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Individual patient data (IPD) from oncology trials are essential for reliable evidence synthesis but are rarely publicly available, necessitating reconstruction from published Kaplan-Meier (KM) curves. Existing reconstruction methods suffer…

Methodology · Statistics 2026-01-23 Lang Lang , Yao Zhao , Qiuxin Gao , Yanxun Xu

Access to real-world healthcare data is limited by stringent privacy regulations and data imbalances, hindering advancements in research and clinical applications. Synthetic data presents a promising solution, yet existing methods often…

Machine Learning · Computer Science 2025-03-11 Nicholas I-Hsien Kuo , Blanca Gallego , Louisa Jorm

Background: Synthetic data has been proposed as a solution for sharing anonymized versions of sensitive biomedical datasets. Ideally, synthetic data should preserve the structure and statistical properties of the original data, while…

Machine Learning · Computer Science 2024-10-24 Ileana Montoya Perez , Parisa Movahedi , Valtteri Nieminen , Antti Airola , Tapio Pahikkala

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

The biomedical field is among the sectors most impacted by the increasing regulation of Artificial Intelligence (AI) and data protection legislation, given the sensitivity of patient information. However, the rise of synthetic data…

Machine Learning · Computer Science 2024-04-26 Eric Macias-Fassio , Aythami Morales , Cristina Pruenza , Julian Fierrez

The state-of-the-art dimensionality reduction approaches largely rely on complicated optimization procedures. On the other hand, closed-form approaches requiring merely eigen-decomposition do not have enough sophistication and nonlinearity.…

Machine Learning · Computer Science 2023-08-14 Chengrui Li , Anqi Wu

Healthcare research and development face significant obstacles due to data scarcity and stringent privacy regulations, such as HIPAA and the GDPR, restricting access to essential real-world medical data. These limitations impede innovation,…

Machine Learning · Computer Science 2025-10-17 Md Ibrahim Shikder Mahin , Md Shamsul Arefin , Md Tanvir Hasan

Kaplan-Meier estimators are essential tools in survival analysis, capturing the survival behavior of a cohort. Their accuracy improves with large, diverse datasets, encouraging data holders to collaborate for more precise estimations.…

Cryptography and Security · Computer Science 2024-07-30 Shadi Rahimian , Raouf Kerkouche , Ina Kurth , Mario Fritz

Access to large-scale high-quality healthcare databases is key to accelerate medical research and make insightful discoveries about diseases. However, access to such data is often limited by patient privacy concerns, data sharing…

Training generative machine learning models to produce synthetic tabular data has become a popular approach for enhancing privacy in data sharing. As this typically involves processing sensitive personal information, releasing either the…

Cryptography and Security · Computer Science 2026-02-02 Georgi Ganev , Emiliano De Cristofaro

The widespread adoption of electronic health records and digital healthcare data has created a demand for data-driven insights to enhance patient outcomes, diagnostics, and treatments. However, using real patient data presents privacy and…

Machine Learning · Computer Science 2023-11-15 Aryan Jadon , Shashank Kumar

Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine…

Automatic detection of depression is a rapidly growing field of research at the intersection of psychology and machine learning. However, with its exponential interest comes a growing concern for data privacy and scarcity due to the…

Machine Learning · Computer Science 2024-11-27 Andrea Kang , Jun Yu Chen , Zoe Lee-Youngzie , Shuhao Fu

Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

Access to electronic health records (EHRs) for digital health research is often limited by privacy regulations and institutional barriers. Synthetic EHRs have been proposed as a way to enable safe and sovereign data sharing; however,…

Machine Learning · Computer Science 2026-03-10 Guanglin Zhou , Armin Catic , Motahare Shabestari , Matthew Young , Chaiquan Li , Katrina Poppe , Sebastiano Barbieri

Currently there is strong interest in data-driven approaches to medical image classification. However, medical imaging data is scarce, expensive, and fraught with legal concerns regarding patient privacy. Typical consent forms only allow…

Computer Vision and Pattern Recognition · Computer Science 2018-01-10 John T. Guibas , Tejpal S. Virdi , Peter S. Li

We introduce the DP-auto-GAN framework for synthetic data generation, which combines the low dimensional representation of autoencoders with the flexibility of Generative Adversarial Networks (GANs). This framework can be used to take in…

Machine Learning · Computer Science 2020-12-11 Uthaipon Tantipongpipat , Chris Waites , Digvijay Boob , Amaresh Ankit Siva , Rachel Cummings

The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across…

Machine Learning · Computer Science 2023-02-01 Jin Li , Benjamin J. Cairns , Jingsong Li , Tingting Zhu

Creation of a synthetic dataset that faithfully represents the data distribution and simultaneously preserves privacy is a major research challenge. Many space partitioning based approaches have emerged in recent years for answering…

Cryptography and Security · Computer Science 2023-06-26 Eleonora Kreačić , Navid Nouri , Vamsi K. Potluru , Tucker Balch , Manuela Veloso

Background: Heart failure (HF) research is constrained by limited access to large, shareable datasets due to privacy regulations and institutional barriers. Synthetic data generation offers a promising solution to overcome these challenges…

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