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We present a sequence-based probabilistic formalism that directly addresses co-operative effects in networks of interacting positions in proteins, providing significantly improved contact prediction, as well as accurate quantitative…

Quantitative Methods · Quantitative Biology 2012-07-12 Alan Lapedes , Bertrand Giraud , Christopher Jarzynski

Although the importance of protein dynamics in protein function is generally recognized, the role of protein fluctuations in allosteric effects scarcely has been considered. To address this gap, the Kullback-Leibler divergence (Dx) between…

Biomolecules · Quantitative Biology 2009-11-13 Michael E. Wall

Observations are reported in isothermal torsional oscillation tests on melts of isotactic polypropylene (iPP) and low-density polyethylene (LDPE) in the intervals of temperature between 190 and 250C (iPP) and between 120 and 190C (LDPE).…

Materials Science · Physics 2007-05-23 A. D. Drozdov , S. Agarwal , R. K. Gupta

A Boltzmann machine is a stochastic neural network that has been extensively used in the layers of deep architectures for modern machine learning applications. In this paper, we develop a Boltzmann machine that is capable of modelling…

Statistical Mechanics · Physics 2016-10-18 Giacomo Torlai , Roger G. Melko

We show that neural networks trained by evolutionary reinforcement learning can enact efficient molecular self-assembly protocols. Presented with molecular simulation trajectories, networks learn to change temperature and chemical potential…

Statistical Mechanics · Physics 2020-06-01 Stephen Whitelam , Isaac Tamblyn

Deformations of amorphous polymer networks prepared with significant concentrations of liquid crystalline mesogens have been recently reported to undergo mechanotropic phase transitions. Here, we report that these mechanotropic phase…

Soft Condensed Matter · Physics 2021-06-09 Jeremy A. Koch , Jeremy A. Herman , Timothy J. White

Societies are quintessential open systems, shaped by internal dynamics as well as external influences. The question is how these external influences alter the collective behavior and network dynamics. To answer this, we investigate…

Physics and Society · Physics 2026-05-11 S. Arab Mohammadi , H. Jafari , A. Kargaran , A. Hosseiny , G. Reza Jafari

Thermoelectric energy conversion is a direct but low-efficiency process, which precludes the development of long-awaited wide-scale applications. As a breakthrough permitting a drastic performance increase is seemingly out of reach, we…

Other Condensed Matter · Physics 2015-04-06 Henni Ouerdane , Andrey A. Varlamov , Alexey V. Kavokin , Christophe Goupil , Cronin B. Vining

The Cooperative Motion Algorithm is an efficient lattice method to simulate dense polymer systems and is often used with two different criteria to generate a Markov chain in the configuration space. While the first method is the…

Statistical Mechanics · Physics 2016-11-18 Piotr Knychala , Michal Banaszak

We discuss the structure and asymptotic long-time properties of coupled equations for the moments of a Brownian particle's momentum derived microscopically beyond the lowest approximation in the weak coupling parameter. Generalized…

Statistical Mechanics · Physics 2015-05-30 A. V. Plyukhin

We study the competition between thermal fluctuations and stress enhancement in the failure process of a disordered system by using a local load sharing fiber bundle model. The thermal noise is introduced by defining a failure probability…

Disordered Systems and Neural Networks · Physics 2021-02-24 Santanu Sinha , Subhadeep Roy , Alex Hansen

Two-state cooperativity is an important characteristic in protein folding. It is defined by a depletion of states lying energetically between folded and unfolded conformations. While there are different ways to test for two-state…

Biomolecules · Quantitative Biology 2015-05-28 Tristan Bereau , Markus Deserno , Michael Bachmann

Fluctuations are significant in mesoscopic systems and of particular importance in understanding quantum transport. Here, we show that fluctuations can be considered as a resource for the operations of open quantum systems as functional…

Mesoscale and Nanoscale Physics · Physics 2020-09-16 Jincheng Lu , Rongqian Wang , Chen Wang , Jian-Hua Jiang

The estimation and management of motor temperature are important for the continuous movements of robots. In this study, we propose an online learning method of thermal model parameters of motors for an accurate estimation of motor core…

We present the design for a thermodynamic computer that can perform arbitrary nonlinear calculations in or out of equilibrium. Simple thermodynamic circuits, fluctuating degrees of freedom in contact with a thermal bath and confined by a…

Statistical Mechanics · Physics 2026-01-08 Stephen Whitelam , Corneel Casert

Allostery plays a fundament role in most biological processes. However, little theory is available to describe it outside of two-state models. Here we use a statistical mechanical approach to show that the allosteric coupling between two…

Biological Physics · Physics 2017-04-05 Michel A. Cuendet , Harel Weinstein , Michael V. LeVine

Cytoskeletal filaments are capable of self-assembly in the absence of externally supplied chemical energy, but the rapid turnover rates essential for their biological function require a constant flux of ATP or GTP hydrolysis. The same is…

Biological Physics · Physics 2019-08-26 Robert Marsland , Jeremy England

A successful deep learning network is highly dependent not only on the training dataset, but the training algorithm used to condition the network for a given task. The loss function, dataset, and tuning of hyperparameters all play an…

Machine Learning · Computer Science 2025-10-07 Ashley Lenau , Dennis Dimiduk , Stephen R. Niezgoda

Heat fluctuations of a harmonic oscillator in contact with a thermostat and driven out of equilibrium by an external deterministic force are studied experimentally and theoretically within the context of Fluctuation Theorems. We consider…

Statistical Mechanics · Physics 2007-05-23 Sylvain Joubaud , Nicolas B. Garnier , Sergio Ciliberto

Temperature compensation is a notable property of circadian oscillators that indicates the insensitivity of the oscillator system's period to temperature changes; the underlying mechanism, however, is still unclear. We investigated the…

Biological Physics · Physics 2015-06-24 Yuanyuan Peng , Yoshihiko Hasegawa , Nasimul Noman , Hitoshi Iba
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