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Recent advances in reasoning with large language models (LLMs)has shown remarkable reasoning capabilities in domains such as mathematics and coding, yet their application to clinical diagnosis remains underexplored. Here, we introduce…

Computation and Language · Computer Science 2025-04-16 Wuyang Lan , Wenzheng Wang , Changwei Ji , Guoxing Yang , Yongbo Zhang , Xiaohong Liu , Song Wu , Guangyu Wang

Causal reasoning is a core component of intelligence. Large language models (LLMs) have shown impressive capabilities in generating human-like text, raising questions about whether their responses reflect true understanding or statistical…

Artificial Intelligence · Computer Science 2025-06-09 Hanna M. Dettki , Brenden M. Lake , Charley M. Wu , Bob Rehder

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Numerous benchmarks aim to evaluate the capabilities of Large Language Models (LLMs) for causal inference and reasoning. However, many of them can likely be solved through the retrieval of domain knowledge, questioning whether they achieve…

Machine Learning · Computer Science 2024-07-12 Linying Yang , Vik Shirvaikar , Oscar Clivio , Fabian Falck

The causal capabilities of large language models (LLMs) are a matter of significant debate, with critical implications for the use of LLMs in societally impactful domains such as medicine, science, law, and policy. We conduct a "behavorial"…

Artificial Intelligence · Computer Science 2024-08-21 Emre Kıcıman , Robert Ness , Amit Sharma , Chenhao Tan

Causal reasoning capability is critical in advancing large language models (LLMs) toward strong artificial intelligence. While versatile LLMs appear to have demonstrated capabilities in understanding contextual causality and providing…

Artificial Intelligence · Computer Science 2025-06-30 Haoang Chi , He Li , Wenjing Yang , Feng Liu , Long Lan , Xiaoguang Ren , Tongliang Liu , Bo Han

Large language models (LLMs) are increasingly explored for clinical decision support, yet most evaluations are conducted in English, leaving their reliability in other languages uncertain. Here we evaluate the impact of prompting language…

Computation and Language · Computer Science 2026-05-20 Adrien Bazoge , Josselin Corvellec , Sofiane Djillali Sid-Ahmed , Pierre-Antoine Gourraud

Causal reasoning capabilities are essential for large language models (LLMs) in a wide range of applications, such as education and healthcare. But there is still a lack of benchmarks for a better understanding of such capabilities. Current…

Computation and Language · Computer Science 2024-12-25 Ruibo Tu , Hedvig Kjellström , Gustav Eje Henter , Cheng Zhang

Structured output from large language models (LLMs) has enhanced efficiency in processing generated information and is increasingly adopted in industrial applications. Prior studies have investigated the impact of structured output on LLMs'…

Computation and Language · Computer Science 2025-12-22 Han Yuan , Yue Zhao , Li Zhang , Wuqiong Luo , Zheng Ma

Medical reasoning in large language models (LLMs) aims to emulate clinicians' diagnostic thinking, but current benchmarks such as MedQA-USMLE, MedMCQA, and PubMedQA often mix reasoning with factual recall. We address this by separating 11…

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Numerous decision-making tasks require estimating causal effects under interventions on different parts of a system. As practitioners consider using large language models (LLMs) to automate decisions, studying their causal reasoning…

Machine Learning · Computer Science 2024-12-24 Tejas Kasetty , Divyat Mahajan , Gintare Karolina Dziugaite , Alexandre Drouin , Dhanya Sridhar

Large Language Models (LLMs) and causal learning each hold strong potential for clinical decision making (CDM). However, their synergy remains poorly understood, largely due to the lack of systematic benchmarks evaluating their integration…

Machine Learning · Computer Science 2025-11-14 Linna Wang , Zhixuan You , Qihui Zhang , Jiunan Wen , Ji Shi , Yimin Chen , Yusen Wang , Fanqi Ding , Ziliang Feng , Li Lu

This study explores the potential of natural language models, including large language models, to extract causal relations from medical texts, specifically from Clinical Practice Guidelines (CPGs). The outcomes causality extraction from…

Computation and Language · Computer Science 2024-07-16 Seethalakshmi Gopalakrishnan , Luciana Garbayo , Wlodek Zadrozny

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

In time-critical decisions, human decision-makers can interact with AI-enabled situation-aware software to evaluate many imminent and possible scenarios, retrieve billions of facts, and estimate different outcomes based on trillions of…

Artificial Intelligence · Computer Science 2024-05-07 Manjiang Yu , Xue Li

The safe deployment of large language models (LLMs) in high-stakes fields like biomedicine, requires them to be able to reason about cause and effect. We investigate this ability by testing 13 open-source LLMs on a fundamental task:…

Computation and Language · Computer Science 2026-03-13 Sydney Anuyah , Sneha Shajee-Mohan , Ankit-Singh Chauhan , Sunandan Chakraborty

This study investigates the efficacy of Large Language Models (LLMs) in causal discovery. Using newly available open-source LLMs, OLMo and BLOOM, which provide access to their pre-training corpora, we investigate how LLMs address causal…

Computation and Language · Computer Science 2025-10-13 Tao Feng , Lizhen Qu , Niket Tandon , Zhuang Li , Xiaoxi Kang , Gholamreza Haffari

This study investigates how accurately different evaluation metrics capture the quality of causal explanations in automatically generated diagnostic reports. We compare six metrics: BERTScore, Cosine Similarity, BioSentVec, GPT-White,…

Computation and Language · Computer Science 2025-06-24 Yousang Cho , Key-Sun Choi

The use of Large Language Models (LLMs) in mathematical reasoning has become a cornerstone of related research, demonstrating the intelligence of these models and enabling potential practical applications through their advanced performance,…

Computation and Language · Computer Science 2024-12-20 Kathrin Seßler , Yao Rong , Emek Gözlüklü , Enkelejda Kasneci
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