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Purpose: CBCT-based adaptive radiotherapy requires daily images for accurate dose calculations. This study investigates the feasibility of applying a single convolutional network to facilitate CBCT-to-CT synthesis for head-and-neck, lung,…

An MRI-only adaptive radiotherapy (ART) workflow is desirable for managing interfractional changes in anatomy, but producing synthetic CT (sCT) data through paired data-driven deep learning (DL) for abdominal dose calculations remains a…

The generation of synthetic CT (sCT) images from cone-beam CT (CBCT) data using deep learning methodologies represents a significant advancement in radiation oncology. This systematic review, following PRISMA guidelines and using the PICO…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Alzahra Altalib , Scott McGregor , Chunhui Li , Alessandro Perelli

Radiation therapy (RT) requires precise dose delivery over multiple fractions, with CT fundamental for treatment planning due to its electron density information. Repeated CT acquisitions impose radiation exposure and logistical burdens,…

To enable magnetic resonance (MR)-only radiotherapy and facilitate modelling of radiation attenuation in humans, synthetic-CT (sCT) images need to be generated. Considering the application of MR-guided radiotherapy and online adaptive…

Purpose: This study assesses the effectiveness of Deep Learning (DL) for creating synthetic CT (sCT) images in MR-guided adaptive radiation therapy (MRgART). Methods: A Cycle-GAN model was trained with MRI and CT scan slices from MR-LINAC…

Purpose: Organ-at-risk (OAR) delineation is a key step for cone-beam CT (CBCT) based adaptive radiotherapy planning that can be a time-consuming, labor-intensive, and subject-to-variability process. We aim to develop a fully automated…

Accurate dose calculations in proton therapy rely on high-quality CT images. While planning CTs (pCTs) serve as a reference for dosimetric planning, Cone Beam CT (CBCT) is used throughout Adaptive Radiotherapy (ART) to generate sCTs for…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 David Vallmanya Poch , Yorick Estievenart , Elnura Zhalieva , Sukanya Patra , Mohammad Yaqub , Souhaib Ben Taieb

Proton computed tomography (pCT) is a novel medical imaging modality for mapping the distribution of proton relative stopping power (RSP) in medical objects of interest. Compared to conventional X-ray computed tomography, where range…

Purpose: To evaluate reliability of upright CT for proton dose calculation and feasibility of a simplified phantom configuration for accelerated routine QA. Methods: A calibration phantom was scanned on an upright CT following consensus…

Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…

Cone-Beam Computed Tomography (CBCT) is widely used for real-time intraoperative imaging due to its low radiation dose and high acquisition speed. However, despite its high resolution, CBCT suffers from significant artifacts and thereby…

Image and Video Processing · Electrical Eng. & Systems 2025-06-11 Maximilian Tschuchnig , Lukas Lamminger , Philipp Steininger , Michael Gadermayr

Objective: Machine learning (ML) based radiation treatment (RT) planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising importance of Magnetic resonance (MR) only treatment planning…

Medical Physics · Physics 2022-06-13 Aly Khalifa , Jeff Winter , Inmaculada Navarro , Chris McIntosh , Thomas G. Purdie

Image synthesis is used to generate synthetic CTs (sCTs) from on-treatment cone-beam CTs (CBCTs) with a view to improving image quality and enabling accurate dose computation to facilitate a CBCT-based adaptive radiotherapy workflow. As…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Chelsea A. H. Sargeant , Edward G. A. Henderson , Dónal M. McSweeney , Aaron G. Rankin , Denis Page

Purpose: Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased interest in public…

Cone beam computed tomography (CBCT) images can be used for dose calculation in adaptive radiation therapy (ART). The main challenges are the large artefacts and inaccurate Hounsfield unit (HU) values. Currently, deformed planning CT images…

Medical Physics · Physics 2019-09-04 Xiao Liang , Liyuan Chen , Dan Nguyen , Zhiguo Zhou , Xuejun Gu , Ming Yang , Jing Wang , Steve Jiang

Personalized computed tomography (CT) dosimetry has great potential in assessing patient-specific radiation exposure, supporting risk assessment, and optimizing clinical protocols. The aim of this study is to evaluate the potential of…

Medical Physics · Physics 2026-01-15 Marie-Luise Kuhlmann , Jörg Martin , Stefan Pojtinger

Background: Cone-beam computed tomography (CBCT) scans, performed fractionally (e.g., daily or weekly), are widely utilized for patient alignment in the image-guided radiotherapy (IGRT) process, thereby making it a potential imaging…

Purpose: This study assessed the dosimetric accuracy of synthetic CT images generated from magnetic resonance imaging (MRI) data for focal brain radiation therapy, using a deep learning approach. Material and Methods: We conducted a study…

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