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In typical high dimensional statistical inference problems, confidence intervals and hypothesis tests are performed for a low dimensional subset of model parameters under the assumption that the parameters of interest are unconstrained.…

Methodology · Statistics 2019-11-19 Ming Yu , Varun Gupta , Mladen Kolar

Shape-valued data are of interest in applied sciences, particularly in medical imaging. In this paper, inspired by a specific medical imaging example, we introduce a hypothesis testing method via the smooth Euler characteristic transform to…

Methodology · Statistics 2023-08-15 Jinyu Wang , Kun Meng , Fenghai Duan

Much research in machine learning involves finding appropriate inductive biases (e.g. convolutional neural networks, momentum-based optimizers, transformers) to promote generalization on tasks. However, quantification of the amount of…

Machine Learning · Computer Science 2024-06-25 Akhilan Boopathy , William Yue , Jaedong Hwang , Abhiram Iyer , Ila Fiete

It is known that statistical model selection as well as identification of dynamical equations from available data are both very challenging tasks. Physical systems behave according to their underlying dynamical equations which, in turn, can…

Mathematical Physics · Physics 2017-10-11 Sean Alan Ali , Carlo Cafaro

When analyzing real-world data it is common to work with event ensembles, which comprise sets of observations that collectively constrain the parameters of an underlying model of interest. Such models often have a hierarchical structure,…

Machine Learning · Statistics 2024-02-22 Lukas Heinrich , Siddharth Mishra-Sharma , Chris Pollard , Philipp Windischhofer

Foundation models, and in particular large language models, can generate highly informative responses, prompting growing interest in using these ''synthetic'' outputs as data in empirical research and decision-making. This paper introduces…

Artificial Intelligence · Computer Science 2025-12-02 Sanjog Misra

NLU models often exploit biases to achieve high dataset-specific performance without properly learning the intended task. Recently proposed debiasing methods are shown to be effective in mitigating this tendency. However, these methods rely…

Computation and Language · Computer Science 2020-10-14 Prasetya Ajie Utama , Nafise Sadat Moosavi , Iryna Gurevych

Neural language models (LMs) have been shown to capture complex linguistic patterns, yet their utility in understanding human language and more broadly, human cognition, remains debated. While existing work in this area often evaluates…

Computation and Language · Computer Science 2026-04-10 Kanishka Misra , Najoung Kim

We provide a general theory of the expectation-maximization (EM) algorithm for inferring high dimensional latent variable models. In particular, we make two contributions: (i) For parameter estimation, we propose a novel high dimensional EM…

Machine Learning · Statistics 2015-01-28 Zhaoran Wang , Quanquan Gu , Yang Ning , Han Liu

Biological systems commonly exhibit complex spatiotemporal patterns whose underlying generative mechanisms pose a significant analytical challenge. Traditional approaches to spatiodynamic inference rely on dimensionality reduction through…

Quantitative Methods · Quantitative Biology 2025-08-01 Jun Won Park , Kangyu Zhao , Sanket Rane

Feature selection has remained a daunting challenge in machine learning and artificial intelligence, where increasingly complex, high-dimensional datasets demand principled strategies for isolating the most informative predictors. Despite…

Machine Learning · Statistics 2025-12-02 Mousam Sinha , Tirtha Sarathi Ghosh , Ridam Pal

Many disciplines need quantitative models that synthesize experimental data across multiple instances of the same general system. For example, neuroscientists must combine data from the brains of many individual animals to understand the…

Machine Learning · Computer Science 2026-03-17 William E. Bishop , Luuk W. Hesselink , Bernhard Englitz , Misha B. Ahrens , James E. Fitzgerald

What happens to the optimal interpretation of noisy data when there exists more than one equally plausible interpretation of the data? In a Bayesian model-learning framework the answer depends on the prior expectations of the dynamics of…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Gurinder Singh Atwal , William Bialek

Predictive modeling plays key role in providing accurate prognosis and enables us to take a step closer to personalized treatment. We identified two potential sources of human induced biases that can lead to disparate conclusions. We…

Applications · Statistics 2017-02-08 Madhuchhanda Bhattacharjee

Complex phenomena in engineering and the sciences are often modeled with computationally intensive feed-forward simulations for which a tractable analytic likelihood does not exist. In these cases, it is sometimes necessary to estimate an…

Methodology · Statistics 2020-06-18 Niccolò Dalmasso , Ann B. Lee , Rafael Izbicki , Taylor Pospisil , Ilmun Kim , Chieh-An Lin

We develop a novel data-driven approach to the inverse problem of classical statistical mechanics: given experimental data on the collective motion of a classical many-body system, how does one characterise the free energy landscape of that…

Statistical Mechanics · Physics 2022-03-01 Peter Yatsyshin , Serafim Kalliadasis , Andrew B. Duncan

Inference after model selection has been an active research topic in the past few years, with numerous works offering different approaches to addressing the perils of the reuse of data. In particular, major progress has been made recently…

Methodology · Statistics 2020-06-02 Snigdha Panigrahi , Jonathan Taylor , Asaf Weinstein

We present a theoretical framework of probabilistic learning derived by Maximum Probability (MP) Theorem shown in the current paper. In this probabilistic framework, a model is defined as an event in the probability space, and a model or…

Machine Learning · Computer Science 2021-06-15 Amir Emad Marvasti , Ehsan Emad Marvasti , Ulas Bagci , Hassan Foroosh

Accurate diagnosis of psychiatric disorders plays a critical role in improving the quality of life for patients and potentially supports the development of new treatments. Many studies have been conducted on machine learning techniques that…

Machine Learning · Statistics 2019-04-15 Takashi Matsubara , Tetsuo Tashiro , Kuniaki Uehara

A fully Bayesian approach is proposed for ultrahigh-dimensional nonparametric additive models in which the number of additive components may be larger than the sample size, though ideally the true model is believed to include only a small…

Methodology · Statistics 2013-09-24 Zuofeng Shang , Ping Li
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