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Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, assay cost, and workflow constraints.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Jinxi Xiang , Mingjie Li , Siyu Hou , Yijiang Chen , Xiangde Luo , Yuanfeng Ji , Xiang Zhou , Ehsan Adeli , Akshay Chaudhari , Curtis P. Langlotz , Kilian M. Pohl , Ruijiang Li

Medical image data is less accessible than in other domains due to privacy and regulatory constraints. In addition, labeling requires costly, time-intensive manual image annotation by clinical experts. To overcome these challenges,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-11 Fangyijie Wang , Kevin Whelan , Félix Balado , Kathleen M. Curran , Guénolé Silvestre

The segmentation of mass lesions in digital breast tomosynthesis (DBT) images is very significant for the early screening of breast cancer. However, the high-density breast tissue often leads to high concealment of the mass lesions, which…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Haoxuan Zhang , Wenju Cui , Yuzhu Cao , Tao Tan , Jie Liu , Yunsong Peng , Jian Zheng

Augmentation for dense prediction typically relies on either sample mixing or generative synthesis. Mixing improves robustness but misaligned masks yield soft label ambiguity. Diffusion synthesis increases apparent diversity but, when…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Pengyu Jie , Wanquan Liu , Rui He , Yihui Wen , Deyu Meng , Chenqiang Gao

Generative diffusion models show promise for data augmentation. However, applying them to fine-grained tasks presents a significant challenge: ensuring synthetic images accurately capture the subtle, category-defining features critical for…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Zhiguang Lu , Qianqian Xu , Peisong Wen , Siran Dai , Qingming Huang

Fully-supervised lesion recognition methods in medical imaging face challenges due to the reliance on large annotated datasets, which are expensive and difficult to collect. To address this, synthetic lesion generation has become a…

Image and Video Processing · Electrical Eng. & Systems 2026-02-16 Wenhui Lei , Henrui Tian , Linrui Dai , Hanyu Chen , Xiaofan Zhang

Deep neural networks (DNNs) have exhibited remarkable success in the field of histopathology image analysis. On the other hand, the contemporary trend of employing large models and extensive datasets has underscored the significance of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Cong Cong , Shiyu Xuan , Sidong Liu , Maurice Pagnucco , Shiliang Zhang , Yang Song

Despite remarkable progress having been made on the problem of 3D human pose and shape estimation (HPS), current state-of-the-art methods rely heavily on either confined indoor mocap datasets or datasets generated by a rendering engine…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Yongtao Ge , Wenjia Wang , Yongfan Chen , Fanzhou Wang , Lei Yang , Hao Chen , Chunhua Shen

Segmenting tumors in histological images is vital for cancer diagnosis. While fully supervised models excel with pixel-level annotations, creating such annotations is labor-intensive and costly. Accurate histopathology image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Yinsheng He , Xingyu Li , Roger J. Zemp

As a pragmatic data augmentation tool, data synthesis has generally returned dividends in performance for deep learning based medical image analysis. However, generating corresponding segmentation masks for synthetic medical images is…

Image and Video Processing · Electrical Eng. & Systems 2023-03-23 Xiaodan Xing , Giorgos Papanastasiou , Simon Walsh , Guang Yang

Histopathology serves as the gold standard in cancer diagnosis, with clinical reports being vital in interpreting and understanding this process, guiding cancer treatment and patient care. The automation of histopathology report generation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-19 Zhengrui Guo , Jiabo Ma , Yingxue Xu , Yihui Wang , Liansheng Wang , Hao Chen

Acquiring and annotating surgical data is often resource-intensive, ethical constraining, and requiring significant expert involvement. While generative AI models like text-to-image can alleviate data scarcity, incorporating spatial…

Computer Vision and Pattern Recognition · Computer Science 2025-01-16 Aditya Bhat , Rupak Bose , Chinedu Innocent Nwoye , Nicolas Padoy

Artificial intelligence and machine learning techniques have the promise to revolutionize the field of digital pathology. However, these models demand considerable amounts of data, while the availability of unbiased training data is…

Image and Video Processing · Electrical Eng. & Systems 2023-02-14 Nati Daniel , Eliel Aknin , Ariel Larey , Yoni Peretz , Guy Sela , Yael Fisher , Yonatan Savir

Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Sarah Cechnicka , James Ball , Hadrien Reynaud , Callum Arthurs , Candice Roufosse , Bernhard Kainz

While hundreds of artificial intelligence (AI) algorithms are now approved or cleared by the US Food and Drugs Administration (FDA), many studies have shown inconsistent generalization or latent bias, particularly for underrepresented…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Luke W. Sagers , James A. Diao , Luke Melas-Kyriazi , Matthew Groh , Pranav Rajpurkar , Adewole S. Adamson , Veronica Rotemberg , Roxana Daneshjou , Arjun K. Manrai

Diffusion Generative Models (DGM) have rapidly surfaced as emerging topics in the field of computer vision, garnering significant interest across a wide array of deep learning applications. Despite their high computational demand, these…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Denisha Thakkar , Vincent Quoc-Huy Trinh , Sonal Varma , Samira Ebrahimi Kahou , Hassan Rivaz , Mahdi S. Hosseini

Automation in medical imaging is quite challenging due to the unavailability of annotated datasets and the scarcity of domain experts. In recent years, deep learning techniques have solved some complex medical imaging tasks like disease…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Soumyajyoti Dey , Sukanta Chakraborty , Utso Guha Roy , Nibaran Das

Hematoxylin and Eosin stained histopathology image analysis is essential for the diagnosis and study of complicated diseases such as cancer. Existing state-of-the-art approaches demand extensive amount of supervised training data from…

Computer Vision and Pattern Recognition · Computer Science 2017-12-15 Le Hou , Ayush Agarwal , Dimitris Samaras , Tahsin M. Kurc , Rajarsi R. Gupta , Joel H. Saltz

Histological staining is a vital step used to diagnose various diseases and has been used for more than a century to provide contrast to tissue sections, rendering the tissue constituents visible for microscopic analysis by medical experts.…

Image and Video Processing · Electrical Eng. & Systems 2020-05-08 Yijie Zhang , Kevin de Haan , Yair Rivenson , Jingxi Li , Apostolos Delis , Aydogan Ozcan

Deep learning algorithms require extensive data to achieve robust performance. However, data availability is often restricted in the medical domain due to patient privacy concerns. Synthetic data presents a possible solution to these…

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