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PET image reconstruction is challenging due to the ill-poseness of the inverse problem and limited number of detected photons. Recently deep neural networks have been widely and successfully used in computer vision tasks and attracted…

Computer Vision and Pattern Recognition · Computer Science 2017-10-11 Kuang Gong , Jiahui Guan , Kyungsang Kim , Xuezhu Zhang , Georges El Fakhri , Jinyi Qi , Quanzheng Li

As PET imaging is accompanied by substantial radiation exposure and cancer risk, reducing radiation dose in PET scans is an important topic. However, low-count PET scans often suffer from high image noise, which can negatively impact image…

Image and Video Processing · Electrical Eng. & Systems 2023-05-01 Huidong Xie , Qiong Liu , Bo Zhou , Xiongchao Chen , Xueqi Guo , Chi Liu

Low-dose Positron Emission Tomography (PET) imaging presents a significant challenge due to increased noise and reduced image quality, which can compromise its diagnostic accuracy and clinical utility. Denoising diffusion probabilistic…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Boxiao Yu , Savas Ozdemir , Jiong Wu , Yizhou Chen , Ruogu Fang , Kuangyu Shi , Kuang Gong

Three-dimensional (3D) medical image enhancement, including denoising and super-resolution, is critical for clinical diagnosis in CT, PET, and MRI. Although diffusion models have shown remarkable success in 2D medical imaging, scaling them…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Hongxu Jiang , Fei Li , Boxiao Yu , Ying Zhang , Kaleb Smith , Kuang Gong , Wei Shao

Despite the indispensable role of X-ray computed tomography (CT) in diagnostic medicine field, the associated ionizing radiation is still a major concern considering that it may cause genetic and cancerous diseases. Decreasing the exposure…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Ti Bai , Dan Nguyen , Biling Wang , Steve Jiang

In spectroscopic experiments, data acquisition in multi-dimensional phase space may require long acquisition time, owing to the large phase space volume to be covered. In such case, the limited time available for data acquisition can be a…

Deep neural networks have a great potential to improve image denoising in low-dose computed tomography (LDCT). Popular ways to increase the network capacity include adding more layers or repeating a modularized clone model in a sequence. In…

Image and Video Processing · Electrical Eng. & Systems 2020-05-15 Siqi Li , Guobao Wang

Positron Emission Tomography (PET) is a functional imaging modality that enables the visualization of biochemical and physiological processes across various tissues. Recently, deep learning (DL)-based methods have demonstrated significant…

Image and Video Processing · Electrical Eng. & Systems 2026-01-16 Yiran Sun , Osama Mawlawi

Position emission tomography (PET) is widely used in clinics and research due to its quantitative merits and high sensitivity, but suffers from low signal-to-noise ratio (SNR). Recently convolutional neural networks (CNNs) have been widely…

Image and Video Processing · Electrical Eng. & Systems 2023-12-12 Se-In Jang , Tinsu Pan , Ye Li , Pedram Heidari , Junyu Chen , Quanzheng Li , Kuang Gong

Parametric images provide insight into the spatial distribution of physiological parameters, but they are often extremely noisy, due to low SNR of tomographic data. Direct estimation from projections allows accurate noise modeling,…

Image convolution with complex kernels is a fundamental operation in photography, scientific imaging, and animation effects, yet direct dense convolution is computationally prohibitive on resource-limited devices. Existing approximations,…

Graphics · Computer Science 2026-05-20 Zhizhen Wu , Zhe Cao , Yuchi Huo

Positron Emission Tomography (PET) imaging is a vital tool in medical diagnostics, offering detailed insights into molecular processes within the human body. However, PET images often suffer from complicated noise, which can obscure…

Computer Vision and Pattern Recognition · Computer Science 2026-01-30 Xuehua Ye , Hongxu Yang , Adam J. Schwarz

Low-dose CT has been a key diagnostic imaging modality to reduce the potential risk of radiation overdose to patient health. Despite recent advances, CNN-based approaches typically apply filters in a spatially invariant way and adopt…

Image and Video Processing · Electrical Eng. & Systems 2021-07-27 Lu Xu , Yuwei Zhang , Ying Liu , Daoye Wang , Mu Zhou , Jimmy Ren , Jingwei Wei , Zhaoxiang Ye

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…

Medical Physics · Physics 2026-03-18 George Webber , Alexander Hammers , Andrew P King , Andrew J Reader

Most of the classical denoising methods restore clear results by selecting and averaging pixels in the noisy input. Instead of relying on hand-crafted selecting and averaging strategies, we propose to explicitly learn this process with deep…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Xiangyu Xu , Muchen Li , Wenxiu Sun

Reconstruction of PET images is an ill-posed inverse problem and often requires iterative algorithms to achieve good image quality for reliable clinical use in practice, at huge computational costs. In this paper, we consider the PET…

Computer Vision and Pattern Recognition · Computer Science 2017-04-25 Jieqing Jiao , Sebastien Ourselin

Dynamic positron emission tomography (PET) reconstruction often presents high noise due to the use of short duration frames to describe the kinetics of the radiotracer. Here we introduce a new method to calculate a kernel matrix to be used…

Medical Physics · Physics 2026-01-01 Alan Miranda , Steven Staelens

Increasing use of CT in modern medical practice has raised concerns over associated radiation dose. Reduction of radiation dose associated with CT can increase noise and artifacts, which can adversely affect diagnostic confidence. Denoising…

Computer Vision and Pattern Recognition · Computer Science 2017-02-24 Qingsong Yang , Pingkun Yan , Mannudeep K. Kalra , Ge Wang

Recently, tremendous human-designed and automatically searched neural networks have been applied to image denoising. However, previous works intend to handle all noisy images in a pre-defined static network architecture, which inevitably…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Zutao Jiang , Changlin Li , Xiaojun Chang , Jihua Zhu , Yi Yang

A deep convolutional neural network has been developed to denoise atomic-resolution TEM image datasets of nanoparticles acquired using direct electron counting detectors, for applications where the image signal is severely limited by shot…