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The availability of large-scale neuronal population datasets necessitates new methods to model population dynamics and extract interpretable, scientifically translatable insights. Existing deep learning methods often overlook the biological…

Neurons and Cognition · Quantitative Biology 2024-11-14 Parsa Delavari , Ipek Oruc , Timothy H Murphy

Recent work in reinforcement learning has shown that incorporating structural priors for articulated robots, such as link connectivity, into policy networks improves learning efficiency. However, dynamics properties, despite their…

Robotics · Computer Science 2026-03-24 Sangwoo Shin , Kunzhao Ren , Xiaobin Xiong , Josiah P. Hanna

Conventional deep learning prioritizes unconstrained optimization, yet biological systems operate under strict metabolic constraints. We propose that these physical constraints shape dynamics to function not as limitations, but as a…

Machine Learning · Computer Science 2026-01-23 Xia Chen

We describe a framework that can integrate prior physical information, e.g., the presence of kinematic constraints, to support data-driven simulation in multi-body dynamics. Unlike other approaches, e.g., Fully-connected Neural Network…

Computational Engineering, Finance, and Science · Computer Science 2024-07-12 Jingquan Wang , Shu Wang , Huzaifa Mustafa Unjhawala , Jinlong Wu , Dan Negrut

Neural population activity relating to behaviour is assumed to be inherently low-dimensional despite the observed high dimensionality of data recorded using multi-electrode arrays. Therefore, predicting behaviour from neural population…

Neurons and Cognition · Quantitative Biology 2022-02-17 Justin Jude , Matthew G Perich , Lee E Miller , Matthias H Hennig

An effective way to achieve intelligence is to simulate various intelligent behaviors in the human brain. In recent years, bio-inspired learning methods have emerged, and they are different from the classical mathematical programming…

Artificial Intelligence · Computer Science 2019-04-01 Jieneng Chen , Jingye Chen , Ruiming Zhang , Xiaobin Hu

Deep artificial neural networks famously struggle to learn from non-stationary streams of data. Without dedicated mitigation strategies, continual learning is associated with continuous forgetting of previous tasks and a progressive loss of…

Neurons and Cognition · Quantitative Biology 2025-12-29 Suzanne van der Veldt , Gido M. van de Ven , Sanne Moorman , Guillaume Etter

Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying dynamics of biological systems from sparse experimental data. In the present work, BINNs…

Quantitative Methods · Quantitative Biology 2021-01-27 John H. Lagergren , John T. Nardini , Ruth E. Baker , Matthew J. Simpson , Kevin B. Flores

Advancements in artificial intelligence call for a deeper understanding of the fundamental mechanisms underlying deep learning. In this work, we propose a theoretical framework to analyze learning dynamics through the lens of dynamical…

Machine Learning · Computer Science 2025-10-13 Yuchen Lin , Yong Zhang , Sihan Feng , Hong Zhao

AI-driven design problems, such as DNA/protein sequence design, are commonly tackled from two angles: generative modeling, which efficiently captures the feasible design space (e.g., natural images or biological sequences), and model-based…

Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative…

Recent achievements in implantable brain-computer interfaces (iBCIs) have demonstrated the potential to decode cognitive and motor behaviors with intracranial brain recordings; however, individual physiological and electrode implantation…

Neurons and Cognition · Quantitative Biology 2025-06-17 Di Wu , Linghao Bu , Yifei Jia , Lu Cao , Siyuan Li , Siyu Chen , Yueqian Zhou , Sheng Fan , Wenjie Ren , Dengchang Wu , Kang Wang , Yue Zhang , Yuehui Ma , Jie Yang , Mohamad Sawan

Finding an appropriate representation of dynamic activities in the brain is crucial for many downstream applications. Due to its highly dynamic nature, temporally averaged fMRI (functional magnetic resonance imaging) can only provide a…

Machine Learning · Computer Science 2022-08-18 Sikun Lin , Shuyun Tang , Scott Grafton , Ambuj Singh

Latent dynamics models have emerged as powerful tools for modeling and interpreting neural population activity. Recently, there has been a focus on incorporating simultaneously measured behaviour into these models to further disentangle…

Neurons and Cognition · Quantitative Biology 2021-10-29 Cole Hurwitz , Akash Srivastava , Kai Xu , Justin Jude , Matthew G. Perich , Lee E. Miller , Matthias H. Hennig

Traditional symbolic reasoning engines, while attractive for their precision and explicability, have a few major drawbacks: the use of brittle inference procedures that rely on exact matching (unification) of logical terms, an inability to…

Computation and Language · Computer Science 2021-12-07 Aditya Kalyanpur , Tom Breloff , David Ferrucci

This paper studies the coupling of internally guided learning and social interaction, and more specifically the improvement owing to demonstrations of the learning by intrinsic motivation. We present Socially Guided Intrinsic Motivation by…

Machine Learning · Computer Science 2019-02-01 Sao Mai Nguyen , Adrien Baranes , Pierre-Yves Oudeyer

We propose to use a simulation driven inverse inference approach to model the dynamics of tree branches under manipulation. Learning branch dynamics and gaining the ability to manipulate deformable vegetation can help with occlusion-prone…

Robotics · Computer Science 2023-12-21 Jayadeep Jacob , Tirthankar Bandyopadhyay , Jason Williams , Paulo Borges , Fabio Ramos

Neural population activity is theorized to reflect an underlying dynamical structure. This structure can be accurately captured using state space models with explicit dynamics, such as those based on recurrent neural networks (RNNs).…

Neurons and Cognition · Quantitative Biology 2023-07-21 Joel Ye , Chethan Pandarinath

The discovery of governing equations from data has been an active field of research for decades. One widely used methodology for this purpose is sparse regression for nonlinear dynamics, known as SINDy. Despite several attempts, noisy and…

Dynamical Systems · Mathematics 2023-09-15 Ali Forootani , Pawan Goyal , Peter Benner

We present a novel methodology for control of neural circuits based on deep reinforcement learning. Our approach achieves aimed behavior by generating external continuous stimulation of existing neural circuits (neuromodulation control) or…

Neurons and Cognition · Quantitative Biology 2020-06-15 Jimin Kim , Eli Shlizerman