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The concept of chemical bonding is a crucial aspect of chemistry that aids in understanding the complexity and reactivity of molecules and materials. However, the interpretation of chemical bonds can be hindered by the choice of the…

Computational Physics · Physics 2024-01-09 Toni Oestereich , Ralf Tonner-Zech , Julia Westermayr

Energy decomposition analysis (EDA) based on absolutely localized molecular orbitals (ALMOs) decomposes the interaction energy between molecules into physically interpretable components like geometry distortion, frozen interactions,…

Chemical Physics · Physics 2021-07-19 Srimukh Prasad Veccham , Joonho Lee , Yuezhi Mao , Paul R. Horn , Martin Head-Gordon

The development and first applications of a new periodic energy decomposition analysis (pEDA) scheme for extended systems based on the Kohn-Sham approach to density functional theory are described. The pEDA decomposes the binding energy…

Chemical Physics · Physics 2015-05-19 Marc Raupach , Ralf Tonner

We apply a number of atomic decomposition schemes across the standard QM7 dataset -- a small model set of organic molecules at equilibrium geometry -- to inspect the possible emergence of trends among contributions to atomization energies…

Chemical Physics · Physics 2023-04-19 Frederik Ø. Kjeldal , Janus J. Eriksen

We introduce a local machine-learning method for predicting the electron densities of periodic systems. The framework is based on a numerical, atom-centred auxiliary basis, which enables an accurate expansion of the all-electron density in…

Chemical Physics · Physics 2021-11-10 Alan M. Lewis , Andrea Grisafi , Michele Ceriotti , Mariana Rossi

We propose a descriptor for molecular electronic structure that is based solely on the one- and two-electron integrals but is translationally, rotationally, and unitarily invariant. Then, directly exploiting size consistency, we train and…

Quantum Physics · Physics 2026-03-02 Valerii Chuiko , Giovanni B. Da Rosa , Paul W. Ayers

Electrodermal activity (EDA) is widely used in wearable Internet of Medical Things (IoMT) systems for continuous health monitoring, including autonomic assessment. However, EDA signals are highly vulnerable to motion artifacts and…

Signal Processing · Electrical Eng. & Systems 2026-05-08 Yongbin Lee , Andrew Peitzsch , Youngsun Kong , Jarod Zizza , Dong-hee Kang , Farnoush Baghestani , Ki H. Chon

We study alchemical atomic energy partitioning as a method to estimate atomisation energies from atomic contributions which are defined in physically rigorous and general ways through use of the uniform electron gas as a joint reference. We…

We present a novel energy-based localization procedure able to localize molecular orbitals into specific spatial regions. The method is applied to several cases including both conjugated and non-conjugated systems. The obtained localized…

Chemical Physics · Physics 2022-09-13 Tommaso Giovannini , Henrik Koch

Determining the aqueous solubility of molecules is a vital step in many pharmaceutical, environmental, and energy storage applications. Despite efforts made over decades, there are still challenges associated with developing a solubility…

Materials Science · Physics 2022-09-05 Gihan Panapitiya , Michael Girard , Aaron Hollas , Vijay Murugesan , Wei Wang , Emily Saldanha

Path-integral molecular dynamics simulations and electronic structure-based energy decomposition analysis (EDA) are employed to connect hydrogen bond (H-bond) strength, its asymmetry, and the total delocalization energy at the water/air…

Chemical Physics · Physics 2026-02-03 Frederik Zysk , Ana Vila Verde , Naveen K. Kaliannan , Kristof Karhan , Thomas D. Kühne

The electronic charge density plays a central role in determining the behavior of matter at the atomic scale, but its computational evaluation requires demanding electronic-structure calculations. We introduce an atom-centered,…

Chemical bonding is a ubiquitous concept in chemistry and it provides a common basis for experimental and theoretical chemists to explain and predict the structure, stability and reactivity of chemical species. Among others, the Energy…

This work constructs an advanced force field, the Completely Multipolar Model (CMM), to quantitatively reproduce each term of an energy decomposition analysis (EDA) for aqueous solvated alkali metal cations and halide anions and their ion…

Chemical Physics · Physics 2024-10-14 J. P. Heindel , L. Kim , M. Head-Gordon , T. Head-Gordon

The electron density of a molecule or material has recently received major attention as a target quantity of machine-learning models. A natural choice to construct a model that yields transferable and linear-scaling predictions is to…

Chemical Physics · Physics 2022-06-29 Andrea Grisafi , Alan M. Lewis , Mariana Rossi , Michele Ceriotti

Existing molecular machine learning force fields (MLFFs) generally focus on the learning of atoms, molecules, and simple quantum chemical properties (such as energy and force), but ignore the importance of electron density (ED) $\rho(r)$ in…

Chemical Physics · Physics 2025-09-25 Hongxin Xiang , Ke Li , Mingquan Liu , Zhixiang Cheng , Bin Yao , Wenjie Du , Jun Xia , Li Zeng , Xin Jin , Xiangxiang Zeng

The calculation of thermodynamic properties of biochemical systems typically requires the use of resource-intensive molecular simulation methods. One example thereof is the thermodynamic profiling of hydration sites, i.e. high-probability…

Biomolecules · Quantitative Biology 2020-01-08 Ahmadreza Ghanbarpour , Amr H. Mahmoud , Markus A. Lill

We present the Electronic Tensor Reconstruction Algorithm (ELECTRA) - an equivariant model for predicting electronic charge densities using floating orbitals. Floating orbitals are a long-standing concept in the quantum chemistry community…

Machine Learning · Computer Science 2026-01-27 Jonas Elsborg , Luca Thiede , Alán Aspuru-Guzik , Tejs Vegge , Arghya Bhowmik

We develop a machine-learning framework to predict the electron localization function (ELF) of pure, dense hydrogen directly from atomic geometry, bypassing explicit electronic-structure calculations. Trained on first-principles data…

Time-dependent partial differential equations (PDEs) for classic physical systems are established based on the conservation of mass, momentum, and energy, which are ubiquitous in scientific and engineering applications. These PDEs are…

Machine Learning · Computer Science 2025-01-14 Jiangce Chen , Wenzhuo Xu , Zeda Xu , Noelia Grande Gutiérrez , Sneha Prabha Narra , Christopher McComb
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