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Model Predictive Control (MPC) is attracting tremendous attention in the autonomous driving task as a powerful control technique. The success of an MPC controller strongly depends on an accurate internal dynamics model. However, the static…

Machine Learning · Computer Science 2023-04-28 Yuan Zhang , Joschka Boedecker , Chuxuan Li , Guyue Zhou

The biophysical interactions between the T cell receptor (TCR) and its ligands determine the specificity of the cellular immune response. However, the immense diversity of receptors and ligands has made it challenging to discover…

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. Several approaches have been recently considered to encode attributes in the latent space to enhance its…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Maxime Di Folco , Cosmin I. Bercea , Emily Chan , Julia A. Schnabel

The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ…

Populations and Evolution · Quantitative Biology 2015-04-28 Yuval Elhanati , Anand Murugan , Curtis G. Callan , Thierry Mora , Aleksandra M. Walczak

Contact-rich manipulation plays an important role in daily human activities. However, uncertain physical parameters often pose significant challenges for both planning and control. A promising strategy is to develop policies that are robust…

Robotics · Computer Science 2025-05-29 Teng Xue , Amirreza Razmjoo , Suhan Shetty , Sylvain Calinon

We experimentally demonstrate that information replication by templated ligation of DNA strands inherits a kinetic proofreading mechanism and achieves significant error suppression through cascade replication. A simple simulation model…

Biological Physics · Physics 2025-12-10 Hiroyuki Aoyanagi , Yasuhiro Magi , Shoichi Toyabe

The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases. We present a random energy…

Biomolecules · Quantitative Biology 2009-11-10 Jeong-Man Park , Michael W. Deem

This paper targets the efficient construction of a safety shield for decision making in scenarios that incorporate uncertainty. Markov decision processes (MDPs) are prominent models to capture such planning problems. Reinforcement learning…

Artificial Intelligence · Computer Science 2019-11-26 Nils Jansen , Bettina Könighofer , Sebastian Junges , Alexandru C. Serban , Roderick Bloem

Despite significant progress in alignment, large language models (LLMs) remain vulnerable to adversarial attacks that elicit harmful behaviors. Activation steering techniques offer a promising inference-time intervention approach, but…

Machine Learning · Computer Science 2026-01-28 Quy-Anh Dang , Chris Ngo

Reinforcement Learning (RL) is a powerful method for controlling dynamic systems, but its learning mechanism can lead to unpredictable actions that undermine the safety of critical systems. Here, we propose RL with Adaptive Regularization…

Machine Learning · Computer Science 2024-11-01 Haozhe Tian , Homayoun Hamedmoghadam , Robert Shorten , Pietro Ferraro

Magnetic Resonance Imaging (MRI) is instrumental in clinical diagnosis, offering diverse contrasts that provide comprehensive diagnostic information. However, acquiring multiple MRI contrasts is often constrained by high costs, long…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Sanuwani Dayarathna , Kh Tohidul Islam , Bohan Zhuang , Guang Yang , Jianfei Cai , Meng Law , Zhaolin Chen

Large Language Models (LLMs) have demonstrated exceptional abilities across a broad range of language-related tasks, including generating solutions to complex reasoning problems. An effective technique to enhance LLM performance is…

Computation and Language · Computer Science 2024-12-25 Shuzhang Cai , Twumasi Mensah-Boateng , Xander Kuksov , Jing Yuan , Shaojie Tang

Performance of the existing physical layer authentication schemes could be severely affected by the imperfect estimates and variations of the communication link attributes used. The commonly adopted static hypothesis testing for physical…

Cryptography and Security · Computer Science 2018-08-08 He Fang , Xianbin Wang , Lajos Hanzo

The phenomenon of immunological memory has been known for a long time. But, the underlying mechanism is poorly understood. According to the theory of clonal selection the response to a specific invading antigen (e.g., bacteria) is offered…

Statistical Mechanics · Physics 2007-05-23 Debashish Chowdhury

A constrained Markov decision process (CMDP) approach is developed for response-adaptive procedures in clinical trials with binary outcomes. The resulting CMDP class of Bayesian response -- adaptive procedures can be used to target a…

Methodology · Statistics 2024-01-31 Stef Baas , Aleida Braaksma , Richard J. Boucherie

This work introduces a formulation of model predictive control (MPC) which adaptively reasons about the complexity of the model based on the task while maintaining feasibility and stability guarantees. Existing MPC implementations often…

Robotics · Computer Science 2024-11-07 Joseph Norby , Ardalan Tajbakhsh , Yanhao Yang , Aaron M. Johnson

Sampling-based model predictive control (MPC) has found significant success in optimal control problems with non-smooth system dynamics and cost function. Many machine learning-based works proposed to improve MPC by a) learning or…

Machine Learning · Computer Science 2024-01-08 Sungwook Yang , Chaoying Pei , Ran Dai , Chuangchuang Sun

We introduce MotionRL, the first approach to utilize Multi-Reward Reinforcement Learning (RL) for optimizing text-to-motion generation tasks and aligning them with human preferences. Previous works focused on improving numerical performance…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Xiaoyang Liu , Yunyao Mao , Wengang Zhou , Houqiang Li

Multi-task representation learning (MTRL) is an approach that learns shared latent representations across related tasks, facilitating collaborative learning that improves the overall learning efficiency. This paper studies MTRL for…

Machine Learning · Computer Science 2026-04-07 Yaoze Guo , Shana Moothedath

Reinforcement learning (RL) with rule-based reward functions has recently shown great promise in enhancing the reasoning depth and generalization ability of vision-language models (VLMs), while maintaining computational efficiency. In spite…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Yizhou Liu , Dingkang Yang , Zizhi Chen , Minghao Han , Xukun Zhang , Keliang Liu , Jingwei Wei , Lihua Zhang
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