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Biophotonics is an active research area in molecular imaging, genetic diagnosis and prognosis, with direct applicability in precision medicine. However, long-standing challenges of biophotonics are well known due to low signal-to-noise…

Medical Physics · Physics 2017-10-02 Michael C Lun , Wei Zhang , Yue Zhao , Jeffrey Anker , Wenxiang Cong , Ge Wang , Changqing Li

Medical images come in high resolutions. A high resolution is vital for finding malignant tissues at an early stage. Yet, this resolution presents a challenge in terms of modeling long range dependencies. Shallow transformers eliminate this…

Computer Vision and Pattern Recognition · Computer Science 2022-08-15 Ahmed Taha , Yen Nhi Truong Vu , Brent Mombourquette , Thomas Paul Matthews , Jason Su , Sadanand Singh

This paper strives to generate a synthetic computed tomography (CT) image from a magnetic resonance (MR) image. The synthetic CT image is valuable for radiotherapy planning when only an MR image is available. Recent approaches have made…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Zenglin Shi , Pascal Mettes , Guoyan Zheng , Cees Snoek

We propose approaches based on deep learning to localize objects in images when only a small training dataset is available and the images have low quality. That applies to many problems in medical image processing, and in particular to the…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Aaron Pries , Peter J. Schreier , Artur Lamm , Stefan Pede , Jürgen Schmidt

There is a growing interest to get a fully MR based radiotherapy. The most important development needed is to obtain improved bone tissue estimation. The existing model-based methods perform poorly on bone tissues. This paper was aimed at…

Applications · Statistics 2019-04-02 Fekadu L. Bayisa , Jun Yu

We propose a 3D neural network with specific loss functions for quantitative computed tomography (QCT) noise reduction to compute micro-structural parameters such as tissue mineral density (TMD) and bone volume ratio (BV/TV) with…

Image and Video Processing · Electrical Eng. & Systems 2020-11-11 Felix Thomsen , José M. Fuertes García , Manuel Lucena , Juan Pisula , Rodrigo de Luis García , Jan Broggrefe , Claudio Delrieux

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in…

Existing medical image super-resolution methods rely on pairs of low- and high- resolution images to learn a mapping in a fully supervised manner. However, such image pairs are often not available in clinical practice. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2021-02-08 Hongwei Li , Rameshwara G. N. Prasad , Anjany Sekuboyina , Chen Niu , Siwei Bai , Werner Hemmert , Bjoern Menze

Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in-vivo OCT imaging of a live mouse using wavefront shaping to enhance the penetration depth. A digital micro-mirror…

Magnetic resonance imaging (MRI) is the non-invasive modality of choice for body tissue composition analysis due to its excellent soft tissue contrast and lack of ionizing radiation. However, quantification of body composition requires an…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Ismail Irmakci , Sarfaraz Hussein , Aydogan Savran , Rita R. Kalyani , David Reiter , Chee W. Chia , Kenneth W. Fishbein , Richard G. Spencer , Luigi Ferrucci , Ulas Bagci

While micro-CT systems are instrumental in preclinical research, clinical micro-CT imaging has long been desired with cochlear implantation as a primary example. The structural details of the cochlear implant and the temporal bone require a…

Bones are always wrapped by soft tissues. As a result, bones in their X-ray images are obscured and become unclear. In this paper, we tackle this problem and propose a novel task to virtually decompose the soft tissue and bone by image…

Image and Video Processing · Electrical Eng. & Systems 2020-07-30 Yuanhao Gong

X-ray fluorescence computed tomography (XFCT) is a molecular imaging technique of x-ray photons, which can be used to sense different elements or nanoparticle (NP) agents inside deep samples or tissues. XFCT has been an active research…

Medical Physics · Physics 2021-02-01 Ignacio O. Romero , Yile Fang , Michael Lun , Changqing Li

The cost-effectiveness and practical harmlessness of ultrasound imaging have made it one of the most widespread tools for medical diagnosis. Unfortunately, the beam-forming based image formation produces granular speckle noise, blurring,…

Computer Vision and Pattern Recognition · Computer Science 2017-10-19 Sanketh Vedula , Ortal Senouf , Alex M. Bronstein , Oleg V. Michailovich , Michael Zibulevsky

Medical Imagings are considered one of the crucial diagnostic tools for different bones-related diseases, especially bones fractures. This paper investigates the robustness of pre-trained deep learning models for classifying bone fractures…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Robby Hoover , Nelly Elsayed , Zag ElSayed , Chengcheng Li

Ultrasound imaging of the cortex of long bones may enable the measurement of the cortical thickness and the ultrasound wave speed in cortical bone tissue. However, with bone loss, the cortical porosity and the size of the pores increase,…

Medical Physics · Physics 2025-07-14 Amadou S. Dia , Quentin Grimal , Guillaume Renaud

Background Computer-based geometrical meshes of bones are important for applications in computational biomechanics as well as clinical software. There is however a lack of freely available detailed bone meshes, especially related to the…

Tissues and Organs · Quantitative Biology 2018-07-16 Manish Sreenivasa , Daniel Gonzalez-Alvarado

The diagnosis of primary bone tumors is challenging, as the initial complaints are often non-specific. Early detection of bone cancer is crucial for a favorable prognosis. Incidentally, lesions may be found on radiographs obtained for other…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Tal Zimbalist , Ronnie Rosen , Keren Peri-Hanania , Yaron Caspi , Bar Rinott , Carmel Zeltser-Dekel , Eyal Bercovich , Yonina C. Eldar , Shai Bagon

Over the past decade, reflection matrix microscopy (RMM) and advanced image reconstruction algorithms have emerged to address the fundamental imaging depth limitations of optical microscopy in thick biological tissues and complex media. In…

Optics · Physics 2024-07-03 Sungsam Kang , Seokchan Yoon , Wonshik Choi

Cortical thickness measurements from magnetic resonance imaging, an important biomarker in many neurodegenerative and neurological disorders, are derived by many tools from an initial voxel-wise tissue segmentation. White matter (WM)…

Image and Video Processing · Electrical Eng. & Systems 2025-03-27 Vinzenz Uhr , Ivan Diaz , Christian Rummel , Richard McKinley
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