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Tip-Enhanced Raman Spectroscopy (TERS) combines Raman spectroscopy with scanning probe microscopy to overcome the spatial resolution limitation imposed by light diffraction, offering a primary optical technique for the comprehensive study…

This article reviews the new developments in Tip-enhanced Raman scattering (TERS). The fundamental mechanisms underlying the Raman enhancement are discussed, including the role of the plasmonic character of the metallic tips, the nature of…

Chemical Physics · Physics 2008-04-01 Catalin C. Neacsu , Samuel Berweger , Markus B. Raschke

Tip enhanced Raman scattering (TERS) amplifies the intensity of vibrational Raman scattering by employing the tip of a probe interacting, in ultra close proximity, with a surface. Although a general understanding of the TERS process is…

Tip-enhanced Raman scattering (TERS) has emerged as a powerful tool to obtain subnanometer spatial resolution fingerprints of atomic motion. Theoretical calculations that can simulate the Raman scattering process and provide an unambiguous…

Chemical Physics · Physics 2023-08-10 Y. Litman , F. P. Bonafé , A. Akkoush , H. Appel , M. Rossi

Tip-Enhanced Raman Spectroscopy (TERS) can be used to make nanoscale spatial measurements of 2D materials, such as graphene and transition metal dichalcogenides (TMDs). The TERS theory introduced in [Phys. Rev. X 4, 031054 (2014)], however,…

Optics · Physics 2026-05-12 Raul Corrêa , Luiz G. Cançado , Ado Jorio

Tip-enhanced Raman spectroscopy (TERS) has reached nanometer spatial resolution for measurements performed at ambient conditions and sub-nanometer resolution at ultra high vacuum. Super-resolution (beyond the tip apex diameter) TERS has…

Tip-Enhanced Raman Spectroscopy (TERS) provides nanoscale chemical fingerprints alongside high-resolution topographic mapping of molecules, offering a powerful tool for materials discovery. However, TERS image datasets are challenging to…

Materials Science · Physics 2026-02-24 Harshit Sethi , Markus Junttila , Orlando J Silveira , Adam S Foster

Single molecule detection, sequencing and conformational mapping of aptamers are important for improving medical and biosensing technologies and for better understanding of biological processes at the molecular level. We obtain vibrational…

Biomolecules · Quantitative Biology 2016-12-05 Siyu He , Hongyuan Li , Zhe He , Dmitri V. Voronine

Single-molecule tip-enhanced Raman spectroscopy (TERS) under ultra-high vacuum (UHV) and cryogenic conditions enables exploration of the relations between the adsorption geometry, electronic state, and vibrational fingerprints of individual…

Tip-enhanced Raman spectroscopy (TERS) is a valuable method for surface analysis with nanometer to angstrom-scale resolution, however, the accurate simulation of particular TERS signals remains a computational challenge. We present a unique…

Tip-enhanced Raman spectroscopy (TERS) combines inelastic light scattering well below the diffraction limit down to the nanometer range and scanning probe microscopy and, possibly, spectroscopy. In this way, topographic and spectroscopic as…

Superconductivity · Physics 2023-06-06 Leander Peis , Ge He , Daniel Jost , Gabriele Rager , Rudi Hackl

Tip-enhanced Raman spectroscopy (TERS) enables nanoscale chemical mapping of biological structures, providing high-resolution, high-signal-to-noise ratio imaging into molecular distribution and interactions beyond the capabilities of…

Tip-enhanced Raman spectroscopy (TERS) with sub-nanometer spatial resolution has been recently demonstrated experimentally. However, the physical mechanism underlying is still under discussion. Here, we theoretically investigate the…

Mesoscale and Nanoscale Physics · Physics 2015-03-10 Lingyan Meng , Zhilin Yang , Jianing Chen , Mengtao Sun

Photo-Induced Enhanced Raman Spectroscopy (PIERS) is a new surface enhanced Raman spectroscopy (SERS) modality with an order-of-magnitude Raman signal enhancement of adsorbed analytes over that of typical SERS substrates. Despite the…

Materials Science · Physics 2021-06-01 Junzhi Ye , Rakesh Arul , Michel K. Nieuwoudt , Junzhe Dong , Wei Gao , M. Cather Simpson

Determining the chemical structure for a single molecule on surface from spectroscopic data represents a challenging high-dimensional inverse problem. Tip-enhanced Raman spectroscopy (TERS) enables chemically specific imaging of single…

Chemical Physics · Physics 2026-03-24 Jie Cui , Yao Zhang , Yang Zhang , Yi Luo , Zhen-Chao Dong

Using p-aminothiophenol (PATP) molecules on a gold substrate as prototypical examples and high vacuum tip-enhanced Raman spectroscopy (HV-TERS), we show that the vibrational spectra of those molecules are distinctly different from those in…

Atomic and Molecular Clusters · Physics 2015-03-10 Mengtao Sun , Yurui Fang , Zhenyu Zhang , Hongxing Xu

In this article, tip-enhanced Raman spectroscopy (TERS) is investigated as a precise method for analysis of biological samples. Using Finite Difference Time Domain (FDTD) simulation, it has been tried to design the required structures for…

Atomic Physics · Physics 2024-02-21 Fatemeh Sadat Khademi , Maryam Bahreini

Surface Enhanced Raman Spectroscopy (SERS) is a well-established technique for enhancing Raman signals. Recently photonic integrated circuits have been used, as an alternative to microscopy based excitation and collection, to probe SERS…

We report a detailed study of the strong near-field Raman scattering enhancement which takes place in tip-enhanced Raman scattering (TERS) in indium nitride. In addition to the well-known first-order optical phonons of indium nitride,…

The vibrational landscape of adsorbed molecules is central to understanding surface interactions at the atomic scale, influencing phenomena from catalysis to molecular electronics. Recent advances in atomic-scale tip-enhanced Raman…

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