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High-throughput electron microscopy allows recording of lar- ge stacks of neural tissue with sufficient resolution to extract the wiring diagram of the underlying neural network. Current efforts to automate this process focus mainly on the…

Computer Vision and Pattern Recognition · Computer Science 2018-07-17 Julia Buhmann , Renate Krause , Rodrigo Ceballos Lentini , Nils Eckstein , Matthew Cook , Srinivas Turaga , Jan Funke

The development of learning-based methods has greatly improved the detection of synapses from electron microscopy (EM) images. However, training a model for each dataset is time-consuming and requires extensive annotations. Additionally, it…

Computer Vision and Pattern Recognition · Computer Science 2023-09-01 Qi Chen , Wei Huang , Yueyi Zhang , Zhiwei Xiong

An open challenge problem at the forefront of modern neuroscience is to obtain a comprehensive mapping of the neural pathways that underlie human brain function; an enhanced understanding of the wiring diagram of the brain promises to lead…

Reconstructing neuronal circuits at the level of synapses is a central problem in neuroscience and becoming a focus of the emerging field of connectomics. To date, electron microscopy (EM) is the most proven technique for identifying and…

Quantitative Methods · Quantitative Biology 2014-12-05 Stephen M. Plaza , Toufiq Parag , Gary B. Huang , Donald J. Olbris , Mathew A. Saunders , Patricia K. Rivlin

In this work, we propose a learning framework for identifying synapses using a deep and wide multi-scale recursive (DAWMR) network, previously considered in image segmentation applications. We apply this approach on electron microscopy data…

Computer Vision and Pattern Recognition · Computer Science 2014-09-08 Gary B. Huang , Stephen Plaza

Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2017-02-27 Shibani Santurkar , David Budden , Alexander Matveev , Heather Berlin , Hayk Saribekyan , Yaron Meirovitch , Nir Shavit

Separating synapses into different classes based on their appearance in EM images has many applications in biology. Examples may include assigning a neurotransmitter to a particular class, or separating synapses whose strength can be…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Aarav Shetty , Gary B Huang

Extracting a connectome from an electron microscopy (EM) data set requires identification of neurons and determination of synapses between neurons. As manual extraction of this information is very time-consuming, there has been extensive…

Computer Vision and Pattern Recognition · Computer Science 2016-04-12 Gary B. Huang , Louis K. Scheffer , Stephen M. Plaza

Neural circuit reconstruction at single synapse resolution is increasingly recognized as crucially important to decipher the function of biological nervous systems. Volume electron microscopy in serial transmission or scanning mode has been…

Computer Vision and Pattern Recognition · Computer Science 2018-05-09 Larissa Heinrich , Jan Funke , Constantin Pape , Juan Nunez-Iglesias , Stephan Saalfeld

Instance segmentation in electron microscopy (EM) volumes is tough due to complex shapes and sparse annotations. Self-supervised learning helps but still struggles with intricate visual patterns in EM. To address this, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Yinda Chen , Wei Huang , Xiaoyu Liu , Shiyu Deng , Qi Chen , Zhiwei Xiong

The promise of extracting connectomes and performing useful analysis on large electron microscopy (EM) datasets has been an elusive dream for many years. Tracing in even the smallest portions of neuropil requires copious human annotation,…

Computer-aided analysis of biological microscopy data has seen a massive improvement with the utilization of general-purpose deep learning techniques. Yet, in microscopy studies of multi-organism systems, the problem of collision and…

Computer Vision and Pattern Recognition · Computer Science 2023-10-09 Albert Alonso , Julius B. Kirkegaard

Synaptic connectivity detection is a critical task for neural reconstruction from Electron Microscopy (EM) data. Most of the existing algorithms for synapse detection do not identify the cleft location and direction of connectivity…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Toufiq Parag , Daniel Berger , Lee Kamentsky , Benedikt Staffler , Donglai Wei , Moritz Helmstaedter , Jeff W. Lichtman , Hanspeter Pfister

In multimedia understanding tasks, corrupted samples pose a critical challenge, because when fed to machine learning models they lead to performance degradation. In the past, three groups of approaches have been proposed to handle noisy…

Computer Vision and Pattern Recognition · Computer Science 2024-03-01 Francesco Barbato , Umberto Michieli , Mehmet Kerim Yucel , Pietro Zanuttigh , Mete Ozay

Segmentation is a crucial step in microscopy image analysis. Numerous approaches have been developed over the past years, ranging from classical segmentation algorithms to advanced deep learning models. While U-Net remains one of the most…

Image and Video Processing · Electrical Eng. & Systems 2024-09-26 Illia Tsiporenko , Pavel Chizhov , Dmytro Fishman

Tissue semantic segmentation is one of the key tasks in computational pathology. To avoid the expensive and laborious acquisition of pixel-level annotations, a wide range of studies attempt to adopt the class activation map (CAM), a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Zijie Fang , Yifeng Wang , Peizhang Xie , Zhi Wang , Yongbing Zhang

We present three multi-scale similarity learning architectures, or DeepSim networks. These models learn pixel-level matching with a contrastive loss and are agnostic to the geometry of the considered scene. We establish a middle ground…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Mohamed Ali Chebbi , Ewelina Rupnik , Marc Pierrot-Deseilligny , Paul Lopes

Oceanic processes at fine scales are crucial yet difficult to observe accurately due to limitations in satellite and in-situ measurements. The Surface Water and Ocean Topography (SWOT) mission provides high-resolution Sea Surface Height…

Atmospheric and Oceanic Physics · Physics 2025-03-28 Eugenio Cutolo , Carlos Granero-Belinchon , Ptashanna Thiraux , Jinbo Wang , Ronan Fablet

Deep neural networks (DNNs) have become the driving force behind recent artificial intelligence (AI) research. An important problem with implementing a neural network is the design of its architecture. Typically, such an architecture is…

Neural and Evolutionary Computing · Computer Science 2021-03-30 Shayan Hassantabar , Zeyu Wang , Niraj K. Jha

Deep Neural Networks (DNN) have achieved human level performance in many image analytics tasks but DNNs are mostly deployed to GPU platforms that consume a considerable amount of power. Brain-inspired spiking neuromorphic chips consume low…

Neural and Evolutionary Computing · Computer Science 2016-05-26 Antonio Jimeno Yepes , Jianbin Tang
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