Related papers: Magnetically Guided Endothelial BioBots: A Next-Ge…
Currently, strokes are the leading cause of adult disability in the United States. Traditional treatment and rehabilitation options such as physical therapy and tissue plasminogen activator are limited in their effectiveness and ability to…
While we are making progress in overcoming infectious diseases and cancer; one of the major medical challenges of the mid-21st century will be the rising prevalence of stroke. Large vessels occlusions are especially debilitating, yet…
Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm…
Soft robotic instruments could navigate delicate, tortuous anatomy more safely than rigid tools, but clinical adoption is limited by insufficient tip functionalization and real-time feedback at the tissue interface. Few sensing and…
To address the issues that arise due to the manual navigation of guidewires in endovascular interventions, research in medical robotics has taken a strong interest in developing robotically steerable guidewires, which offer the possibility…
Artificial microswimmers are a new technology with promising microfluidics and biomedical applications, such as directed cargo transport, microscale assembly, and targeted drug delivery. A fundamental barrier to realising this potential is…
Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, DNA sequencing, and other laboratory procedures involving molecular biology. Most microfluidic biochips are based on the principle of continuous fluid flow…
Intracranial aneurysms (IAs) are abnormal dilations of cerebral blood vessels that, if ruptured, can lead to life-threatening consequences. However, their small size and soft contrast in radiological scans often make it difficult to perform…
Accurate identification and quantification of unruptured intracranial aneurysms (UIAs) is crucial for the risk assessment and treatment of this cerebrovascular disorder. Current 2D manual assessment on 3D magnetic resonance angiography…
In situ tissue biopsy with an endoluminal catheter is an efficient approach for disease diagnosis, featuring low invasiveness and few complications. However, the endoluminal catheter struggles to adjust the biopsy direction by distal…
The precise segmentation of intracranial aneurysms and their parent vessels (IA-Vessel) is a critical step for hemodynamic analyses, which mainly depends on computational fluid dynamics (CFD). However, current segmentation methods…
Blood vessels of the brain provide the human brain with the required nutrients and oxygen. As a vulnerable part of the cerebral blood supply, pathology of small vessels can cause serious problems such as Cerebral Small Vessel Diseases…
Cerebral aneurysms and microaneurysms are abnormal vascular dilatations with high risk of rupture. An aneurysmal rupture could cause permanent disability and even death. Finding and treating aneurysms before their rupture is very difficult…
Cerebrovascular diseases (CVD) can lead to stroke and dementia. Stroke is the second leading cause of death world wide and dementia incidence is increasing by the year. There are several markers of CVD that are visible on brain imaging,…
Magnetic continuum robots (MCRs) enable minimally invasive navigation through tortuous anatomical channels, yet axially magnetized designs have largely been limited to bending-only motion. To expand deformation capabilities, this paper…
Endovascular sealing is a new technique for the repair of abdominal aortic aneurysms. Commercially available in Europe since~2013, it takes a revolutionary approach to aneurysm repair through minimally invasive techniques. Although aneurysm…
Magnetic nanoparticles (MNPs) are the foundation of several new strategies for neural repair and neurological therapies. The fact that a remote force can act on MNPs at the cytoplasmic space constitutes the essence of many new…
Biomedical applications such as targeted drug delivery, microsurgery, and sensing rely on reaching precise areas within the body in a minimally invasive way. Artificial bacterial flagella (ABFs) have emerged as potential tools for this task…
Effects of mechanical stress on the permeability of vascular endothelium are important to normal physiology and may be critical in the development of atherosclerosis, where they can account for the patchy arterial distribution of the…
Flow diversion has become a key treatment modality for selected intracranial aneurysms, relying on the principle that a dense mesh of stent wires disrupts blood flow into the aneurysm sac, promoting thrombosis and vessel reconstruction.…