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This paper deals with the estimation of rare event probabilities using importance sampling (IS), where an optimal proposal distribution is computed with the cross-entropy (CE) method. Although, IS optimized with the CE method leads to an…

Computation · Statistics 2020-02-05 Patrick Héas

The quantitative structure-activity relationship (QSAR) regression model is a commonly used technique for predicting biological activities of compounds using their molecular descriptors. Predictions from QSAR models can help, for example,…

Biomolecules · Quantitative Biology 2023-04-04 Yuting Xu , Andy Liaw , Robert P. Sheridan , Vladimir Svetnik

Imbalanced regression occurs when continuous target variables have skewed distributions, creating sparse regions that are difficult for machine learning models to predict accurately. This issue particularly affects neural networks, which…

Machine Learning · Computer Science 2025-04-22 Shayan Alahyari , Mike Domaratzki

Multiple imputation (MI) has become one of the main procedures used to treat missing data, but the guidelines from the methodological literature are not easily transferred to multilevel research. For models including random slopes, proper…

Methodology · Statistics 2016-06-30 Simon Grund , Oliver Lüdtke , Alexander Robitzsch

In real-world applications, we can encounter situations when a well-trained model has to be used to predict from a damaged dataset. The damage caused by missing or corrupted values can be either on the level of individual instances or on…

Machine Learning · Computer Science 2019-11-12 Magda Friedjungová , Daniel Vašata , Marcel Jiřina

Training models on highly unbalanced data is admitted to be a challenging task for machine learning algorithms. Current studies on deep learning mainly focus on data sets with balanced class labels or unbalanced data, but with massive…

Machine Learning · Computer Science 2020-02-27 Louis Marceau , Lingling Qiu , Nick Vandewiele , Eric Charton

Univariate isotonic regression (IR) has been used for nonparametric estimation in dose-response and dose-finding studies. One undesirable property of IR is the prevalence of piecewise-constant stretches in its estimates, whereas the…

Methodology · Statistics 2017-01-24 Assaf P. Oron , Nancy Flournoy

For the past two decades, single-index model, a special case of projection pursuit regression, has proven to be an efficient way of coping with the high dimensional problem in nonparametric regression. In this paper, based on weakly…

Statistics Theory · Mathematics 2007-05-23 Li Wang , Lijian Yang

In this paper, we clarify the relations between the existing sets of regularity conditions for convergence rates of nonparametric indirect regression (NPIR) and nonparametric instrumental variables (NPIV) regression models. We establish…

Statistics Theory · Mathematics 2007-09-14 Xiaohong Chen , Markus Reiss

The aim of Active Learning is to select the most informative samples from an unlabelled set of data. This is useful in cases where the amount of data is large and labelling is expensive, such as in machine vision or medical imaging. Two…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Julien Combes , Alexandre Derville , Jean-François Coeurjolly

Pooling genome-wide association studies of multiple related traits can substantially increase power for detecting genetic variants with pleiotropic effects. ASSET, which exhaustively searches all subsets of studies for association signals,…

Methodology · Statistics 2026-04-28 Samuel Anyaso-Samuel , Thong Luong , Fei Qin , Jiyeon Choi , Kai Yu , Paul S. Albert , Jianxin Shi

Missing values in tabular data restrict the use and performance of machine learning, requiring the imputation of missing values. The most popular imputation algorithm is arguably multiple imputations using chains of equations (MICE), which…

Machine Learning · Computer Science 2022-03-01 Manar D Samad , Sakib Abrar , Norou Diawara

Missing data represents a fundamental challenge in machine learning applications, often reducing model performance and reliability. This problem is particularly acute in fields like bioinformatics and clinical machine learning, where…

Machine Learning · Computer Science 2025-09-04 Fatemeh Azad , Zoran Bosnić , Matjaž Kukar

Machine learning components commonly appear in larger decision-making pipelines; however, the model training process typically focuses only on a loss that measures accuracy between predicted values and ground truth values. Decision-focused…

Machine Learning · Computer Science 2019-07-19 Aaron Ferber , Bryan Wilder , Bistra Dilkina , Milind Tambe

Compressive-sensing-based uncertainty quantification methods have become a pow- erful tool for problems with limited data. In this work, we use the sliced inverse regression (SIR) method to provide an initial guess for the alternating…

Numerical Analysis · Mathematics 2018-09-11 Xiu Yang , Weixuan Li , Alexandre Tartakovsky

The challenge of \textbf{imbalanced regression} arises when standard Empirical Risk Minimization (ERM) biases models toward high-frequency regions of the data distribution, causing severe degradation on rare but high-impact ``tail'' events.…

Machine Learning · Statistics 2025-12-09 Enrico Camporeale

Comparative effectiveness research often involves evaluating the differences in the risks of an event of interest between two or more treatments using observational data. Often, the post-treatment outcome of interest is whether the event…

Methodology · Statistics 2022-05-18 Youfei Yu , Min Zhang , Bhramar Mukherjee

Individualized treatment rules (ITRs) have been widely applied in many fields such as precision medicine and personalized marketing. Beyond the extensive studies on ITR for binary or multiple treatments, there is considerable interest in…

Methodology · Statistics 2024-03-08 Qi Xu , Xiaoke Cao , Geping Chen , Hanqi Zeng , Haoda Fu , Annie Qu

Sequential importance sampling algorithms have been defined to estimate likelihoods in models of ancestral population processes. However, these algorithms are based on features of the models with constant population size, and become…

Statistics Theory · Mathematics 2016-03-24 Coralie Merle , Raphaël Leblois , François Rousset , Pierre Pudlo

In this paper, we develop a new sequential regression modeling approach for data streams. Data streams are commonly found around us, e.g in a retail enterprise sales data is continuously collected every day. A demand forecasting model is an…

Machine Learning · Statistics 2017-01-11 Chitta Ranjan , Samaneh Ebrahimi , Kamran Paynabar