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Sharing health and behavioral data raises significant privacy concerns, as conventional de-identification methods are susceptible to privacy attacks. Differential Privacy (DP) provides formal guarantees against re-identification risks, but…

The use of synthetic data in health applications raises privacy concerns, yet the lack of open frameworks for privacy evaluations has slowed its adoption. A major challenge is the absence of accessible benchmark datasets for evaluating…

Machine Learning · Computer Science 2026-01-21 Bing Hu , Yixin Li , Asma Bahamyirou , Helen Chen

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu

Social platforms such as Reddit have a network of communities of shared interests, with a prevalence of posts and comments from which one can infer users' Personal Information Identifiers (PIIs). While such self-disclosures can lead to…

Computation and Language · Computer Science 2025-08-01 Shalini Jangra , Suparna De , Nishanth Sastry , Saeed Fadaei

Historical data from previous clinical trials, observational studies and health records may be utilized in analysis of clinical trials data to strengthen inference. Under the Bayesian framework incorporation of information obtained from any…

Applications · Statistics 2021-03-23 Shirin Golchi

We propose AIM, a new algorithm for differentially private synthetic data generation. AIM is a workload-adaptive algorithm within the paradigm of algorithms that first selects a set of queries, then privately measures those queries, and…

Databases · Computer Science 2024-06-14 Ryan McKenna , Brett Mullins , Daniel Sheldon , Gerome Miklau

Deep generative models and synthetic medical data have shown significant promise in addressing key challenges in healthcare, such as privacy concerns, data bias, and the scarcity of realistic datasets. While research in this area has grown…

Machine Learning · Computer Science 2025-02-05 Krishan Agyakari Raja Babu , Supriti Mulay , Om Prabhu , Mohanasankar Sivaprakasam

Individual-level data (microdata) that characterizes a population, is essential for studying many real-world problems. However, acquiring such data is not straightforward due to cost and privacy constraints, and access is often limited to…

Machine Learning · Computer Science 2022-12-13 Angeela Acharya , Siddhartha Sikdar , Sanmay Das , Huzefa Rangwala

Generation of realistic synthetic data has garnered considerable attention in recent years, particularly in the health research domain due to its utility in, for instance, sharing data while protecting patient privacy or determining optimal…

Other Statistics · Statistics 2025-01-30 Niki Z. Petrakos , Erica E. M. Moodie , Nicolas Savy

Privacy Preserving Synthetic Data Generation (PP-SDG) has emerged to produce synthetic datasets from personal data while maintaining privacy and utility. Differential privacy (DP) is the property of a PP-SDG mechanism that establishes how…

Cryptography and Security · Computer Science 2025-07-23 Frederik Marinus Trudslev , Matteo Lissandrini , Juan Manuel Rodriguez , Martin Bøgsted , Daniele Dell'Aglio

Synthetic data from generative models emerges as the privacy-preserving data sharing solution. Such a synthetic data set shall resemble the original data without revealing identifiable private information. Till date, the prior focus on…

Machine Learning · Computer Science 2025-07-23 Chaoyi Zhu , Jiayi Tang , Juan F. Pérez , Marten van Dijk , Lydia Y. Chen

The generation of high-quality synthetic data presents significant challenges in machine learning research, particularly regarding statistical fidelity and uncertainty quantification. Existing generative models produce compelling synthetic…

Machine Learning · Computer Science 2025-05-13 Rahul Vishwakarma , Shrey Dharmendra Modi , Vishwanath Seshagiri

Sharing medical data for machine learning model training purposes is often impossible due to the risk of disclosing identifying information about individual patients. Synthetic data produced by generative artificial intelligence (genAI)…

Machine Learning · Computer Science 2026-02-12 Rustam Zhumagambetov , Niklas Giesa , Sebastian D. Boie , Stefan Haufe

The digitization of medical records ushered in a new era of big data to clinical science, and with it the possibility that data could be shared, to multiply insights beyond what investigators could abstract from paper records. The need to…

Machine Learning · Computer Science 2021-06-03 Ofer Mendelevitch , Michael D. Lesh

Accurate models of patient survival probabilities provide important information to clinicians prescribing care for life-threatening and terminal ailments. A recently developed class of models - known as individual survival distributions…

Machine Learning · Computer Science 2019-06-27 Samuel Sokota , Ryan D'Orazio , Khurram Javed , Humza Haider , Russell Greiner

In the medical domain, acquiring large datasets is challenging due to both accessibility issues and stringent privacy regulations. Consequently, data availability and privacy protection are major obstacles to applying machine learning in…

Image and Video Processing · Electrical Eng. & Systems 2025-07-02 Wenwu Tang , Khaled Seyam , Bin Yang

Supervised training of an automated medical image analysis system often requires a large amount of expert annotations that are hard to collect. Moreover, the proportions of data available across different classes may be highly imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2019-12-10 Yuan Xue , Jiarong Ye , Rodney Long , Sameer Antani , Zhiyun Xue , Xiaolei Huang

Multimodal self-supervised representation learning has consistently proven to be a highly effective method in medical image analysis, offering strong task performance and producing biologically informed insights. However, these methods…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Lucas Farndale , Chris Walsh , Robert Insall , Ke Yuan

Synthetic data generation has become a key ingredient for training machine learning procedures, addressing tasks such as data augmentation, analysing privacy-sensitive data, or visualising representative samples. Assessing the quality of…

Machine Learning · Statistics 2022-06-02 Wenkai Xu , Gesine Reinert

Synthetic cardiac MRI (CMRI) generation has emerged as a promising strategy to overcome the scarcity of annotated medical imaging data. Recent advances in GANs, VAEs, diffusion probabilistic models, and flow-matching techniques aim to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Ishan Kumarasinghe , Dasuni Kawya , Madhura Edirisooriya , Isuri Devindi , Isuru Nawinne , Vajira Thambawita