Related papers: Non-invasive Reversible Software-based Electron FL…
We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiology experiments. UHDR electron beams were controlled by a…
Irradiations at Ultra High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radio-therapy with reduced harm to normal tissues. This…
Purpose: In this study, procedures were developed to achieve efficient reversible conversion of a clinical linear accelerator (LINAC) and deliver electron FLASH (eFLASH) or conventional beams to the treatment room isocenter. Material &…
Background: Use of a linear accelerator in ultra-high dose rate (UHDR) mode can provide a conduit for wider access to UHDR FLASH effects, sparing normal tissue, but care needs to be taken in the use of such systems to ensure errors are…
Ultra-high dose rate electron sources require dose rate independent dosimeters and a calibrated dose control system for accurate delivery. In this study, we developed a single-pulse dose monitoring and a real-time dose-based control system…
Background & Purpose: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials.…
Objective: While FLASH radiotherapy is recognized for short-term normal tissue sparing, its durability in late-responding organs remains uncertain, limiting clinical adoption. With its clinical importance and steep dose-response, the spinal…
The Linear Accelerator 4 (LINAC 4) is designed to accelerate negative hydrogen ions to high energies for injection into the Large Hadron Collider (LHC), where it has been supplying proton beams since 2020. LINAC 4 accelerates negative…
Background: The normal tissue sparing effect of ultra-high dose rate irradiation (>40 Gy/s, UHDR), as compared to conventional dose rate (CONV), has attracted significant research interest for FLASH radiotherapy (RT). Accurate, dose rate…
Background: Clinical linear accelerators are an accessible platform for preclinical research on the biological effects of ultra rapid electron irradiation (FLASH). However, they are not inherently designed for the accurate pulse control…
Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment…
The use of existing linacs, and in particular light source injectors, for free-electron laser (FEL) experiments is becoming more common due to the desire to test FELs at ever shorter wavelengths. The high-brightness, high-current beams…
Background: FLASH radiotherapy is a treatment regime that delivers therapeutic dose to tumors at an ultra-high dose rate while maintaining adequate normal tissue sparing. However, a comprehensive understanding of the underlying mechanisms,…
We present a detailed study of the six-dimensional phase space of the electron beam produced by the Cornell Energy Recovery Linac Photoinjector, a high-brightness, high repetition rate (1.3 GHz) DC photoemission source designed to drive a…
The increasing interest in FLASH-RT has lead to the conversion of linear accelerators to enable ultra-high dose rate (UHDR) beams for preclinical research. Dosimetry hereof remains challenging with several crucial aspects missing. This work…
The conception of High Power Linac developed in Russian accelerator centres is based on the use of independently phased SC resonators with quadrupole lenses between them. The type and parameters of the resonators as well as focusing…
A dedicated clinical synchrotron facility for cancer therapy using energetic proton and ion beams (C, He and O) has been designed at GSI for the Radiologische Universitaetsklinik at Heidelberg, Germany. The design of the injector linac is…
A room temperature heavy ion linac has been proposed as a new injector of CSRm (the main Cooler Storage Ring) at HIRFL (Heavy Ion Research Facility in Lanzhou), which is expected to improve the performance of HIRFL. The linac injector can…
Purpose: Commercial UHDR platforms deliver Ultra-High Dose Rate (UHDR) doses at discrete combinations of pulse parameters including pulse width (PW), pulse repetition frequency (PRF) and number of pulses (N), which dictate unique…
The second phase accelerator for the Dual Axis Hydrodynamic Test facility (DARHT) is designed to provide an electron beam pulse that is 2 microsec long, 2kA, and 20 MeV in particle energy. The injector provides 3.2 MeV so that the linac…