer Science 2022-03-25 Jiehan Zhou , Shouhua Zhang , Mu Gu

We introduce a novel digital twin framework for predictive maintenance of long-term physical systems. Using monitoring tire health as an application, we show how the digital twin framework can be used to enhance automotive safety and…

Machine Learning · Computer Science 2024-08-13 Vispi Karkaria , Jie Chen , Christopher Luey , Chase Siuta , Damien Lim , Robert Radulescu , Wei Chen