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The integrity of the reconstructed human epidermis generated in vitro could be assessed using histological analyses combined with immunohistochemical staining of keratinocyte differentiation markers. Computer-based analysis of scanned…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Dawid Zamojski , Agnieszka Gogler , Dorota Scieglinska , Michal Marczyk

The large volume and variety of imaging data from high-throughput screening (HTS) in the pharmaceutical industry present an excellent resource for training virtual staining models. However, the potential of models trained under one set of…

Machine Learning · Computer Science 2024-10-01 Samuel Tonks , Cuong Nguyen , Steve Hood , Ryan Musso , Ceridwen Hopely , Steve Titus , Minh Doan , Iain Styles , Alexander Krull

Conventional hematoxylin-eosin (H&E) staining is limited to revealing cell morphology and distribution, whereas immunohistochemical (IHC) staining provides precise and specific visualization of protein activation at the molecular level.…

Image and Video Processing · Electrical Eng. & Systems 2024-07-30 Fuqiang Chen , Ranran Zhang , Boyun Zheng , Yiwen Sun , Jiahui He , Wenjian Qin

To guide surgical and medical treatment X-ray images have been used by physicians in every modern healthcare organization and hospitals. Doctor's evaluation process and disease identification in the area of skeletal system can be performed…

Computer Vision and Pattern Recognition · Computer Science 2019-05-22 Rafsanjany Kushol , Md. Nishat Raihan , Md Sirajus Salekin , A. B. M. Ashikur Rahman

Histopathology can help clinicians make accurate diagnoses, determine disease prognosis, and plan appropriate treatment strategies. As deep learning techniques prove successful in the medical domain, the primary challenges become limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhe Li , Bernhard Kainz

Medical imaging segmentation is a highly active area of research, with deep learning-based methods achieving state-of-the-art results in several benchmarks. However, the lack of standardized tools for training, testing, and evaluating new…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Adrian Celaya , Evan Lim , Rachel Glenn , Brayden Mi , Alex Balsells , Dawid Schellingerhout , Tucker Netherton , Caroline Chung , Beatrice Riviere , David Fuentes

Validation of newly developed optical tissue sensing techniques for tumor detection during cancer surgery requires an accurate correlation with histological results. Additionally, such accurate correlation facilitates precise data labeling…

Image and Video Processing · Electrical Eng. & Systems 2023-11-23 Lianne Feenstra , Stefan D. van der Stel , Marcos Da Silva Guimaraes , Theo J. M Ruers , Behdad Dashtbozorg

Mucous glands lesions analysis and assessing of malignant potential of colon polyps are very important tasks of surgical pathology. However, differential diagnosis of colon polyps often seems impossible by classical methods and it is…

Computer Vision and Pattern Recognition · Computer Science 2018-06-21 A. Khvostikov , A. Krylov , O. Kharlova , N. Oleynikova , I. Mikhailov , P. Malkov

Variously stained histology slices are routinely used by pathologists to assess extracted tissue samples from various anatomical sites and determine the presence or extent of a disease. Evaluation of sequential slides is expected to enable…

Image and Video Processing · Electrical Eng. & Systems 2019-04-29 Ludovic Venet , Sarthak Pati , Paul Yushkevich , Spyridon Bakas

Due to recent advances in technology, digitized histopathology images are now widely available for both clinical and research purposes. Accordingly, research into computerized image analysis algorithms for digital histopathology images has…

Image and Video Processing · Electrical Eng. & Systems 2020-04-01 Alison K. Cheeseman , Hamid R. Tizhoosh , Edward R. Vrscay

Non-invasive brain imaging techniques allow understanding the behavior and macro changes in the brain to determine the progress of a disease. However, computational pathology provides a deeper understanding of brain disorders at cellular…

Image and Video Processing · Electrical Eng. & Systems 2023-01-18 Gabriel Jimenez , Daniel Racoceanu

A volumetric attention(VA) module for 3D medical image segmentation and detection is proposed. VA attention is inspired by recent advances in video processing, enables 2.5D networks to leverage context information along the z direction, and…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Xudong Wang , Shizhong Han , Yunqiang Chen , Dashan Gao , Nuno Vasconcelos

The human body is mysterious, consisting of innumerable fine and complex structures and a vast amount of information. The field of modern pathology has been systematized around the findings and observations obtained from light microscopy.…

Medical Physics · Physics 2021-11-29 Satoshi Kume

Background: X-ray dark-field radiography uses small-angle scattering to visualize the structural integrity of lung alveoli. To study the influence of dose reduction on clinical dark-field radiographs, one can simulate low-dose images by…

Medical Physics · Physics 2026-01-19 Henriette Bast , Rafael C. Schick , Thomas Koehler , Franz Pfeiffer

Histological visualizations are critical to clinical disease management and are fundamental to biological understanding. However, current approaches that rely on bright-field microscopy require extensive tissue preparation prior to imaging.…

Automatic segmentation of the prostate cancer from the multi-modal magnetic resonance images is of critical importance for the initial staging and prognosis of patients. However, how to use the multi-modal image features more efficiently is…

Image and Video Processing · Electrical Eng. & Systems 2020-11-10 Guokai Zhang , Xiaoang Shen , Ye Luo , Jihao Luo , Zeju Wang , Weigang Wang , Binghui Zhao , Jianwei Lu

Knowledge of x-ray attenuation is essential for developing and evaluating x-ray imaging technologies. For instance, techniques to better characterize cysts at mammography screening would be highly desirable to reduce recalls, but the…

Traditional staining normalization approaches, e.g. Macenko, typically rely on the choice of a single representative reference image, which may not adequately account for the diverse staining patterns of datasets collected in practical…

Image and Video Processing · Electrical Eng. & Systems 2024-06-11 Desislav Ivanov , Carlo Alberto Barbano , Marco Grangetto

Quantitative measurements of extended defects in crystalline materials are important in understanding material behaviour. X-ray line profile analysis provides a complement to direct counting in the electron microscope, but is an indirect…

Materials Science · Physics 2022-03-28 C P Race , T Ungar , G Ribarik

Accurate segmentation of vertebral metastasis in CT is clinically important yet difficult to scale, as voxel-level annotations are scarce and both lytic and blastic lesions often resemble benign degenerative changes. We introduce a 2D…

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