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Replicability is a fundamental quality of scientific discoveries: we are interested in those signals that are detectable in different laboratories, study populations, across time etc. Unlike meta-analysis which accounts for experimental…

Methodology · Statistics 2021-11-19 Jingshu Wang , Lin Gui , Weijie J. Su , Chiara Sabatti , Art B. Owen

Formal verification via theorem proving enables the expressive specification and rigorous proof of software correctness, but it is difficult to scale due to the significant manual effort and expertise required. While Large Language Models…

Software Engineering · Computer Science 2025-10-30 Minghai Lu , Zhe Zhou , Danning Xie , Songlin Jia , Benjamin Delaware , Tianyi Zhang

Medical automatic diagnosis aims to imitate human doctors in real-world diagnostic processes and to achieve accurate diagnoses by interacting with the patients. The task is formulated as a sequential decision-making problem with a series of…

Machine Learning · Computer Science 2022-06-07 Hongyi Yuan , Sheng Yu

Preference-based Reinforcement Learning (PbRL) is a paradigm in which an RL agent learns to optimize a task using pair-wise preference-based feedback over trajectories, rather than explicit reward signals. While PbRL has demonstrated…

Machine Learning · Computer Science 2024-04-18 Wenhao Zhan , Masatoshi Uehara , Wen Sun , Jason D. Lee

Current proposed solutions for the high dimensionality of the MRF reconstruction problem rely on a linear compression step to reduce the matching computations and boost the efficiency of fast but non-scalable searching schemes such as the…

Quantitative Methods · Quantitative Biology 2018-09-10 Mohammad Golbabaee , Zhouye Chen , Yves Wiaux , Mike E. Davies

The T cell arm of the adaptive immune system provides the host protection against unknown pathogens by discriminating between host and foreign material. This discriminatory capability is achieved by the creation of a repertoire of cells…

Biological Physics · Physics 2022-01-03 Kevin Ng Chau , Jason T. George , José N. Onuchic , Xingcheng Lin , Herbert Levine

Reinforcement learning (RL) has been widely applied to sequential decision making, where interpretability and performance are both critical for practical adoption. Current approaches typically focus on performance and rely on post hoc…

Machine Learning · Computer Science 2025-10-07 Qianxin Yi , Shao-Bo Lin , Jun Fan , Yao Wang

Deep learning models for Electrocardiogram (ECG) diagnosis have achieved remarkable accuracy but exhibit fragility against adversarial perturbations, particularly Smooth Adversarial Perturbations (SAP) that mimic biological morphology.…

Machine Learning · Computer Science 2026-01-01 Shunbo Jia , Caizhi Liao

Recent work has demonstrated the potential of contrastive steering for jailbreaking Large Language Models (LLMs). However, existing methods rely on limited and inherently biased contrastive prompts and require laborious manual tuning of…

Cryptography and Security · Computer Science 2026-05-21 Junxi Chen , Junhao Dong , Xiaohua Xie

T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is…

Quantitative Methods · Quantitative Biology 2023-03-07 Ziqi Chen , Martin Renqiang Min , Hongyu Guo , Chao Cheng , Trevor Clancy , Xia Ning

Emerging research in Pluralistic Artificial Intelligence (AI) alignment seeks to address how intelligent systems can be designed and deployed in accordance with diverse human needs and values. We contribute to this pursuit with a dynamic…

Machine Learning · Computer Science 2024-11-01 Hadassah Harland , Richard Dazeley , Peter Vamplew , Hashini Senaratne , Bahareh Nakisa , Francisco Cruz

The mammalian adaptive immune system has evolved over millions of years to become an incredibly effective defense against foreign antigens. The adaptive immune system's humoral response creates plasma B cells and memory B cells, each with…

Cell Behavior · Quantitative Biology 2021-06-21 Stephen Lindsly , Maya Gupta , Cooper Stansbury , Indika Rajapakse

The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled…

Quantitative Methods · Quantitative Biology 2019-07-26 Alex J. Brown , Igor Snapkov , Rahmad Akbar , Milena Pavlović , Enkelejda Miho , Geir K. Sandve , Victor Greiff

This paper focuses on reinforcement learning (RL) with limited prior knowledge. In the domain of swarm robotics for instance, the expert can hardly design a reward function or demonstrate the target behavior, forbidding the use of both…

Machine Learning · Computer Science 2012-08-07 Riad Akrour , Marc Schoenauer , Michèle Sebag

This paper introduces Fast Linearized Adaptive Policy (FLAP), a new meta-reinforcement learning (meta-RL) method that is able to extrapolate well to out-of-distribution tasks without the need to reuse data from training, and adapt almost…

Machine Learning · Computer Science 2021-01-14 Matt Peng , Banghua Zhu , Jiantao Jiao

Multi-fidelity Reinforcement Learning (RL) frameworks efficiently utilize computational resources by integrating analysis models of varying accuracy and costs. The prevailing methodologies, characterized by transfer learning, human-inspired…

Machine Learning · Computer Science 2025-03-25 Akash Agrawal , Christopher McComb

Immune cells learn about their antigenic targets using tactile sense: during recognition, a highly organized yet dynamic motif, named immunological synapse, forms between immune cells and antigen-presenting cells (APCs). Via synapses,…

Biological Physics · Physics 2018-12-12 Miloš Knežević , Shenshen Wang

Leveraging multimodal data, particularly the integration of whole-slide histology images (WSIs) and transcriptomic profiles, holds great promise for improving cancer survival prediction. However, excessive redundancy in multimodal data can…

Image and Video Processing · Electrical Eng. & Systems 2025-03-07 Hong Liu , Haosen Yang , Federica Eduati , Josien P. W. Pluim , Mitko Veta

Large language models (LLMs) excel at language understanding and generation, but their enormous computational and memory requirements hinder deployment. Compression offers a potential solution to mitigate these constraints. However, most…

Machine Learning · Computer Science 2026-05-19 Huanrong Liu , Chunlin Tian , Xuyang Wei , Qingbiao Li , Li Li

In order for robots to perform mission-critical tasks, it is essential that they are able to quickly adapt to changes in their environment as well as to injuries and or other bodily changes. Deep reinforcement learning has been shown to be…

Robotics · Computer Science 2017-10-19 Ayaka Kume , Eiichi Matsumoto , Kuniyuki Takahashi , Wilson Ko , Jethro Tan