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In this study, we explore a mathematical model for tissue growth focusing on the interplay between multiple cell subpopulations with distinct phenotypic characteristics. The model addresses the dynamics of tissue growth influenced by…

Analysis of PDEs · Mathematics 2024-09-05 Tomasz Dębiec , Mainak Mandal , Markus Schmidtchen

Several recent papers have addressed modelling of the tissue growth by the multi-phase models where the velocity is related to the pressure by one of the physical laws (Stoke's, Brinkman's or Darcy's). While each of these models has been…

Analysis of PDEs · Mathematics 2023-08-24 Charles Elbar , Jakub Skrzeczkowski

In this paper we study singular limits of congestion-averse growth models, connecting different models describing the effect of congestion. These models arise in particular in the context of tissue growth. The main ingredient of our…

Analysis of PDEs · Mathematics 2025-03-25 Noemi David , Matt Jacobs , Inwon Kim

In recent years, there has been a spike in the interest in multi-phase tissue growth models. Depending on the type of tissue, the velocity is linked to the pressure through Stoke's law, Brinkman's law or Darcy's law. While each of these…

Analysis of PDEs · Mathematics 2023-03-21 Noemi David , Tomasz Dębiec , Mainak Mandal , Markus Schmidtchen

In this work we study a tissue growth model with applications to tumour growth. The model is based on that of Perthame, Quir\'os, and V\'azquez proposed in 2014 but incorporates the advective effects caused, for instance, by the presence of…

Analysis of PDEs · Mathematics 2021-03-04 Noemi David , Markus Schmidtchen

We study a system describing the compressible barotropic fluids interacting with (visco) elastic solid shell/plate. In particular, the elastic structure is part of the moving boundary of the fluid, and the Navier-slip type boundary…

Analysis of PDEs · Mathematics 2026-05-20 Yadong Liu , Sourav Mitra , Šárka Nečasová

We present a two-species model with applications in tumour modelling. The main novelty is the coupling of both species through the so-called Brinkman law which is typically used in the context of visco-elastic media, where the velocity…

Analysis of PDEs · Mathematics 2019-10-22 Tomasz Dębiec , Markus Schmidtchen

We study a model introduced by Perthame and Vauchelet that describes the growth of a tumor governed by Brinkman's Law, which takes into account friction between the tumor cells. We adopt the viscosity solution approach to establish an…

Analysis of PDEs · Mathematics 2017-04-24 Inwon Kim , Olga Turanova

In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…

Analysis of PDEs · Mathematics 2018-11-19 Matthias Ebenbeck , Harald Garcke

A mathematical model for tissue growth is considered. This model describes the dynamics of the density of cells due to pressure forces and proliferation. It is known that such cell population model converges at the incompressible limit…

Analysis of PDEs · Mathematics 2017-03-01 Sophie Hecht , Nicolas Vauchelet

We consider a (degenerate) cross-diffusion model of tumor growth structured by phenotypic trait. We prove the existence of weak solutions and the incompressible limit as the pressure becomes stiff extending methods recently introduced in…

Analysis of PDEs · Mathematics 2023-04-04 Noemi David

A comprehensive Darcy-type law for viscoplastic fluids is proposed. Different regimes of yield-stress fluid flow in porous media can be categorised based on the Bingham number (i.e. the ratio of the yield stress to the characteristic…

Fluid Dynamics · Physics 2025-08-12 Emad Chaparian

We analyze the asymptotic behavior of the Boussinesq-Darcy system describing convection in layered porous media in the limit where the permeability of one layer tends to zero. We show that the limiting dynamics are governed by the…

Analysis of PDEs · Mathematics 2026-03-03 Kaijian Sha , Xiaoming Wang

We study incompressible fluid flow through a thin poroelastic layer and rigorously derive a macroscopic model when the thickness of the layer tends to zero. Within the layer we assume a periodic structure and both, the periodicity and the…

Analysis of PDEs · Mathematics 2024-03-08 Markus Gahn

Various models of tumor growth are available in the litterature. A first class describes the evolution of the cell number density when considered as a continuous visco-elastic material with growth. A second class, describes the tumor as a…

Analysis of PDEs · Mathematics 2016-02-17 Benoit Perthame , Nicolas Vauchelet

We analyze the continuous time evolution of a $d$-dimensional system of $N$ self propelled particles with a kinematic constraint on the velocities inspired by the original Vicsek's one \cite{VCB-JCS}. Interactions among particles are…

Mathematical Physics · Physics 2014-07-29 Michele Gianfelice , Enza Orlandi

In this paper we study a cross-diffusion system whose coefficient matrix is non-symmetric and degenerate. The system arises in the study of tissue growth with autophagy. The existence of a weak solution is established. We also investigate…

Analysis of PDEs · Mathematics 2021-06-22 Jian-Guo Liu , Xiangsheng Xu

We study a porous medium equation that models tissue growth in a heterogeneous environment. We show that, in the incompressible limit, solutions converge to those of a weak form of a Hele-Shaw type free boundary problem. To obtain enough…

Analysis of PDEs · Mathematics 2025-12-11 Anthony Sulak , Olga Turanova

We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…

Analysis of PDEs · Mathematics 2024-03-12 Jiajun Tong , Yuming Paul Zhang

We study the incompressible limit of the porous medium equation with a reaction term that is non-monotone with respect to the pressure variable. More specifically we consider reaction terms that are either bistable or monostable. We show…

Analysis of PDEs · Mathematics 2022-08-22 Inwon Kim , Antoine Mellet
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