English
Related papers

Related papers: Efficient Quantum Protein Structure Prediction wit…

200 papers

Quantum computers offer the potential to simulate nuclear processes that are classically intractable. With the goal of understanding the necessary quantum resources to realize this potential, we employ state-of-the-art…

We study the protein folding problem on the base of the quantum approach we proposed recently by considering the model of protein chain with nine amino-acid residues. We introduced the concept of distance space and its projections on a…

Biological Physics · Physics 2021-06-24 Wen-Wen Mao , Li-Hua Lu , Yong-Yun Ji , You-Quan Li

Quantum Machine Learning (QML) holds the promise of enhancing machine learning modeling in terms of both complexity and accuracy. A key challenge in this domain is the encoding of input data, which plays a pivotal role in determining the…

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

Quantum convolutional neural networks (QCNNs) represent a promising approach in quantum machine learning, paving new directions for both quantum and classical data analysis. This approach is particularly attractive due to the absence of the…

Quantum Physics · Physics 2025-08-06 Changwon Lee , Israel F. Araujo , Dongha Kim , Junghan Lee , Siheon Park , Ju-Young Ryu , Daniel K. Park

Noise is the central obstacle to building large-scale quantum computers. Quantum systems with sufficiently uncorrelated and weak noise could be used to solve computational problems that are intractable with current digital computers. There…

Quantum Physics · Physics 2021-04-19 Robin Harper , Steven T. Flammia , Joel J. Wallman

Improving the efficiency and accuracy of energy calculations has been of significant and continued interest in the area of materials informatics, a field that applies machine learning techniques to computational materials data. Here, we…

Quantum Physics · Physics 2021-02-03 Tanvi P. Gujarati , Tyler Takeshita , Andreas Hintennach , Eunseok Lee

Characterizing thermally activated transitions in high-dimensional rugged energy surfaces is a very challenging task for classical computers. Here, we develop a quantum annealing scheme to solve this problem. First, the task of finding the…

Quantum Physics · Physics 2021-01-18 Philipp Hauke , Giovanni Mattiotti , Pietro Faccioli

Over the last century, a large number of physical and mathematical developments paired with rapidly advancing technology have allowed the field of quantum chemistry to advance dramatically. However, the lack of computationally efficient…

Quantum Physics · Physics 2011-03-08 James D. Whitfield , Jacob Biamonte , Alán Aspuru-Guzik

Quantum computers have the potential to revolutionise our understanding of the microscopic behaviour of materials and chemical processes by enabling high-accuracy electronic structure calculations to scale more efficiently than is possible…

Quantum Physics · Physics 2025-04-08 Manolo C. Per , Nathan Rhodes , Maiyuren Srikumar , Joshua W. Dai

We make the case that variational algorithm ansatzes for near-term quantum computing are well-suited for the quantum circuit cutting strategy. Previous demonstrations of circuit cutting focused on the exponential execution and…

Quantum Physics · Physics 2024-12-25 Zirui Li , Minghao Guo , Mayank Barad , Wei Tang , Eddy Z. Zhang , Yipeng Huang

In machine learning, fewer features reduce model complexity. Carefully assessing the influence of each input feature on the model quality is therefore a crucial preprocessing step. We propose a novel feature selection algorithm based on a…

Quantum Physics · Physics 2023-02-22 Sascha Mücke , Raoul Heese , Sabine Müller , Moritz Wolter , Nico Piatkowski

Quantum computing can empower machine learning models by enabling kernel machines to leverage quantum kernels for representing similarity measures between data. Quantum kernels are able to capture relationships in the data that are not…

Tailoring the functional properties of advanced organic/inorganic heterogeonous devices to their intended technological applications requires knowledge and control of the microscopic structure inside the device. Atomistic quantum mechanical…

Materials Science · Physics 2019-03-13 Milica Todorović , Michael U. Gutmann , Jukka Corander , Patrick Rinke

The prediction of the three-dimensional structures of the native state of proteins from the sequences of their amino acids is one of the most important challenges in molecular biology. An essential ingredient to solve this problem within…

Statistical Mechanics · Physics 2007-05-23 Cristian Micheletti , Flavio Seno , Jayanth Banavar , Amos Maritan

Many computer vision applications need to recover structure from imperfect measurements of the real world. The task is often solved by robustly fitting a geometric model onto noisy and outlier-contaminated data. However, recent theoretical…

Computer Vision and Pattern Recognition · Computer Science 2020-10-12 Tat-Jun Chin , David Suter , Shin-Fang Chng , James Quach

Quantum chemistry is one of the most promising applications of quantum computers in the near future. For noisy intermediate-scale quantum devices, the quantum-classical hybrid framework based on the variational quantum eigensolver (VQE) has…

Within machine learning model evaluation regimes, feature selection is a technique to reduce model complexity and improve model performance in regards to generalization, model fit, and accuracy of prediction. However, the search over the…

Machine Learning · Computer Science 2021-05-19 David Von Dollen , Florian Neukart , Daniel Weimer , Thomas Bäck

Recent years have witnessed a surge in the development of protein structural tokenization methods, which chunk protein 3D structures into discrete or continuous representations. Structure tokenization enables the direct application of…

Quantitative Methods · Quantitative Biology 2025-06-26 Xinyu Yuan , Zichen Wang , Marcus Collins , Huzefa Rangwala

Recently developed quantum algorithms suggest that quantum computers can solve certain problems and perform certain tasks more efficiently than conventional computers. Among other reasons, this is due to the possibility of creating…

Quantum Physics · Physics 2007-05-23 Rolando D. Somma